The lattice fracture model is a discrete model that can simulate the fracture process of cementitious materials. In this work, the Delft lattice fracture model is reviewed and utilized for fracture analysis. First, a systematic calibration procedure that relies on the combination of two uniaxial tensile tests is proposed to determine the input parameters of lattice elements—tensile strength, compressive strength and elastic modulus. The procedure is then validated by simulating concrete fracture under complex loading and boundary conditions: Uniaxial compression, three-point bending, tensile splitting, and double-edge-notch beam shear. Simulation results are compared to experimental findings in all cases. The focus of this publication is therefore not only on summarizing existing knowledge and showing the capabilities of the lattice fracture model; but also to fill in an important gap in the field of lattice modeling of concrete fracture; namely, to provide a recommendation for a systematic model calibration using experimental data. Through this research, numerical analyses are performed to fully understand the failure mechanisms of cementitious materials under various loading and boundary conditions. While the model presented herein does not aim to completely reproduce the load-displacement curves, and due to its simplicity results in relatively brittle post-peak behavior, possible solutions for this issue are also discussed in this work.