LC–DAD–ESIMS/MS characterization of antioxidant and anticholinesterase constituents present in the active fraction from Persicaria hydropiper

Hashim, Noor Haslinda Noor; Abas, Faridah; Shaari, Khozirah; Lajis, Nordin Hj

doi:10.1016/j.lwt.2011.11.021

Cited by 33 publications

(27 citation statements)

References 38 publications

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“…Noor Hashim et al [17] also reported the antioxidant activity of ethyl acetate fraction of methanol leaf extract against DPPH free radicals with IC 50 value of 13.30 μ g/mL, whereby the 3,5-dihydroxy-4-methoxybenzoic acid (IC 50 8.08 μ g/mL), quercetin (IC 50 11.14 μ g/mL), and quercetin-3- O -rhamnoside (IC 50 18.46 μ g/mL) were found to be most active as compared to vitamin C (IC 50 6.80 μ g/mL).…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

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Ethnobotanical, Phytochemical, Pharmacological, and Toxicological Aspects of Persicaria hydropiper (L.) Delarbre

Huq

Jamal

Stanslas

2014

Evidence-Based Complementary and Alternative Medicine

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Persicaria hydropiper (L.) Delarbre, belonging to Polygonaceae family, is a common weed found in most of the temperate countries including Bangladesh, China, Malaysia, and Japan. The plant is also referred to as “marsh pepper” or “smart weed.” It appears to be a useful herb with evidence-based medicinal properties. The present work addresses the botanical description, traditional uses, phytochemistry, pharmacology, and toxicology of P. hydropiper. All plant parts have been commonly used in the traditional systems of medicines. Flavonoids are the major group of phytochemical components followed by drimane-type sesquiterpenes and sesquiterpenoids, as well as phenylpropanoids. Different extracts and plant parts showed remarkable pharmacological activities including antioxidant, antibacterial, antifungal, antihelminth, antifeedant, cytotoxicity, anti-inflammatory, antinociceptive, oestrogenicity, antifertility, antiadipogenicity, and neuroprotection. Mutagenicity and acute and subchronic toxicities of the plant were also reported. P. hydropiper has tremendous medicinal properties that could further be investigated for the development of evidence-based herbal products.

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Section: Pharmacological Propertiesmentioning

confidence: 99%

“…However, the methanol extract, fractions (hexane, dichloromethane, ethyl acetate, butanol, and aqueous) and changweikangic acid A did not exhibit anticholinesterase activity [17, 42]. …”

Section: Pharmacological Propertiesmentioning

confidence: 99%

Ethnobotanical, Phytochemical, Pharmacological, and Toxicological Aspects of Persicaria hydropiper (L.) Delarbre

Huq

Jamal

Stanslas

2014

Evidence-Based Complementary and Alternative Medicine

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“…Research has been focused on the biological effects of plant's part, which have been used as cholinesterase inhibitors [9]. It lately has reported that P. hydropiper for antioxidant, anticholinesterase activities and its dynamic use for the treatment of neurodegenerative diseases [10].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of sedative and anxiolytic activities of methanol extract of leaves of Persicaria hydropiper in mice

Shahed-Al-Mahmud

Lina

2017

Clin Phytosci

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Background: Persicaria hydropiper Linn. (Family: Polygonaceae), it grows in damp places and the bank of rivers, canals, lakes, and roadsides of Bangladesh. The leaves of the plant used in traditional medicine to treat insomnia, depression, and neurodegenerative diseases. The objective of this study is to investigate the sedative and anxiolytic activities of the methanol extract of leaves of Persicaria hydropiper (MEPH).

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“…In traditional medicine, water-pepper has been used for treating cancer (8), hypertension, cardiovascular (9), hemostatic, diuretic, inflammatory (10) and skin diseases (11). The biological activities of water-pepper have been reported to include antioxidative (12), anti-tumor (13), anti-bacterial (14), anti-inflammatory (15), anti-tyrosinase (16), and anticholinesterase (17) activities. However, no study has yet been conducted to evaluate the collagenase inhibitory activity of water-peppers.…”

Section: Introductionmentioning

confidence: 99%

Collagenase inhibition by water-pepper (Polygonum hydropiper L.) sprout extract

Kawaguchi

Nagata²

2019

J Herbmed Pharmacol

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Introduction: Collagenase plays an important role in the degradation of dermal matrix proteins leading to wrinkle formation. The objectives of this study were to evaluate the inhibitory effect of water-pepper (Polygonum hydropiper L.) sprout extract on the activity of collagenase and to identify the inhibitory compounds.Methods: Collagenase inhibitory activity was measured by spectrophotometric assay. Activity-guided fractionation was performed using liquid-liquid extraction of water and n-butanol and Diaion HP-20 column chromatography, followed by high-performance liquid chromatography (HPLC) fraction collection.Results: A methanolic extract of water-pepper sprout inhibited collagenase activity in a concentration-dependent manner with an IC50 value of 156.7 μg/mL. Collagenase inhibitory activity (IC50 = 23.5 μg/mL) was found in 50% methanol eluate from the HP-20 column chromatography of the n-butanol soluble fraction. The active compound (IC50 = 1.9 μg/mL) in the eluate was isolated by HPLC and identified as quercetin-3-O-galactoside (hyperoside) from comparing retention time, UV-Vis absorption, and mass spectra with those of the standard. Lineweaver-Burk plots revealed that hyperoside was an uncompetitive inhibitor against collagenase. Hyperoside was also the most abundant flavonoid present in the methanolic extract.Conclusion: These results suggest that water-pepper sprouts could be beneficial as a natural source of collagenase inhibitor which might be used for the treatment of skin aging.

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LC–DAD–ESIMS/MS characterization of antioxidant and anticholinesterase constituents present in the active fraction from Persicaria hydropiper

Cited by 33 publications

References 38 publications

Ethnobotanical, Phytochemical, Pharmacological, and Toxicological Aspects of Persicaria hydropiper (L.) Delarbre

Ethnobotanical, Phytochemical, Pharmacological, and Toxicological Aspects of Persicaria hydropiper (L.) Delarbre

Evaluation of sedative and anxiolytic activities of methanol extract of leaves of Persicaria hydropiper in mice

Collagenase inhibition by water-pepper (Polygonum hydropiper L.) sprout extract

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