Latent Stereopsis for Motion in Depth in Strabismic Amblyopia

Hess, Robert F.; Mansouri, Behzad; Thompson, Benjamin; Gheorghiu, Elena

doi:10.1167/iovs.09-3551

Cited by 32 publications

(31 citation statements)

References 30 publications

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“…In addition, interocular suppression could be alleviated by wearing an ND filter over the nonamblyopic eye in amblyopic observers. 6,8,[40][41][42]46,47 By establishing and alleviating interocular suppression using mean luminance modulation, we verified that the dichoptic suppression mapping technique could, indeed, provide topographically specific evaluation of interocular suppression in the central visual field of anisometropic amblyopes. The luminance stimuli in our study were used as first-order targets even though the amblyopic visual system also is sensitive to second-order image characteristics, such as contrast modulations.…”

Section: Discussionsupporting

confidence: 52%

Spatial and Global Sensory Suppression Mapping Encompassing the Central 10° Field in Anisometropic Amblyopia

Chen

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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Citation: Li J, Li J, Chen Z, et al. Spatial and global sensory suppression mapping encompassing the central 108 field in anisometropic amblyopia. Invest Ophthalmol Vis Sci. 2017;58:481-491. DOI:10.1167/ iovs.16-20298 PURPOSE. We investigate the efficacy of a novel dichoptic mapping paradigm in evaluating visual function of anisometropic amblyopes. METHODS.Using standard clinical measures of visual function (visual acuity, stereo acuity, Bagolini lenses, and neutral density filters) and a novel quantitative mapping technique, 26 patients with anisometropic amblyopia (mean age ¼ 19.15 6 4.42 years) were assessed. Two additional psychophysical interocular suppression measurements were tested with dichoptic global motion coherence and binocular phase combination tasks. Luminance reduction was achieved by placing neutral density filters in front of the normal eye.RESULTS. Our study revealed that suppression changes across the central 108 visual field by mean luminance modulation in amblyopes as well as normal controls. Using simulation and an elimination of interocular suppression, we identified a novel method to effectively reflect the distribution of suppression in anisometropic amblyopia. Additionally, the new quantitative mapping technique was in good agreement with conventional clinical measures, such as interocular acuity difference (P < 0.001) and stereo acuity (P ¼ 0.005). There was a good consistency between the results of interocular suppression with dichoptic mapping paradigm and the results of the other two psychophysical methods (suppression mapping versus binocular phase combination, P < 0.001; suppression mapping versus global motion coherence, P ¼ 0.005).CONCLUSIONS. The dichoptic suppression mapping technique is an effective method to represent impaired visual function in patients with anisometropic amblyopia. It offers a potential in ''micro-''antisuppression mapping tests and therapies for amblyopia.

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Section: Discussionsupporting

confidence: 52%

Spatial and Global Sensory Suppression Mapping Encompassing the Central 10° Field in Anisometropic Amblyopia

Chen

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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“…30 The use of ND filters has also been advocated as a means of balancing the vision in the two eyes of amblyopic observers to promote better stereopsis. 31,32 Thus, optical defocus, Bangerter distortion, or methods producing overall luminance reduction 33 could all provide potential alternatives to full occlusion and result in better binocular outcomes. The second aim of this study was to compare all three of these partial occlusion techniques in observers with normal binocular vision to determine which allows for the most robust binocular function while still reducing the acuity in one eye.…”

Section: Discussionmentioning

confidence: 99%

Does Partial Occlusion Promote Normal Binocular Function?

Thompson

Ding

et al. 2012

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. There is growing evidence that abnormal binocular interactions play a key role in the amblyopia syndrome and represent a viable target for treatment interventions. In this context the use of partial occlusion using optical devices such as Bangerter filters as an alternative to complete occlusion is of particular interest. The aims of this study were to understand why Bangerter filters do not result in improved binocular outcomes compared to complete occlusion, and to compare the effects of Bangerter filters, optical blur and neutral density (ND) filters on normal binocular function.METHODS. The effects of four strengths of Bangerter filters (0.8, 0.6, 0.4, 0.2) on letter and vernier acuity, contrast sensitivity, stereoacuity, and interocular suppression were measured in 21 observers with normal vision. In a subset of 14 observers, the partial occlusion effects of Bangerter filters, ND filters and plus lenses on stereopsis and interocular suppression were compared. RESULTS.Bangerter filters did not have graded effect on vision and induced significant disruption to binocular function. This disruption was greater than that of monocular defocus but weaker than that of ND filters. The effect of the Bangerter filters on stereopsis was more pronounced than their effect on monocular acuity, and the induced monocular acuity deficits did not predict the induced deficits in stereopsis.CONCLUSIONS. Bangerter filters appear to be particularly disruptive to binocular function. Other interventions, such as optical defocus and those employing computer generated dichoptic stimulus presentation, may be more appropriate than partial occlusion for targeting binocular function during amblyopia treatment. (Invest Ophthalmol Vis Sci. 2012; 53:6818-6827)

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“…The dark blue regions within the deprivation datasets represent participants who had dense, congenital cataracts. Data from the following studies were included: Anisometropic ( n = 55; Agrawal et al, 2006; Li et al, 2011; Narasimhan et al, 2012), strabismic ( n = 47; Agrawal et al, 2006; Hess et al, 2009; Dallala et al, 2010; Narasimhan et al, 2012; Zhou et al, 2013), deprivation (unilateral n = 38, of which 20 were congenital, and bilateral n = 68, of which 42 were congenital; Tytla et al, 1993; Hwang et al, 1999; Zubcov et al, 1999; Robbins et al, 2010, 2012; Ing, 2011; Jeon et al, 2012). …”

Section: Local Processing Deficits In Amblyopiamentioning

confidence: 99%

Global processing in amblyopia: a review

et al. 2014

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Amblyopia is a neurodevelopmental disorder of the visual system that is associated with disrupted binocular vision during early childhood. There is evidence that the effects of amblyopia extend beyond the primary visual cortex to regions of the dorsal and ventral extra-striate visual cortex involved in visual integration. Here, we review the current literature on global processing deficits in observers with either strabismic, anisometropic, or deprivation amblyopia. A range of global processing tasks have been used to investigate the extent of the cortical deficit in amblyopia including: global motion perception, global form perception, face perception, and biological motion. These tasks appear to be differentially affected by amblyopia. In general, observers with unilateral amblyopia appear to show deficits for local spatial processing and global tasks that require the segregation of signal from noise. In bilateral cases, the global processing deficits are exaggerated, and appear to extend to specialized perceptual systems such as those involved in face processing.

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Latent Stereopsis for Motion in Depth in Strabismic Amblyopia

Cited by 32 publications

References 30 publications

Spatial and Global Sensory Suppression Mapping Encompassing the Central 10° Field in Anisometropic Amblyopia

Spatial and Global Sensory Suppression Mapping Encompassing the Central 10° Field in Anisometropic Amblyopia

Does Partial Occlusion Promote Normal Binocular Function?

Global processing in amblyopia: a review

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