Late-Onset Donor-to-Host Transmission of Candida glabrata Following Corneal Transplantation

Abstract

This case provides support for the practice of obtaining routine fungal cultures of donor rims at the time of corneal transplantation and for the implementation of prophylactic antifungal therapy in culture-positive cases.

Outcome of primary adult optical penetrating keratoplasty with imported donor corneas

“…There were no cases of early onset bacterial keratitis or endophthalmitis associated with contaminated donor rims. Although fungal contamination of the donor rim is often associated with early onset and late-onset fungal keratitis and/or endophthalmitis [11,12,36,37], this did not occur in association with any of the fungal-contaminated donor rims in the present study.…”

Candida glabrata endophthalmitis following penetrating keratoplasty

“…[1][2][3][4][5][6][15][16][17][18][19] A disproportionately large number of these cases (9) were endophthalmitis that occurred following PKP (Table 1). [1][2][3][4][5][6][7][8][9] After the first case of post-keratoplasty C glabrata endophthalmitis was reported in 1978, only 2 were reported until 1998. 2,9 Since then, 7 cases (including ours) have been reported following PKP, 3,5-8 5 in the past 3 years.…”

Fungal keratitis following amniotic membrane transplantation

“…To our knowledge, this is the first reported case of fungal keratitis following AMT. However, late-onset donor-to-host transmission of fungal infection after penetrating keratoplasty has been reported [6].…”