Late radiation effects on hearing, vestibular function, and taste in brain tumor patients

Johannesen, Tom Børge; Rasmussen, Kjell; Winther, Finn Ø.; Halvorsen, Ulf; Lote, Knut

doi:10.1016/s0360-3016(01)02810-3

Cited by 89 publications

(60 citation statements)

References 30 publications

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“…However, one study reported accurate identification of patients with a hearing level better than 25 dB for frequencies between 1 and 4 kHz. Also, a TEOAE correctly indentified all cases with a hearing threshold worse than 25 dB HL for all frequencies between 1 and 4 kHz (Johannesen et al 2002).…”

Section: Additional Function Testsmentioning

confidence: 85%

“…Incidence of these dysfunctions increased above doses of 55 Gy to the inner ear (Bhandare et al 2007). Data on the relationship between incidence of vestibular dysfunction, including imbalance and vertigo, as well as dose response remain sparse and inconclusive (Young et al 2004;Johannesen et al 2002). Though cases of vestibular dysfunction after fractionated RT have been reported, the number of such cases remains too limited to draw any conclusions regarding a dose-response relationship.…”

Section: Vestibular Dysfunctionmentioning

confidence: 99%

See 1 more Smart Citation

Radiation-Induced Ototoxicity

Bhandare

Eisbruch

Antonelli

et al. 2013

ALERT • Adverse Late Effects of Cancer Treatment

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Section: Additional Function Testsmentioning

confidence: 85%

Section: Vestibular Dysfunctionmentioning

confidence: 99%

Radiation-Induced Ototoxicity

Bhandare

Eisbruch

Antonelli

et al. 2013

ALERT • Adverse Late Effects of Cancer Treatment

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“…Radiotherapy also may cause a variety of side effects, such as oral problems, redness or skin irritation, swelling, salivary gland damages, etc. Hearing problems are also common side effects of radiotherapy in these patients (6)(7)(8)(9)(10). Anteunis et al reported that more than 50% of patients treated by the radiation suffered from some hearing problems (11).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Radiation Therapy on Hearing Loss in Patients with Head and Neck Cancer

et al. 2018

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Background: Radiotherapy is one of the important components of head and neck cancer (HNC) treatment. This treatment method may cause a variety of side effects like oral problems, swelling, and hearing loss. Objectives: In this study, the effect of radiotherapy on hearing loss in patients with HNC was investigated. Methods: In this prospective cohort research, patients with head and neck cancer referring to the Shohadaye Tajrish Hospital during 2014 to 2015 were investigated. All of these patients were candidate for radiotherapy as the main treatment. The radiotherapy of patients was done by 3D-computer based treatment planning system, using their CT scan. In order to oncologic assessment, preand post-radiotherapy audiologic evaluations were done. The common toxicity criteria for the adverse events (CTCAE V4.02) of the National Cancer Institute (NCI) were used for ototoxicity. A bivariate latent variable model was used to assess the effect of received dose on the severity of hearing loss. Results: In this study, 66 patients with HNC were investigated. Among them, 46 patients (70%) were male. The mean (SD) age of patients was 45.33 (15.11). The incidence rate of hearing loss in these patients was about 18%. The result of statistical modeling showed a positive relationship between severity of HL and received dose of radiation (P < 0.001). Conclusions:In general, the findings of this study showed a direct relationship between radiation dose received by the ears and severity of hearing loss in patients with HNC. In this context, paying more attention to dose-prescription limits and standards for assessing radiation therapy associated ototoxicity are strictly recommended.

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“…Other authors have reported a bilateral sensorineural deficiency in the high frequencies as a consequence to the radiation. [8][9][10] Our study aimed at assessing the auditory system function in patients submitted to radiotherapy in the head and neck region because of the concern with its ototoxic effects.…”

Section: Introductionmentioning

confidence: 99%

Achados audiológicos em pacientes tratados com radioterapia para tumores de cabeça e pescoço

Dell'Aringa¹,

Isaac²,

Arruda³

et al. 2010

Braz. j. otorhinolaryngol. (Impr.)

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Radiotherapy has been widely used given its increase in the successful outcomes and cure of some cancers. Aim To evaluate the functionality of the auditory system in patients who underwent radiotherapy treatment for head and neck tumors. Materials and Methods From May 2007 to May 2008, otorhinolaryngological and audiological evaluation (Pure Tone Audiometry (air and bone conduction), Speech Audiometry, Tympanometry, Acoustic Reflex testing and Distortion Product Otoacoustic Emissions) were performed in 19 patients diagnosed with head and neck neoplasia and treated with radiotherapy. Prospective case series study. Results 10.5% left ears and 26.3% right ears had bilateral hearing loss soon after radiotherapy according to ASHA criteria. Conclusions Radiotherapy treatment for head and neck cancer has ototoxic effects. Early programs of auditory rehabilitation should be offered to these patients.

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Late radiation effects on hearing, vestibular function, and taste in brain tumor patients

Cited by 89 publications

References 30 publications

Radiation-Induced Ototoxicity

Radiation-Induced Ototoxicity

The Effect of Radiation Therapy on Hearing Loss in Patients with Head and Neck Cancer

Achados audiológicos em pacientes tratados com radioterapia para tumores de cabeça e pescoço

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