LC-ESI-MS/MS and cytotoxic activity of three <i>Pistacia</i> species

Kirollos, F N; El‐Hawary, Seham S.; Salama, Osama; Elkhawas, Yasmin A.

doi:10.1080/14786419.2018.1428601

Cited by 22 publications

(16 citation statements)

References 13 publications

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“…Some studies ( Table 3 ) aimed to evaluate the anticancer potential of different phenolic extracts of this plant in vitro. The ethanolic leaf extracts showed anticancer potential against lung cancer A549, breast cancer MCF7, prostate cancer PC3, and HepG2 liver cancer in vitro [ 45 ]. Yemmen et al (2017) [ 60 ] revealed the anti-proliferative activities of leaf hydro-methanolic extracts against two human neuroblastoma cell lines (SK-N-BE(2) C and SH-SY5Y) with IC50 values of 100 μg/mL and 56 μg/mL, respectively.…”

Section: Prominent Pharmacological Activitiesmentioning

confidence: 99%

A Review of Pistacia lentiscus Polyphenols: Chemical Diversity and Pharmacological Activities

Sehaki

Jullian

Ayati

et al. 2023

Plants

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Pistacia lentiscus (lentisk) is a plant species of the Anacardiaceae family. It is a medicinal plant that grows wild in the Mediterranean region. This review aims to update the existing knowledge regarding P. lentiscus polyphenols by consulting references dated from 1996 to 2022. The data are organized and analyzed as follows: (i) to show the chemical diversity of phenolic products from P. lentiscus; (ii) to summarize the variability in phenolic composition and quantity; this could be attributed to plant origin, environmental conditions, phenological stage, and the polarity of the extraction solvents; (iii) to present the pharmacological properties in agreement with the traditional uses of this plant; and (iv) to demonstrate the correlation between the chemical profile and the pharmacological effect. Various compositions were observed, including phenolic acids, flavonoid glycosides, anthocyanins, catechins, and their derivatives. The biological and therapeutic potentials of lentisk extracts have been evaluated in terms of antioxidant, antimicrobial, and anti-inflammatory activities. Most of these activities are related to the phenolic composition of this plant. The content of this review will undoubtedly contribute to the choice of techniques for isolating the different bioactive molecules contained in the P. lentiscus. It is also of significance for the potential development of a micro-industrial sector based on the valorization of lentisk polyphenols.

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Section: Prominent Pharmacological Activitiesmentioning

confidence: 99%

A Review of Pistacia lentiscus Polyphenols: Chemical Diversity and Pharmacological Activities

Sehaki

Jullian

Ayati

et al. 2023

Plants

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“…In cell culture studies, mastic gum resin has shown anticancer effect in bile duct cancer (cholangiocarcinoma) (KMBC), pancreatic carcinoma (PANC-1), gastric adenocarcinoma (CRL-1739), and colonic adenocarcinoma (COLO205) cells [ 112 ]. P. lentiscus extract showed moderate activity against liver cancer [ 113 ] as well as breast cancer [ 114 , 115 ]. Raw and roasted pistachio showed a chemo-preventive potential regarding colon cancer [ 116 ].…”

Section: Health Benefits Of Pistachio Consumptionmentioning

confidence: 99%

Why Should Pistachio Be a Regular Food in Our Diet?

et al. 2022

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The pistachio is regarded as a relevant source of biologically active components that, compared to other nuts, possess a healthier nutritional profile with low-fat content composed mainly of monounsaturated fatty acids, a high source of vegetable protein and dietary fibre, remarkable content of minerals, especially potassium, and an excellent source of vitamins, such as vitamins C and E. A rich composition in terms of phytochemicals, such as tocopherols, carotenoids, and, importantly, phenolic compounds, makes pistachio a powerful food to explore its involvement in the prevention of prevalent pathologies. Although pistachio has been less explored than other nuts (walnut, almonds, hazelnut, etc.), many studies provide evidence of its beneficial effects on CVD risk factors beyond the lipid-lowering effect. The present review gathers recent data regarding the most beneficial effects of pistachio on lipid and glucose homeostasis, endothelial function, oxidative stress, and inflammation that essentially convey a protective/preventive effect on the onset of pathological conditions, such as obesity, type 2 diabetes, CVD, and cancer. Likewise, the influence of pistachio consumption on gut microbiota is reviewed with promising results. However, population nut consumption does not meet current intake recommendations due to the extended belief that they are fattening products, their high cost, or teething problems, among the most critical barriers, which would be solved with more research and information.

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“…Seven organic acid derivative compounds were identified by LC-QTOF-MS in the aqueous-alcoholic extract of P. (21,24,(26)(27)(28). Table 2 shows detailed information about the data of the molecules and fragments.…”

Section: Lc-qtof-ms Analysis Of Crude Extractmentioning

confidence: 99%

Investigation of Enzyme Inhibitory Activities, Antioxidant Activities, and Chemical Properties of Pistacia vera Leaves Using LC-QTOF-MS and RP-HPLC

2022

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: Since the leaves of some Pistacia species are used in traditional folk medicine for diabetes, this study investigated the in vitro antidiabetic effect (α-glucosidase and α-amylase) of Pistacia vera leaves. Additionally, the current study investigated the antihypercholesterolemic (cholesterol esterase), antiobesity (pancreatic lipase), and antioxidant activities (i.e., total antioxidant capacity, DPPH (2,2-Diphenyl-1-picrylhydrazyl) radical scavenging activity, metal chelating activity, and ferric-reducing antioxidant power) of P. vera leaves. The aqueous-alcoholic leaf extract inhibited α-amylase, α-glucosidase, and pancreatic lipase with the half-maximal inhibitory concentration values of 7.74 ± 0.72, 11.08 ± 3.96, and 168.43 ± 26.10 µg/mL, respectively. It was determined that the crude extract had high DPPH radical scavenging activity, ferric-reducing power, and moderate metal chelating activity. The ethyl acetate (EtOAc) subextract obtained by the liquid-liquid fractionation of the crude extract showed potent α-amylase and α-glucosidase inhibitory activities. The EtOAc subextract (5.794 ± 0.027 g/100 g subextract) was standardized by reversed-phase high-performance liquid chromatography based on β-pentagalloyl glucose, which showed inhibitory effects on both amylase and glucosidase enzymes. Fifteen compounds, seven of which are organic acid derivatives and eight of which are flavonoids, were identified by liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF-MS) analysis in the crude extract of P. vera leaves. Seven of the fifteen phenolic compounds detected in the crude extract by LC-QTOF-MS have both glucosidase and amylase inhibitory effects. As a result, P. vera leaves can be a potential source for compounds with high antioxidant effects that show inhibitory effects on enzymes involved in carbohydrate digestion in the prevention and treatment of diabetes or can be evaluated as a standardized extract.

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LC-ESI-MS/MS and cytotoxic activity of three Pistacia species

Cited by 22 publications

References 13 publications

A Review of Pistacia lentiscus Polyphenols: Chemical Diversity and Pharmacological Activities

A Review of Pistacia lentiscus Polyphenols: Chemical Diversity and Pharmacological Activities

Why Should Pistachio Be a Regular Food in Our Diet?

Investigation of Enzyme Inhibitory Activities, Antioxidant Activities, and Chemical Properties of Pistacia vera Leaves Using LC-QTOF-MS and RP-HPLC

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