Layered Double Hydroxides: A Novel Promising 2D Nanomaterial for Bone Diseases Treatment

Abstract

Bone diseases including bone defects, bone infections, osteoarthritis, and bone tumors seriously affect life quality of the patient and bring serious economic burdens to social health management, for which the current clinical treatments bear dissatisfactory therapeutic effects. Biomaterial‐based strategies have been widely applied in the treatment of orthopedic diseases but are still plagued by deficient bioreactivity. With the development of nanotechnology, layered double hydroxides (LDHs) with adjustable metal ion composition and alterable interlayer structure possessing charming physicochemical characteristics, versatile bioactive properties, and excellent drug loading and delivery capabilities arise widespread attention and have achieved considerable achievements for bone disease treatment in the last decade. However, to the authors' best knowledge, no review has comprehensively summarized the advances of LDHs in treating bone disease so far. Herein, the advantages of LDHs for orthopedic disorders treatment are outlined and the corresponding state‐of‐the‐art achievements are summarized for the first time. The potential of LDHs‐based nanocomposites for extended therapeutics for bone diseases is highlighted and perspectives for LDHs‐based scaffold design are proposed for facilitated clinical translation.

Recent advances using MXenes in biomedical applications

“…Environmentally-responsive 2D materials with a broad range of biomedical applications have been developed in previous studies. 17–21 For example, Shen and co-workers have shown that cobalt-molybdenum-based 2D layered double hydroxide (LDH) nanosheets (CoMo-LDH) can be used for photo-responsive dynamic therapy for cancer treatment. The CoMo-LDH nanosheets contain, by design, defects in the structure that enhance their photocatalytic and electrocatalytic activities.…”

Cobalt-doped layered hydroxide coating on titanium implants promotes vascularization and osteogenesis for accelerated fracture healing

“…Meanwhile, layered double hydroxides (LDHs) are a type of ionic compound, consisting of stacked positively charged layers separated by interlayer anions and water molecules. LDHs are an emerging class of inorganic biomaterials with high biocompatibility and unique functions, which have garnered significant interest for in vivo application [ 12 ]. The functional versatility offers tremendous opportunities for various biomedical applications such as drug delivery and bone tissue engineering [ 13 , 14 ].…”

Coordination-induced and tunable layered rare-earth hydroxide-complex intercalated nanohybrid phosphorescent photosensitizer and therapy

“…5,6 Among the myriad of matrixes, layered double hydroxides (LDHs, hydrotalcites) are widely selected as a two-dimensional host matrix to construct multicolor host-guest luminescent materials. [7][8][9] Hydrotalcites possesses the following advantages:…”