Layer-by-layer coated porous 3D printed hydroxyapatite composite scaffolds for controlled drug delivery

Chen, Shangsi; Shi, Yufei; Luo, Yun; Ma, Jun

doi:10.1016/j.colsurfb.2019.03.063

Cited by 49 publications

(24 citation statements)

References 38 publications

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“…In 2019, Chen et al reported that layer-by-layer coating of porous 3D-printed HAp composite scaffolds using chitosan and sodium hyaluronate could improve the sustained release of drugs from the scaffolds. They used two molecules, i.e., rhodamine B and BSA, to study drug release ability of the 3D-printed scaffolds; the results clarified that the size of molecules used can also affect the release rate (the larger molecule BSA shows faster release) (Chen et al, 2019c).…”

Section: Potential and Significance In Hard Tissue Regeneration And Dmentioning

confidence: 99%

Additive Manufacturing Methods for Producing Hydroxyapatite and Hydroxyapatite-Based Composite Scaffolds: A Review

et al. 2019

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Hydroxyapatite (HAp) has been considered for decades an ideal biomaterial for bone repair due to its compositional and crystallographic similarity to bioapatites in hard tissues. However, fabrication of porous HAp acting as a template (scaffold) for supporting bone regeneration and growth has been a challenge to biomaterials scientists. The introduction of additive manufacturing technologies, which provide the advantages of a relatively fast, precise, controllable, and potentially scalable fabrication process, has opened new horizons in the field of bioceramic scaffolds. This review focuses on three-dimensional-printed HAp scaffolds and related composite systems, where the calcium phosphate phase is combined with other ceramics or polymers improving the mechanical properties and/or imparting special extra-functionalities. The main applications of three-dimensional-printed HAp scaffolds in bone tissue engineering are presented and discussed; furthermore, this review also emphasizes the most recent achievements toward the development and testing of multifunctional HAp-based systems combining multiple properties for advanced therapy (e.g., bone regeneration, antibacterial effect, angiogenesis, and cancer treatment).

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Section: Potential and Significance In Hard Tissue Regeneration And Dmentioning

confidence: 99%

Additive Manufacturing Methods for Producing Hydroxyapatite and Hydroxyapatite-Based Composite Scaffolds: A Review

et al. 2019

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“…Hydroxyapatite (HAp,Ca 10 (PO 4 ) 6 (OH) 2 ) is a biomaterial found in bone and teeth, which has an apatite-like structure [1,2]. Because of its excellent chemical stability, biocompatibility, bioactivity, nontoxicity, and osteoconductivity, HAp has been used for the production of synthetic bone materials and bone and teeth implants and in drug delivery applications [2][3][4][5][6][7][8]. Studies have described diverse methods for synthesizing HAp, such as hydrothermal [9,10], sol-gel [11], microemulsion [12], precipitation [13], solid-state reaction [14], and microwave [15] methods.…”

Section: Introductionmentioning

confidence: 99%

“…These mechanical disadvantages can be overcome by adding a polymer. Thus, many studies have utilized natural polymers, such as collagen, chitosan, gelatin, alginate, and starch-based materials to modify HAp and produce high-quality HAp-bioceramics [8,[18][19][20][21][22][23]. Biopolymers have excellent biocompatibility, more biodegradability, and adequate osteoconductivity [17,24].…”

Section: Introductionmentioning

confidence: 99%

Effect of Temperature on Drug Release: Production of 5-FU-Encapsulated Hydroxyapatite-Gelatin Polymer Composites via Spray Drying and Analysis of In Vitro Kinetics

Aydın

2020

International Journal of Polymer Science

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In this study, 5-fluorouracil- (5-FU-) loaded hydroxyapatite-gelatin (HAp-GEL) polymer composites were produced in the presence of a simulated body fluid (SBF) to investigate the effects of temperature and cross-linking agents on drug release. The composites were produced by wet precipitation at pH 7.4 and temperature 37°C using glutaraldehyde (GA) as the cross-linker. The effects of different amounts of glutaraldehyde on drug release profiles were studied. Encapsulation (drug loading) was performed with 5-FU using a spray drier, and the drug release of 5-FU from the HAp-GEL composites was determined at temperatures of 32°C, 37°C, and 42°C. Different mathematical models were used to obtain the release mechanism of the drug. The morphologies and structures of the composites were analyzed by X-ray diffraction, thermal gravimetric analysis, Fourier transform infrared spectroscopy, and scanning electron microscopy. The results demonstrated that for the HAp-GEL composites, the initial burst decreased with increasing GA content at all three studied temperatures. Further, three kinetic models were investigated, and it was determined that all the composites best fit the Higuchi model. It was concluded that the drug-loaded HAp-GEL composites have the potential to be used in drug delivery applications.

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“…As well as in FDM, the drug is incorporated before extrusion [ 30 ]. In the last three years, the PAM technique has been employed in 8 studies with natural products to obtain drug delivery systems [ 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ]. These studies have been classified according to the nature of the natural product in 3D printed systems employing polysaccharides, proteins and lipids.…”

Section: Nozzle-based Deposition Systemsmentioning

confidence: 99%

3D Printed Drug Delivery Systems Based on Natural Products

et al. 2020

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In the last few years, the employment of 3D printing technologies in the manufacture of drug delivery systems has increased, due to the advantages that they offer for personalized medicine. Thus, the possibility of producing sophisticated and tailor-made structures loaded with drugs intended for tissue engineering and optimizing the drug dose is particularly interesting in the case of pediatric and geriatric population. Natural products provide a wide range of advantages for their application as pharmaceutical excipients, as well as in scaffolds purposed for tissue engineering prepared by 3D printing technologies. The ability of biopolymers to form hydrogels is exploited in pressure assisted microsyringe and inkjet techniques, resulting in suitable porous matrices for the printing of living cells, as well as thermolabile drugs. In this review, we analyze the 3D printing technologies employed for the preparation of drug delivery systems based on natural products. Moreover, the 3D printed drug delivery systems containing natural products are described, highlighting the advantages offered by these types of excipients.

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Layer-by-layer coated porous 3D printed hydroxyapatite composite scaffolds for controlled drug delivery

Cited by 49 publications

References 38 publications

Additive Manufacturing Methods for Producing Hydroxyapatite and Hydroxyapatite-Based Composite Scaffolds: A Review

Additive Manufacturing Methods for Producing Hydroxyapatite and Hydroxyapatite-Based Composite Scaffolds: A Review

Effect of Temperature on Drug Release: Production of 5-FU-Encapsulated Hydroxyapatite-Gelatin Polymer Composites via Spray Drying and Analysis of In Vitro Kinetics

3D Printed Drug Delivery Systems Based on Natural Products

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