Layer‐by‐layer assembled hydrogel nanocomposite film with a high loading capacity

Abstract

The layer‐by‐layer assembly technique is a method that widely used in the preparation of nanostructured multilayer ultrathin films. We fabricated a hydrogel nanocomposite film by alternating the deposition of a core–shell poly[(dimethylimino)(2‐hydroxy‐1,3‐propanedily) chloride] (PDMIHPC)–laponite solution and poly(acrylic acid). The growth of the deposition procedure was proven by ultraviolet–visible spectroscopy and spectroscopic ellipsometry. The surface morphology of the films was observed by scanning electron microscopy. The films could reversibly load and release methylene blue (MB) dye, which was used as an indicator. It took about 4.5 h to reach loading equilibrium at pH 9.0. The loading capacity of the film for MB was as large as 4.48 μg/cm2 per bilayer because of the introduction of the core–shell PDMIHPC–laponite as a film component. Nearly 90% of MB was released at pH 3.0 or in a 300 mM NaCl solution within 2.5 h. The loading and release processes were greatly influenced by the ionic strength and pH value of the MB solution. The hydrogel nanocomposite film showed good pH‐triggered loading‐release reversibility and suggested potential applications in controlled drug‐delivery systems and smart materials. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 39352.

Nanocomposite Hydrogels: 3D Polymer–Nanoparticle Synergies for On-Demand Drug Delivery

“…68 The layer by layer assembly technique has also been used in the preparation of multilayer ultrathin films, obtaining hydrogel nanocomposite films with higher loading capacity. 69 The development self-healing hydrogels has also been discussed in this review. Self-healing materials are commonly found in living organisms, but this behavior is unusual in artificial systems.…”

“…The shrunk gel escapes from the dead cell, and it reproduces the process infecting a new cell . The layer by layer assembly technique has also been used in the preparation of multilayer ultrathin films, obtaining hydrogel nanocomposite films with higher loading capacity …”

Sorption/release of bioactive species in/from cross-linked poly(ethyleneimine)/poly(N-isopropylacrylamide) films constructed onto solid surfaces

“…Inorganic/organic composites with stable polymer layerby-layer (LbL) films on the surface have been used in controlled release of drugs, enzymes, dyes, genes, water purification, solid phase extraction, preparation of sensors, and catalysis. [1][2][3][4][5] From different synthesis methods of composite surfaces, the LbL strategy is the most versatile and used method to introduce complementary charged or functional groups onto inorganic surfaces. [6][7][8] An important task in construction of such composites is the stabilization of the organic part onto the inorganic one, thus the cross-linking step of polymer chains is crucial to achieve a composite surface with subsequent applications in different media.…”

“…[9][10][11][12] In the last years, attention has been paid to the loading/ release of bioactive compounds onto/from different multilayer assemblies. [13][14][15][16] The single component cross-linked multilayer thin films deposited onto silica microparticles were used in the loading of proteins, the final amount showing that the cross-linked multilayers act as protein reservoirs. 12 Using colloidal templates for LbL polymeric microarhitectures, in the last decade, many researchers synthesized hollow microcapsules as promising materials for drug delivery and release applications.…”