Evaluation of sedative and anxiolytic activities of methanol extract of leaves of Persicaria hydropiper in mice

Shahed-Al-Mahmud, Md.; Lina, Shah Marzia Mahjabin

doi:10.1186/s40816-017-0056-5

Cited by 32 publications

(20 citation statements)

References 17 publications

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“…After gavages, mice were preserved in different cages and given food as well as water as per need. Those mice were placed under observations for the post 72 hours of oral gavage to find out anomalies in behaviors, allergic reactions, and mortality [13].…”

Section: Acute Toxicity Studymentioning

confidence: 99%

In Vivo Sedative and Anxiolytic Activities of Thunbergia erecta (Acanthaceae) Leaves Activate Gamma-Aminobutyric Acid (GABA) Mediated Hyperpolarizationin Swiss Albino Mice

Begum¹,

Hossen²,

Moly³

et al. 2019

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Background: Thunbergia erecta (Acanthaceae) is the most abundant medicinal plant in different parts of Bangladesh where it is known as "nilghonta". It has been used as traditional medicine for insomnia, depression and anxiety management. However, no scientific evidence of T. erecta belonging to neuropharmacological activity has been reported. The aim of present study was to investigate in vivo sedative and anxiolytic activities of methanol extract from the leaves of T. erecta in Swiss Albino mice. Methods: Sedative activity of METE was investigated using open field, hole cross and thiopental sodium-induced sleeping time test model whereas anxiolytic activity was screened by elevated-plus maze, light-dark box, hole-board and marble-burying test method in mice at 200 and 400 mg/kg doses. The acute toxicity study and phytochemical analysis of METE also carried out. Diazepam used as the positive control for the following behavioral pharmacology test. Results: METE exhibited significant (p < 0.001) sedative effect by decreasing the number of (square and hole) crossed by mice in open field and hole cross tests in a dose-dependent (200 & 400 mg/kg) manner. In thiopental sodium-induced sleeping time test METE significantly (p < 0.001) shortened the latency period and prolonged the sleeping time in a dose dependent (200

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Section: Acute Toxicity Studymentioning

confidence: 99%

In Vivo Sedative and Anxiolytic Activities of Thunbergia erecta (Acanthaceae) Leaves Activate Gamma-Aminobutyric Acid (GABA) Mediated Hyperpolarizationin Swiss Albino Mice

Begum¹,

Hossen²,

Moly³

et al. 2019

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“…Medicinal plants have used from the ancestor as the antimicrobial agent in several parts of Bangladesh [10]. The antimicrobial activities of n-hexane, dichloromethane and methanolic extracts of the Plants of P. oleracea were examined in the present study (Table 3).…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial Activity of Methanol, n - Hexane and Dichloromethane Extract of Portulaca oleracea

Mahmud¹

2018

APCT

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Portulaca oleracea (Family: Portulacaceae). The antimicrobial activity was performed by disc diffusion method by determining the zone of inhibition of living microorganisms. The methanolic extract showed significant to mild antimicrobial activity than n-hexane and dichloromethane in compared with the standard drug Amoxicillin. The present study we used gram-positive (Klebsiella pneumoniae and Staphylococcus aureus) and gram-negative bacteria (Escherichia coli; Shigella boydii and Pseudomonas aeruginosa). The present results support the use of this plant in the treatment of diseases like abscesses, bilious conditions, and coughs in traditional medicine and also suggest the possibility of isolating antibacterial agents from P. oleracea.

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“…The biological effects of the A. trilobata extracts might be responsible for the GABA-A receptor, benzodiazepines, and nonbenzodiazepine agents. The anxiolytic and locomotor effects of benzodiazepines might result from the activation of glycine neurotransmitters in the brain [35,37].…”

Section: Discussionmentioning

confidence: 99%

Possible neuropharmacological effects of Adenia trilobata (Roxb.) in the Swiss albino mice model

et al. 2020

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Background Known colloquially as akandaphal in Bangladesh, Adenia trilobata has some traditional uses. Its leaves and stems are extracted with pure methanol (MEATL, MEATS) and fractioned by n-hexane (NFATL, NFATS). The in vivo anxiolytic activity was evaluated by elevated plus maze (EPM) testing and hole-board test (HBT), whilst the locomotor activity was examined using the open-field test (OFT) and hole-cross test (HCT) and the antidepressant activity was assessed with the forced swimming test (FST) and the tail suspension test (TST). Results Regarding the anxiolytic activity, the 400-mg/kg doses of MEATL, NFATL, MEATS and NFATS exhibited maximum percentages of entry into the open arm of 33.85%, 32.23%, 30.06% and 41.84%, respectively, compare with the diazepam (69.33%). During HBT, MEATL (400 mg/kg) and NFATL (400 mg/kg) demonstrated 51.67 ± 0.88 and 57.67 ± 3.18 instances of head-dipping relative to diazepam (64.33 ± 3.16), whilst the locomotor activity showed a dose-dependent reduction in square movements and number of hole crossings. During FST and TST, the NFATL (400 mg/kg) exhibited rates of 43.32% and 57.71% time spent immobile, whilst fluoxetine experienced rates of 54.79% and 55.74%. Conclusion Adenia trilobata could be a potential component for the treatment of neuropharmacological defects. Further study is required.

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Evaluation of sedative and anxiolytic activities of methanol extract of leaves of Persicaria hydropiper in mice

Cited by 32 publications

References 17 publications

<i>In Vivo</i> Sedative and Anxiolytic Activities of <i>Thunbergia erecta</i> (Acanthaceae) Leaves Activate Gamma-Aminobutyric Acid (GABA) Mediated Hyperpolarizationin Swiss Albino Mice

<i>In Vivo</i> Sedative and Anxiolytic Activities of <i>Thunbergia erecta</i> (Acanthaceae) Leaves Activate Gamma-Aminobutyric Acid (GABA) Mediated Hyperpolarizationin Swiss Albino Mice

Antimicrobial Activity of Methanol, n - Hexane and Dichloromethane Extract of Portulaca oleracea

Possible neuropharmacological effects of Adenia trilobata (Roxb.) in the Swiss albino mice model

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Evaluation of sedative and anxiolytic activities of methanol extract of leaves of Persicaria hydropiper in mice

Cited by 32 publications

References 17 publications

&lt;i&gt;In Vivo&lt;/i&gt; Sedative and Anxiolytic Activities of &lt;i&gt;Thunbergia erecta&lt;/i&gt; (Acanthaceae) Leaves Activate Gamma-Aminobutyric Acid (GABA) Mediated Hyperpolarizationin Swiss Albino Mice

&lt;i&gt;In Vivo&lt;/i&gt; Sedative and Anxiolytic Activities of &lt;i&gt;Thunbergia erecta&lt;/i&gt; (Acanthaceae) Leaves Activate Gamma-Aminobutyric Acid (GABA) Mediated Hyperpolarizationin Swiss Albino Mice

Antimicrobial Activity of Methanol, n - Hexane and Dichloromethane Extract of Portulaca oleracea

Possible neuropharmacological effects of Adenia trilobata (Roxb.) in the Swiss albino mice model

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<i>In Vivo</i> Sedative and Anxiolytic Activities of <i>Thunbergia erecta</i> (Acanthaceae) Leaves Activate Gamma-Aminobutyric Acid (GABA) Mediated Hyperpolarizationin Swiss Albino Mice

<i>In Vivo</i> Sedative and Anxiolytic Activities of <i>Thunbergia erecta</i> (Acanthaceae) Leaves Activate Gamma-Aminobutyric Acid (GABA) Mediated Hyperpolarizationin Swiss Albino Mice