Latent toxoplasmosis is associated with neurocognitive impairment in young adults with and without chronic HIV infection

Ene, Luminiţa; Marcotte, Thomas D.; Umlauf, Anya; Grancea, Camelia; Temereanca, Aura; Bharti, Ajay; Achim, Cristian L.; Letendre, Scott; Ruță, Simona

doi:10.1016/j.jneuroim.2016.08.003

Cited by 26 publications

(30 citation statements)

References 48 publications

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“…In a study based on behavioral and neurophysiological data obtained by means of a stop-change paradigm, researchers found that latent infection with T. gondii led to improved action control in healthy young humans [ 39 ]. This paradoxical improvement of cognitive control process of T. gondii infection contrasts with results of many reports where researchers found an impairment in neurocognitive and neurobehavioral functioning due to T. gondii infection [ 40–42 ]. For instance, latent toxoplasmosis was associated with neurocognitive impairment in young adults with and without chronic human immunodeficiency virus (HIV) infection [ 40 ].…”

Section: Discussioncontrasting

confidence: 94%

Toxoplasma gondii exposure and neurological disorders: An age- and gender-matched case-control pilot study

Alvarado‐Esquivel

Rico-Almochantaf

Hernández‐Tinoco

et al. 2017

EuJMI

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Little is known about the association of Toxoplasma gondii infection and neurological disorders. We performed a case-control study with 344 patients with neurological diseases and 344 neurologically healthy age- and gender-matched subjects. Sera of participants were analyzed for anti-T. gondii IgG and IgM antibodies using commercially available immunoassays. Anti-T. gondii IgG antibodies were detected in 25 (7.3%) cases and in 35 (10.2%) controls (odds ratio [OR] = 0.69; 95% confidence interval [CI]: 0.40–1.18; P = 0.17). Anti-T. gondii IgM antibodies were found in 5 (14.3%) of the 25 IgG seropositive cases and in 13 (37.1°%) of the 35 IgG seropositive controls (P = 0.15). Anti-T. gondii IgG antibodies were found in 8 (3.8%) of 213 female cases and in 23 (10.8%) of 213 female controls (OR = 0.32; 95% CI: 0.14–0.73; P = 0.005); and in 17 (13.0%) of 131 male cases and in 12 (9.2%) of 131 male controls (P = 0.32). No direct association between IgG seropositivity and specific neurological disorders was detected. We found no support for a role of latent T. gondii infection in the risk for neurological disorders in this setting. With respect to specific neurological disorders, further studies using larger patient cohorts will be required.

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Section: Discussioncontrasting

confidence: 94%

Toxoplasma gondii exposure and neurological disorders: An age- and gender-matched case-control pilot study

Alvarado‐Esquivel

Rico-Almochantaf

Hernández‐Tinoco

et al. 2017

EuJMI

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“…Thereafter, 9,130 records were excluded through an initial screening of the titles and/or abstracts. The remaining 85 full-text articles were assessed, out of which 27 studies were further compared against our inclusion criteria (Akgül, 2019;Alvarado-Esquivel et al, 2015;Alvarado-Esquivel et al, 2013;Ansari-Lari et al, 2017;Arling et al, 2009;Bak et al, 2018;Burgdorf et al, 2019;Coccaro et al, 2016;Coryell et al, 2016;Dickerson et al, 2018;Dickerson et al, 2017;Ene et al, 2016;Fond et al, 2015;Fond et al, 2018;Gale et al, 2016;Okusaga et al, 2011;Pedersen et al, 2012;Samojlowicz et al, 2013;Samojłowicz et al, 2017;Sapmaz et al, 2019;Sari & Kara, 2019;Sugden et al, 2016;Yagmur et al, 2010;Zhang et al, 2012). Finally, 26 data sets from the 25 records were included in this meta-analysis ( Figure 1).…”

Section: Study Characteristics and Search Resultsmentioning

confidence: 99%

“…The two other papers were non-comparative due to the lack of detailed information concerning the rate of T. gondii IgG antibodies to suicide, but no for IgM; therefore, they were ruled out of the quantitative analysis (Dickerson et al, 2017(Dickerson et al, , 2018. Information and characteristics of the selected studies which were included in the review are summarized in Tables 1 and 2. Out of 27 included studies, 12 articles were case-control studies (Alvarado-Esquivel et al, 2015;Alvarado-Esquivel et al, 2013;Ansari-Lari et al, 2017;Arling et al, 2009;Bak et al, 2018;Burgdorf et al, 2019;Coryell et al, 2016;Samojlowicz et al, 2013;Samojłowicz et al, 2017;Sari & Kara, 2019;Yagmur et al, 2010), 11 studies were cross-sectional (Akgül, 2019;Coccaro et al, 2016;Dickerson et al, 2017;Ene et al, 2016;Fond et al, 2015;Gale et al, 2016;Okusaga et al, 2011;Sapmaz et al, 2019;Zhang et al, 2012), and four were cohort studies (Dickerson et al, 2018;Fond et al, 2018;Pedersen et al, 2012;Sugden et al, 2016) (Table 1). As displayed in Table 2 for anti-T. gondii IgG, our meta-analysis of the 26 included data sets was performed on 64,159 individuals, including 3,804 patients with suicide disorders and 60,355 controls.…”

