Late‐onset cerebellar abiotrophy in a Labrador Retriever

Bertalan, A; En, Glass; Kent, Marc; Lahunta, Alexander de; Bradley, Charles W.

doi:10.1111/avj.12211

Cited by 12 publications

(10 citation statements)

References 18 publications

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“…For the identification of inflammatory lesions the characteristics of the MRI lesion, its behaviour concerning contrast enhancement, the results of CSF analysis and blood results were considered (Tipold 1995, Kitagawa et al 2004, Platt & Olby 2004, Talarico & Schatzberg 2010, Coates & Jeffery 2014, Cardy & Cornelis 2018.Presumed infarcts and bleeding caused by traumatic brain injury or presumed microbleeds were differentiated using MRI characteristics, case history and other diagnostic tests (Platt & Olby 2004, Garosi et al 2006, Garosi 2010, Thomsen et al 2016, Kerwin et al 2017. Lesions in the brain with other aetiologies such as congenital malformation, abiotrophy or hydrocephalus were also differentiated as precisely as possible (De Lahunta & Glass 2009, Bernardino et al 2015, Bertalan et al 2014, Kwiatkowska et al 2013, Laubner et al 2015.…”

Section: Diagnostic Findingsmentioning

confidence: 99%

Vestibular disease in dogs: association between neurological examination, MRI lesion localisation and outcome

Bongartz¹,

Neßler²,

Maiolini³

et al. 2019

J of Small Animal Practice

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Objectives To determine whether the neurological examination correctly distinguishes between central and peripheral vestibular lesions in dogs. Materials and Methods Retrospective study on dogs with vestibular disease presenting to two referral clinics in Germany. Results Ninety‐three dogs were included; neurological examination suggested central vestibular disease in 62 and a peripheral lesion in 31. MRI diagnosis was central vestibular disease in 68 dogs and peripheral in 25. Of the 62 dogs with a lesion localisation diagnosed as central vestibular by neurological exam, 61 were correctly identified (98.4%). Twenty‐four of the 31 dogs diagnosed with a peripheral lesion by neurological exam had a consistent lesion on MRI (77.4%). Clinical Significance The neurological examination is efficient at identifying lesions in the central vestibular system but less so for peripheral lesions. Therefore it is prudent to recommend imaging in dogs that show signs of peripheral vestibular syndrome but do not rapidly respond to treatment.

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Section: Diagnostic Findingsmentioning

confidence: 99%

Vestibular disease in dogs: association between neurological examination, MRI lesion localisation and outcome

Bongartz¹,

Neßler²,

Maiolini³

et al. 2019

J of Small Animal Practice

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“…However, there are many other canine breeds showing clinical as well as histopathological evidence of NCL, but the genetic background of the disease has not been elucidated so far in these breeds. Examples comprise Australian Cattle Dog, Cocker Spaniel, Dalmatian, Labrador Retriever, Miniature Schnauzer, and Saluki (2,6,12,18,29,32).…”

Section: Discussionmentioning

confidence: 99%

Neuronale Zeroidlipofuszinose bei einem adulten American Staffordshire Terrier

Nolte¹,

Bello²,

Drögemüller³

et al. 2016

Tierarztl Prax Ausg K

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A female, 5-year-old American Staffordshire Terrier with severe progressive neurological deficits, particularly in terms of ataxia and keeping balance, was examined pathomorphologically and a genetic analysis was performed. In neurons of various localizations of the central nervous system an accumulation of a finely granular pale eosinophilic or light brown material was found. In addition, the cerebellum revealed marked degeneration and loss of Purkinje and inner granule cells. The accumulated PAS-positive, argyrophilic, autofluorescent material showed ultrastructurally a lamellar appearance suggestive of lipofuscin. Genetic analysis revealed the presence of a sequence variant in the ARSG gene encoding the lysosomal enzyme arylsulfatase G. This case report describes an adult-onset of a neuronal ceroid lipofuscinosis that shows similarities with a human disorder termed Kufs disease.

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“…A case report describes late‐onset cerebellar abiotrophy (CA) in a mature Labrador Retriever . Previous cases of early and intermediate CA have been described in various dog breeds.…”

Section: Small Animalsmentioning

confidence: 96%