Late-onset Cogan's syndrome associated with large-vessel vasculitis

Cabezas-Rodríguez, Iván; Brandy-Garcia, Anahy; Rodríguez-Balsera, C.; Rozas-Reyes, P.; Fernández-Llana, Belen; Arboleya-Rodríguez, Luis

doi:10.1016/j.reumae.2017.05.011

Cited by 2 publications

(2 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The average age at disease onset is 29 years, but although less common, there have been several descriptions of late-onset disease, as in the case presented [3] . The onset of disease is preceded by respiratory tract infection in approximately 30% of cases.…”

Section: Discussionmentioning

confidence: 93%

Aortitis Secondary to Cogan’s Syndrome: A Rare Cause of Fever of Unknown Origin

Rosado

Queirós

Conceição

et al. 2022

European Journal of Case Reports in Internal Medicine

View full text Add to dashboard Cite

Fever of unknown origin remains a diagnostic challenge. Aortitis, defined as inflammation of the aorta, has multiple infectious and non-infectious causes.<br/> We report the case of an elderly woman with vertigo and bilateral hearing loss, presenting with fever of unknown origin. Blood tests were remarkable for leucocytosis with neutrophilia, elevation of C-reactive protein and the erythrocyte sedimentation rate, and positive antinuclear antibodies and rheumatoid factor, and an unremarkable search for multiple infectious causes of fever. During admission the patient developed a bilateral red eye. Abdominal and chest computed tomography was performed and demonstrated signs of aortitis. Due to the coexistence of aortitis, ocular inflammation, vertigo and bilateral hearing loss in a patient with persistent fever and elevation of inflammatory parameters, a presumptive diagnosis of Cogan’s syndrome was made, with improvement after initiation of steroid therapy.

show abstract

Section: Discussionmentioning

confidence: 93%

Aortitis Secondary to Cogan’s Syndrome: A Rare Cause of Fever of Unknown Origin

Rosado

Queirós

Conceição

et al. 2022

European Journal of Case Reports in Internal Medicine

View full text Add to dashboard Cite

show abstract

“…At the onset of audio-vestibular dysfunction, rapid initiation of high dose corticosteroids (1–1.5 mg/kg of prednisone daily) is recommended, expecting a beneficial response to be noticed within 2–3 weeks. 7 , 56 Cabezas-Rodriguez et al 57 reported significant hearing improvements after treatment with intravenous methylprednisolone. This single-drug regimen, however, should last no longer than 2–3 weeks due to either the development of significant glucocorticoid-induced toxicity or the inability to taper the dosage maintaining the control of the disease.…”

Section: Multidisciplinary Approach To Treatment Of Csmentioning

confidence: 99%

Optimal management of Cogan’s syndrome: a multidisciplinary approach

D’Aguanno¹,

Ralli²,

Vincentiis³

et al. 2017

JMDH

View full text Add to dashboard Cite

Cogan’s syndrome (CS) is a rare disorder characterized by nonsyphilitic interstitial keratitis (IK) and audio-vestibular symptoms. CS affects mainly young Caucasian adults, mostly during their first three decades of age, and may develop into typical and atypical variants. Typical CS manifests primarily with IK and hearing loss, whereas atypical CS usually presents with inflammatory ocular manifestations in association with audio-vestibular symptoms but mostly different Ménière-like symptoms and, more frequently, with systemic inflammation (70%), of which vasculitis is the pathogenic mechanism. CS is considered as an autoimmune- or immune-mediated disease supported mainly by the beneficial response to corticosteroids. Using well-developed assays, antibodies to inner ear antigens, anti-Hsp70, and antineutrophil cytoplasmic antibodies were found to be associated with CS. Corticosteroids represent the first line of treatment, and multiple immunosuppressive drugs have been tried with variable degrees of success. Tumor necrosis factor-alpha blockers and other biological agents are a recent novel therapeutic option in CS. Cochlear implantation is a valuable rescue surgical strategy in cases with severe sensorineural hearing loss unresponsive to intensive and/or innovative immunosuppressive regimens.

show abstract

Late-onset Cogan's syndrome associated with large-vessel vasculitis

Cited by 2 publications

References 13 publications

Aortitis Secondary to Cogan’s Syndrome: A Rare Cause of Fever of Unknown Origin

Aortitis Secondary to Cogan’s Syndrome: A Rare Cause of Fever of Unknown Origin

Optimal management of Cogan’s syndrome: a multidisciplinary approach

Contact Info

Product

Resources

About

Late-onset Cogan's syndrome associated with large-vessel vasculitis

Cited by 2 publications

References 13 publications

Aortitis Secondary to Cogan’s Syndrome: A Rare Cause of Fever of Unknown Origin

Aortitis Secondary to Cogan’s Syndrome: A Rare Cause of Fever of Unknown Origin

Optimal management of Cogan&rsquo;s syndrome: a multidisciplinary approach

Contact Info

Product

Resources

About

Optimal management of Cogan’s syndrome: a multidisciplinary approach