Section: Study Characteristics and Search Resultsmentioning

confidence: 99%

“…Of available data, the majority of the studies used enzyme-linked immunosorbent assay (ELISA) to identify anti-Toxoplasma antibodies (IgG and IgM) (Akgül, 2019;Ansari-Lari et al, 2017;Burgdorf et al, 2019;Coccaro et al, 2016;Coryell et al, 2016;Fond et al, 2015;Gale et al, 2016;Samojłowicz et al, 2017;Sapmaz et al, 2019;Sari & Kara, 2019;Yagmur et al, 2010;Zhang et al, 2012). In those studies, EIA (Alvarado-Esquivel et al, 2013Arling et al, 2009;Dickerson et al, 2017Dickerson et al, , 2018Ene et al, 2016;Fond et al, 2018;Okusaga et al, 2011;Pedersen et al, 2012;Sugden et al, 2016),…”

Section: Study Characteristics and Search Resultsmentioning

confidence: 99%

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Evolutionary puzzle of Toxoplasma gondii with suicidal ideation and suicide attempts: An updated systematic review and meta-analysis

Amouei

Moosazadeh

Nayeri

et al. 2020

Transbound Emerg Dis

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The World Health Organization has reported an annual global suicide rate of 14.5 per 100,000 people. On the other hand, it is estimated that approximately one‐third of the global population are infected with Toxoplasma gondii (T. gondii) parasite. It is widely assumed that microbial pathogens, such as T. gondii, are probably associated with affective and behavioural modulation. The present article aimed to assess the proposed role of toxoplasmosis in raising the risk of suicidal ideation (SI) and suicide attempts (SA) using the available epidemiological data. Seven major electronic databases and the Internet search engine Google were searched for all the studies published between the 1st of January 1950 and 31st of October 2019. The heterogeneity and the risk of bias within and across studies were assessed. Following data extraction, pooled odds ratios (ORs) with 95% confidence interval (CI) across studies were calculated using the random‐effects models. A total number of 9,696 articles were screened and 27 studies were regarded as eligible in our systematic review (SI with five papers and 22 papers on SA). A significant association was detected between antibodies against T. gondii with TA (ORs = 1.57; 95% confidence interval [CI] 1.23–2.00, p = .000). Exploration of the association between T. gondii and SA yielded a positive effect of seropositivity for IgG antibodies but not IgM. Despite the limited number of studies, a statistical association was detected between suicidal behaviours and infection with latent T. gondii.

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“…We established that these genes were involved in 71 biological/molecular pathways [ 68 ]. The top five are represented in Table 2 and it is revealed that these pathways offer functionality in neurocognitive disorders [ 69 , 70 , 71 , 72 , 73 , 74 ].…”

Section: Interaction Of Inhibitor Of Differentiation Proteins and mentioning

confidence: 99%

Contribution of Inhibitor of Differentiation and Estrogenic Endocrine Disruptors to Neurocognitive Disorders

et al. 2018

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The devastating growth in the worldwide frequency of neurocognitive disorders and its allied difficulties, such as decline in memory, spatial competency, and ability to focus, poses a significant psychological public health problem. Inhibitor of differentiation (ID) proteins are members of a family of helix-loop-helix (HLH) transcription factors. ID proteins have been demonstrated to be involved in neurodevelopmental and depressive diseases and, thus, may influence neurocognitive deficiencies due to environmental exposure. Previously, it has been demonstrated that environmental factors, such as estrogenic endocrine disruptors (EEDs), have played an essential role in the influence of various neurocognitive disorders such as Alzheimer’s, dementia, and Parkinson’s disease. Based on this increasing number of reports, we consider the impact of these environmental pollutants on ID proteins. Better understanding of how these ID proteins by which EED exposure can affect neurocognitive disorders in populations will prospectively deliver valuable information in the impediment and regulation of these diseases linked with environmental factor exposure.

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Latent toxoplasmosis is associated with neurocognitive impairment in young adults with and without chronic HIV infection

Cited by 26 publications

References 48 publications

Toxoplasma gondii exposure and neurological disorders: An age- and gender-matched case-control pilot study

Toxoplasma gondii exposure and neurological disorders: An age- and gender-matched case-control pilot study

Evolutionary puzzle of Toxoplasma gondii with suicidal ideation and suicide attempts: An updated systematic review and meta-analysis

Contribution of Inhibitor of Differentiation and Estrogenic Endocrine Disruptors to Neurocognitive Disorders

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