Layered MoS₂ Hollow Spheres for Highly‐Efficient Photothermal Therapy of Rabbit Liver Orthotopic Transplantation Tumors

Abstract

Combining photothermal therapy (PTT) with clinical technology to kill cancer via overcoming the low tumor targeting and poor therapy efficiency has great potential in basic and clinical researches. A brand-new MoS2 nanostructure is designed and fabricated, i.e., layered MoS2 hollow spheres (LMHSs) with strong absorption in near-infrared region (NIR) and high photothermal conversion efficiency via a simple and fast chemical aerosol flow method. Owing to curving layered hollow spherical structure, the as-prepared LMHSs exhibit unique electronic properties comparing with MoS2 nanosheets. In vitro and in vivo studies demonstrate their high photothermal ablation of cell and tumor elimination rate by single NIR light irradiation. Systematic acute toxicity study indicates that these LMHSs have negligible toxic effects to normal tissues and blood. Remarkably, minimally invasive interventional techniques are introduced to improve tumor targeting of PTT agents for the first time. To explore PTT efficiency on orthotopic transplantation tumors, New Zealand white rabbits with VX2 tumor in liver are used as animal models. The effective elimination of tumors is successfully realized by PTT under the guidance of digital subtraction angiography, computed tomography, and thermal imaging, which provides a new way for tumor-targeting delivery and cancer theranostic application.

Surface Nanopore Engineering of 2D MXenes for Targeted and Synergistic Multitherapies of Hepatocellular Carcinoma

“…Safe, stable, and highly efficient materials in nanomedicine have gained momentum in the treatment of various types of malignancies, including HCC. Aiming at the characteristic microenvironment of HCC, nanocarriers with excellent stability and targetability have been constructed, and their combinations with new therapeutic modalities such as sonodynamic, photodynamic, and photothermal therapy (PTT) have shown great potential in the treatment of HCC. PTT has been widely recognized with its minimal damage to normal tissues and high ablation efficacy, which is typically triggered by photothermal‐transducing agents (PTAs) under near infrared (NIR) laser to in situ generate heat for the thermal ablation of cancer cells .…”

Assembly of Au Plasmonic Photothermal Agent and Iron Oxide Nanoparticles on Ultrathin Black Phosphorus for Targeted Photothermal and Photodynamic Cancer Therapy

“…The mechanism of PDT involves energy transfer from the light‐excited PSs to oxygen and other molecules in the tissue to generate ROS, particularly singlet oxygen, which induces cellular toxicity . However, PTT usually relies on the photothermal agents that can transform strong absorbed light energy to heat, causing thermal ablation to target cells . Therefore, a higher therapy effect by combination of these two phototherapy methods under single light irradiation can be expected.…”

A Target‐Directed Chemo‐Photothermal System Based on Transferrin and Copolymer‐Modified MoS2 Nanoplates with pH‐Activated Drug Release

“…From the TEM image in Figure a, it was observed that the as‐prepared MoS 2 nanosheets were well dispersed with an average size of approximately 150 nm. The SAED (selected area electron diffraction) pattern in the inset of Figure a further confirmed that the obtained MoS 2 nanosheets owned hexagonal structure with (100), (110), (103), and (002) planes . The HRTEM (Figure b) image clearly showed well resolved lattice planes with average spacing of 0.27 and 0.65 nm, which corresponded to the (100) and (002) lattice spacing of the MoS 2 nanosheets, respectively.…”