Latency of vestibular responses of pursuit neurons in the caudal frontal eye fields to whole body rotation

Akao, Teppei; Saitô, Hiroshi; Fukushima, Junko; Kurkin, Semen A.; Fukushima, Kunihiro

doi:10.1007/s00221-006-0682-5

Cited by 18 publications

(48 citation statements)

References 46 publications

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“…The majority of FEF pursuit neurons carry not only visual signals about target motion but also vestibular signals about whole-body rotation that activates primarily semi-circular canals (Fukushima et al 2000(Fukushima et al , 2002aAkao et al 2005Akao et al , 2006. Moreover, the majority of them also responded to otolith inputs induced by horizontal whole-body translation .…”

Section: Introductionmentioning

confidence: 99%

Activity of pursuit neurons in the caudal part of the frontal eye fields during static roll-tilt

et al. 2007

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The smooth-pursuit system and vestibular system interact to keep the retinal target image on the fovea during head and/or whole body movements. The caudal part of the frontal eye fields (FEF) in the fundus of arcuate sulcus contains pursuit neurons and the majority of them respond to vestibular stimulation induced by whole-body rotation, that activates primarily semi-circular canals, and by whole-body translation, that activates otoliths. To examine whether coordinate frames representing FEF pursuit signals are orbital or earth-vertical, we compared preferred directions during upright and static, whole-body roll-tilt in head-and trunk-restrained monkeys. Preferred directions (re monkeys' head/trunk axis) of virtually all pursuit neurons tested (n=21) were similar during upright and static whole-body roll-tilt. The slight shift of preferred directions of the majority of neurons could be accounted for by ocular counter-rolling. The mean (±SD) differences in preferred directions between upright and 40° right ear down and between upright and 40° left ear down were 6° (± 6°) and 5° (± 5°), respectively. Visual motion preferred directions were also similar in 5 pursuit neurons tested. To examine whether FEF pursuit neurons could signal static whole-body roll-tilt, we compared mean discharge rates of 29 neurons during fixation of a stationary spot while upright and during static, whole-body roll-tilt. Virtually all neurons tested (28/29) did not exhibit a significant difference in mean discharge rates between the two conditions. These results suggest that FEF pursuit neurons do not signal static roll-tilt and that they code pursuit signals in head/trunk-centered coordinates.

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Section: Introductionmentioning

confidence: 99%

Activity of pursuit neurons in the caudal part of the frontal eye fields during static roll-tilt

et al. 2007

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“…FPA neurons show a range of activity patterns during pursuit in the preferred direction, ranging from phasic bursts of activity at pursuit onset to slowly developing, tonic activity that is sustained throughout the pursuit response (Ono and Mustari 2009). Many FPA neurons also receive vestibular inputs (Akao et al 2007Fukushima et al 2000) that may be important for coordinating smooth eye movements during whole body movements. FPA neurons with different activity patterns tend to project to different precerebellar nuclei in the pons (Ono and Mustari 2009), implying that the descending output form the FPA controls multiple components of the pursuit response.…”

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confidence: 99%

Inactivation and stimulation of the frontal pursuit area change pursuit metrics without affecting pursuit target selection

Mahaffy

Krauzlis

2011

Journal of Neurophysiology

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“…Previously, we have shown that pursuit signals and vestibular signals add linearly in pursuit neurons in the caudal part of the frontal eye fields during cancellation of the VOR induced by whole body step-rotation (Akao et al 2007). The study by Mustari et al (2003) also documents asymmetry of horizontal smooth-pursuit and asymmetry in cancellation of the VOR following unilateral muscimol inactivation of the dorsolateral pontine nucleus.…”

Section: Discussionmentioning

confidence: 94%

“…4a, b, open arrows; also Takeichi et al 2003). Previous studies examined horizontal smooth-pursuit and VOR cancellation using the identical stimulus trajectory (Akao et al 2007); the latency and the time course of eye velocity of the residual VOR during VOR cancellation was also predicted by linear addition of eye velocity during smooth-pursuit and VOR x1.…”

Section: Discussionmentioning

confidence: 98%

“…To examine the time course of VOR cancellation in the two (S, Y) monkeys, whole body step-rotation (20°/s for 1 s, peak acceleration ~600°/s 2 ) was also applied either vertically or horizontally with random inter-trial intervals of 1-3.5 s as reported previously (e.g., Akao et al 2007). Target position was controlled using the chair position signal obtained from a potentiometer attached to the axis of the turntable.…”

Section: Training and Recording Procedures And Behavioral Paradigmsmentioning

confidence: 99%

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Directional asymmetry in vertical smooth-pursuit and cancellation of the vertical vestibulo-ocular reflex in juvenile monkeys

et al. 2007

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Young primates exhibit asymmetric eye movements during vertical smooth-pursuit across a textured background such that upward pursuit has low velocity and requires many catch-up saccades. The asymmetric eye movements cannot be explained by the un-suppressed optokinetic reflex resulting from background visual motion across the retina during pursuit, suggesting that the asymmetry reflects most probably, a low gain in upward eye commands (Kasahara et al. 2006). In this study we examined 1) whether there are intrinsic differences in the upward and downward pursuit capabilities and 2) how the difficulty in upward pursuit is correlated with the ability of vertical VOR cancellation. Three juvenile macaques that had initially been trained only for horizontal (but not vertical) pursuit were trained for sinusoidal pursuit in the absence of a textured background. In 2 of the 3 macaques, there was a clear asymmetry between upward and downward

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Latency of vestibular responses of pursuit neurons in the caudal frontal eye fields to whole body rotation

Cited by 18 publications

References 46 publications

Activity of pursuit neurons in the caudal part of the frontal eye fields during static roll-tilt

Activity of pursuit neurons in the caudal part of the frontal eye fields during static roll-tilt

Inactivation and stimulation of the frontal pursuit area change pursuit metrics without affecting pursuit target selection

Directional asymmetry in vertical smooth-pursuit and cancellation of the vertical vestibulo-ocular reflex in juvenile monkeys

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