Late onset Cogan's syndrome

Fidler, H. K.; Jones, Nick

doi:10.1017/s0022215100156749

Cited by 8 publications

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“…Zur Therapie erwachsener Patienten wurden Prednisolon-Gaben von 40 mg täglich bis hin zu initial 1000 mg/Tag intravenös für 3 Tage und anschließend orale Gaben von 100 mg/Tag in absteigender Dosierung bis 10 mg/Tag eingesetzt [1,5,7,13,14]. Eine Therapie mit Immunsuppressiva, wie Cyclophosphamid,Azathioprin, Methotrexat und Ciclosporin, kommt bei Verstärkung der Symptomatik unter Steroidreduktion, bei der systemischen Form des Cogan-I-Syndroms und bei starken Steroidnebenwirkungen in Frage [1,13].…”

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Das Cogan-I-Syndrom

Massinger¹,

Keilmann²

2003

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We report on two patients affected by Cogan's syndrome since infancy.Cogan's syndrome is described as the association of abrupt or intermittent worsening of vestibulo-auditory function and non-syphilic interstitial keratitis or, in patients with "atypical" Cogan's syndrome, various severe, inflammatory eye diseases. The first patient was affected with different inflammatory eye diseases from her fifth year and became blind in one eye when she was 7 years old. At that time, a deterioration of her hearing ability was also diagnosed. The hearing loss progressed to a severe hearing disorder. The second patient suffered from different inflammatory eye diseases from his second year. When he was 3 years old,he was diagnosed with a severe hearing disorder that progressed.Cogan's syndrome was diagnosed when he was 13 years old. The recognition of Cogan's syndrome is particularly complex in young patients. The difficulty of the diagnosis requires a search for ophthalmic diseases in young children with acute and progressive vestibulo-auditory symptoms.

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