Late Stages of Pulmonary Hyaline Membranes of the Newborn

Hyaline Membrane Disease: I: Cellular Changes

“…Many of the cells consisted of the large thick squames previously described, and there were very few capillaries in apposition to them. In many respects the epithelial changes at this late stage resembled those described by Robertson, Tunell, and Rudhe (1964) and Rowland and Newman (1969); as these authors suggested, the repair processes are probably modified by the high concentrations of oxygen used in the treatment of HMD. In this connexion, our observations on epithelial necrosis and subsequent repair in HMD resemble the changes described by Kaplan et al (1969) and Kapanci et al (1969) in the lungs of monkeys exposed to 100% 02, though there was no HM formation.…”

Intermittent positive pressure respiration as a treatment in severe respiratory distress syndrome.

“…4), indicating a reduction in the large A-a gradient characteristic of the acute stage of the disease (Nelson, Prod'hom, Cherry, Lipsitz, and Smith, 1963;Strang and , 1961;Warley and Gairdner, 1962). The effects of continued exposure to the relatively high oxygen percentages delivered by the ventilator (even with the '40% air mix') are unknown but may be harmful (Robertson, Tunell, and Rudhe, 1964). Improvements in ventilator design permitting graded reduction in oxygen concentrations are desirable.…”

On the pulmonary toxicity of oxygen: III. The induction of oxygen dependency by oxygen use

“…The evidence of their connection with the then described lesion complex of bronchopulmonary dysplasia is fairly extensive and convincing Northway, et al, 1967;Balentine, 1982). Nevertheless, various reports are not in agreement on the relative significance or the separability of these factors (Balentine, 1982;Northway, et al, 1967;Robertson, et al, 1964). This is of particular interest in light of the increasing importance of genetic mutations, more especially in the healing phases (Shanklin, et al, 2008).…”