Lawsone derived Zn(ii) and Fe(iii) metal organic frameworks with pH dependent emission for controlled drug delivery

Abstract

Fluorescent biocompatible porous carriers have been investigated as suitable probes for drug delivery and sensing applications owing to their intrinsic fluorescence and high surface area originating from their porous structure...

Lawsone-bentonite hybrid systems for pH-dependent sustained release of ciprofloxacin

“…Cytocompatibility of the hybrids, QCB and QPB, was evaluated by MTT colorimetric assay in HOS cells following the standard procedure. 26 The samples were subjected to alcohol sterilization, followed by ultrasonication for 30 minutes prior to cell culture experiments. The cells at a density of 5 Â 10 3 cells per well were seeded in a 96 well plate and incubated for 24 h at 37 1C under a 5% CO 2 atmosphere before treatment with QCB and QPB (25, 50 and 100 mg mL À1 ).…”

“…22 More precisely, the noteworthy characteristics of lawsone are attributed not only to the production of new bioactive compounds but also employed as the starting material, with its stable enol form of a b-diketone, for the synthesis of interesting groups of hydroxyquinone derivatives either by O-alkylation or by C-alkylation and other complex structures with several biological activities. [23][24][25][26] The first attempt to alkylate lawsone has been reported by Fieser et al by reacting silver salt of lawsone with isoprenyl bromide, which resulted in both C-alkylated and O-alkylated products with very low yield. [27][28][29] Upon modifying reaction conditions and subsequent rearrangements, diverse products with varying quantitative yield were obtained.…”

“…22 More precisely, the noteworthy characteristics of lawsone are attributed not only to the production of new bioactive compounds but also employed as the starting material, with its stable enol form of a β-diketone, for the synthesis of interesting groups of hydroxyquinone derivatives either by O -alkylation or by C -alkylation and other complex structures with several biological activities. 23–26…”

The impact of MOFs in pH-dependent drug delivery systems: progress in the last decade

“…Crucially, intracellular pH is critical for cell function and regulation, where an abnormal pH value can indicate cellular functional abnormalities and serious diseases including cancer, stroke, Alzheimer's disease, neurodegenerative disorders, and cardiovascular disease. 49 The stimuli-responsive mechanism is another important component of DDSs given that it decides whether the DDS possesses controlled release capabilities. Controlled release behavior is dependent on a thorough understanding of the relevant stimuli signals and release mechanisms.…”

Palladium incorporated MIL-101(Cr): a heterogeneous and reusable catalyst for the C–H functionalization of unactivated arenes

“…5 Meanwhile, metal-organic frameworks (MOFs) are an important class of porous polymeric materials that have gained much attention because of their design and functionalization in accordance with current needs. 6 They have a wide application in catalysis, 7 drug delivery, 8 sensing, 9 gas storage, 10 etc., due to their high surface area, thermal stability, tunable pore size, etc. Thus, the functionalization of MOFs with active metal species is an advantageous approach in catalysis.…”