2021
DOI: 10.1016/j.jpba.2020.113768
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LC and LC–MS/MS studies for identification and characterization of new degradation products of ibrutinib and elucidation of their degradation pathway

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Cited by 30 publications
(8 citation statements)
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“…Several documented drug examples are there in literature including acetaminophen (which on hydrolysis yields p-aminophenol and acetic acid), 27 chloramphenicol. 28 Formation of this product has also been previously reported 24,25 and very recently, as a common degradation product generated under both acidic and basic hydrolytic conditions.…”
Section: Lc-q/tof-ms Characterization Of Stress Degradation Productssupporting
confidence: 64%
“…Several documented drug examples are there in literature including acetaminophen (which on hydrolysis yields p-aminophenol and acetic acid), 27 chloramphenicol. 28 Formation of this product has also been previously reported 24,25 and very recently, as a common degradation product generated under both acidic and basic hydrolytic conditions.…”
Section: Lc-q/tof-ms Characterization Of Stress Degradation Productssupporting
confidence: 64%
“…In literature, there are several LC-MS/MS and HPLC methods available for analysis of degradation products of anticancer drugs. [12][13][14] The present work was designed to study in vitro metabolism of anticancer drug, belinostat using rat liver microsomes (RLM) and to characterize the formed metabolites using LC-MS/MS. The study also established the precise and rapid HPLC and LC-MS/ MS method to separate, identify and characterize the formed Phase-I metabolites of belinostat.…”
Section: Introductionmentioning
confidence: 99%
“…[16][17][18][19][20][21][22][23][24][25][26] Separation, identification and characterization of degradation products of few anticancer drugs using the UPLC-MSMS technique have been reported. [27][28][29][30] HPLC is now an outdated technology in terms of sensitivity and cost-effectiveness. Till date, no study is reported on the degradation and stability of drugs under varied conditions such as hydrolytic, oxidative, thermal and photolytic.…”
Section: Introductionmentioning
confidence: 99%