Late-Onset Eccrine Angiomatous Hamartoma: Clinical, Histological and Imaging Findings

Laeng, R. Hubert; Heilbrunner, J.; Itin, Peter

doi:10.1159/000051709

Cited by 28 publications

(36 citation statements)

References 10 publications

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“…MRI revealed contrast-enhanced subcutaneous lesions with diffuse signal intensities in T1- and T2-weighted sequences. These findings show similarities with a previous study by Laeng et al [23]. …”

Section: Discussionsupporting

confidence: 93%

“…The mechanisms of multiple EAH spreading to several parts of the body may be due to mosaicism of gene mutation occurring in the early developmental stage. It has also been described in association with radiation therapy and repeated trauma [23,24]. Nevertheless, in our patients we found no related history of trauma or radiation.…”

Section: Discussionsupporting

confidence: 48%

“…Imaging procedures such as MRI are helpful in evaluating the extend of the lesions prior to surgical excision of a very large area [11,23]. Ultrasound was performed in one patient (case 26), who had severe pain as well as walking and moving difficulties, and showed diffuse lesions with increased blood flow.…”

Section: Discussionmentioning

confidence: 99%

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Eccrine Angiomatous Hamartoma: A Clinicopathological Study of 26 Cases

Sanusi

Li²,

Sun³

et al. 2015

Dermatology

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Background: Eccrine angiomatous hamartoma (EAH) is a rare benign cutaneous tumor characterized by the proliferation of eccrine glands and capillaries. Objective: The aim of this study was to summarize the clinicopathological characteristics of EAH. Methods: A retrospective chart review was performed on all patients diagnosed with EAH from 1977 to 2012 in the Union Hospital, Wuhan, P.R. China, and the clinicopathological features were compared with the cases reported in the literature. Results: A total of 26 patients with EAH were identified. The male:female ratio was 1.2:1. EAH most commonly presents as a solitary (80.8%) plaque (50.0%) on the lower extremities (61.5%). Most patients presented with hyperhidrosis localizing to the lesion. Although most patients did not have major pain or anatomic deformity, one patient had severe pain as well as difficulty walking and moving, necessitating leg amputation. The histopathological findings showed typical features of EAH. Conclusion: EAH is a rare but characteristically benign skin hamartomatous condition. In rare occasions it can be associated with severe structural and functional impairment.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 48%

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Eccrine Angiomatous Hamartoma: A Clinicopathological Study of 26 Cases

Sanusi

Li²,

Sun³

et al. 2015

Dermatology

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“…2,12,13 We disclosed no anamnestic, clinical or paraclinical clues to the sudden enlargement and increased hyperhidrosis in our patient.…”

Section: Discussionmentioning

confidence: 63%

Large eccrine angiomatous hamartoma: a novel clinical presentation of disease

Nygaard

Dalager

Spaun

et al. 2015

J Dermatol Case Rep

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Background: Eccrine angiomatous hamartoma is a rare benign cutaneous malformation with a diverse clinical appearance, therefore likely to be misdiagnosed and underreported.Main observations: A 44-year-old man presented with a congenital erythematous hyperhidrotic plaque on the left upper back measuring 18 x 25 cm. No pain or tenderness nor hypertrichosis were observed. Histopathology was consistent with the mucinous variant of eccrine angiomatous hamartoma. Intralesional injection of botulinum toxin type A greatly reduced localized sweating, improving patient quality of life. Conclusions:This article describes a novel clinical presentation of eccrine angiomatous hamartoma: large, erythematous, and slightly indurated plaque localized on the upper back. It emphasizes the role of histopathology in the diagnostic process and botulinum toxin as a viable treatment option. (J Dermatol Case Rep. 2015; 9(3): 58-61)

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“…17,18 However, unlike in normal eccrine glands, immunostaining for EMA showed that the tall epithelial lining of secretory coils display extended glycocalyx reactive for EMA and numerous narrow intercellular clefts, which may reflect the morphological correlate of hyperhidrosis. 19 The origin of MEN is not clear. Espana et al 5 proposed that the distribution of skin lesions following the lines of Blaschko may be a clue suggesting the result of the migration path of clones of genetically identical cells during fetal development.…”

Section: Discussionmentioning

confidence: 99%