Late onset leptomeningeal and whole spine metastasis from supratentorial Glioblastoma multiforme: An uncommon manifestation of a common tumor

Abstract

Glioblastoma multiforme (GBM) is one of the most common and aggressive primary brain tumors, composing 12-20% of all the intracranial tumors in adults with a highly malignant course and average life expectancy of approximately 12-14 months following initial diagnosis. Leptomeningeal or intramedullary metastasis from primary GBM is a rare phenomenon with a poor prognosis. We present a rare case of GBM with late onset intramedullary, extramedullary, as well as leptomeningeal spinal metastasis.

Giant-cell glioblastoma in a child: A rare case report and literature review

“…Besides, a study of 18 pediatric patients by Karremann et al showed no significant difference in median age, male preference, median clinical history, and prognosis between GCG and GBM [7]. Spinal metastasis from primary GBM is extremely rare and occurs relatively late [18,19]. Treatment modalities include surgery for decompression, RT in total dose of 25-40 Gy and intrathecal CH.…”

“…Therefore, RT is used most commonly. There is no obvious survival advantage of one therapy over the other and the prognostic is poor [18,19].…”