LC/MS characterization of phenolic constituents of mate (Ilex paraguariensis, St. Hil.) and its antioxidant activity compared to commonly consumed beverages

Bravo, Laura; Goya, Luis; Lecumberri, Elena

doi:10.1016/j.foodres.2006.10.016

Cited by 286 publications

(279 citation statements)

References 62 publications

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“…Polyphenolic compounds found in mate differ significantly from green tea because mate leaves contain high concentrations of chlorogenic acid and no catechins [23]. Literature shows that I. paraguariensis is especially rich in chlorogenic acids [12,24], and in our work we proved that the selected plant belonging to the genus Ilex, possess a similar antioxidant pattern with high amounts of chlorogenic acid as well as its isomers and similar in chemical character diesters. It is worth noting that similar results were obtained by other researchers who studied yerba mate [17].…”

Section: Discussionsupporting

confidence: 63%

“…Bioactive compounds present in I. paraguariensis undergo modification according to extractive methods, genetic and environmental variability, and harvest time [12,13]. The extracts contain mainly polyphenols like chlorogenic acid, purine alkaloids (methylxanthines) such as caffeine and theobromine, flavonoids, a combination of vitamins, tannins and numerous triterpenic saponins derived from ursolic acid [5,7,14].…”

Section: Introductionmentioning

confidence: 99%

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Qualitative and quantitative analysis of polyphenolic compounds in Ilex Sp.

Zwyrzykowska

Kupczyński

Jarosz³

et al. 2015

Open Chemistry

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Qualitative and quantitative analysis of polyphenolic compounds in Ilex Sp. DOI: 10.1515/chem-2015-0142 received February 15, 2015 accepted October 1, 2015. Abstract: Natural compounds are an important source of desired biological activity which help to improve nutritional status, enhance productivity and bring many health benefits. The leaves of the Ilex paraguariensis (Aquifoliaceae) are used for preparing a beverage known as yerba mate and represent a proven source of natural polyphenols which are known to foster biological activity with the emphasis on antioxidant properties. In present work we focused on the polyphenolic content of air-dried leaves of Ilex aquifolium L., Ilex aquifolium 'Argentea Mariginata', Ilex meserveae 'Blue Angel', and a commercially available mate as the reference product. Liquid chromatography combined with mass spectrometry (HPLC and LC-MS) and thin layer chromatography (TLC), were used to establish polyphenolic substances content in aqueous methanolic extracts obtained from the biological matter. Up to 20 polyphenolic compounds were identified in the extracts, including rutin, quinic acid and its caffeoyl esters, i.e. chlorogenic acid and its isomers as well as dicaffeoyl derivatives. We took chlorogenic acid and rutin as reference compounds to quantify their levels in the extracts. It was determined that in all tested plants, high levels of these antioxidants were present. This led us to the conclusion that their leaves might serve as valuable food additives.

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Section: Discussionsupporting

confidence: 63%

Section: Introductionmentioning

confidence: 99%

Qualitative and quantitative analysis of polyphenolic compounds in Ilex Sp.

Zwyrzykowska

Kupczyński

Jarosz³

et al. 2015

Open Chemistry

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“…As in other quinic acid esters, the caffeoylquinic acids in the negative ion mode originate ions by two competing pathways (Fig. 1B); pathway I, with the ions Q 2 (m/z 173), C 1 (m/z 179) and C 2 (m/z 135) and pathway II, with the characteristic presence of the fragment Q 1 (m/z 191) (Bravo et al, 2007). For this compound, the presence of fragments at m/z 191 (100%) (MS 2 ) and m/z 173 (100%) (MS 3 ) seems to confirm the presence of a caffeoylquinic acid.…”

Section: Chlorogenic Acid Identification and Quantificationmentioning

confidence: 87%

“…1A), suggesting the presence of CGA as the most probable structure. The signal at m/z 707 was reported as a result of a dimeric adduct of the pseudo-molecular ion m/z 353, in the same analytical conditions (Bravo et al, 2007).…”

Section: Chlorogenic Acid Identification and Quantificationmentioning

confidence: 93%

Anti-inflammatory activity of Cymbopogon citratus leaves infusion via proteasome and nuclear factor-κB pathway inhibition: Contribution of chlorogenic acid

Francisco

Costa

Figueirinha

et al. 2013

Journal of Ethnopharmacology

112

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inflammatory activity of Cymbopogon citratus leaves infusion via proteasome and nuclear factor-κB pathway inhibition: contribution of chlorogenic acid, Journal of Ethnopharmacology, http://dx.doi.org/10. 1016/j.jep.2013.03.077 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Activation of nuclear factor-țB, a master regulator of inflammation, was investigated by Western blot and gene reporter assay. Proteasome activity was assessed using a fluorogenic peptide.Results: Cymbopogon citratus extract and its polyphenols inhibited the cytokine production on human macrophages. This supports the anti-inflammatory activity of Cy polyphenols in physiologically relevant cells. Concerning the effect on the activation of nuclear factor (NF)-țB pathway, the results pointed to an inhibition of LPS-induced NF-țB activation by Cy and PFs.Chlorogenic acid was identified, by HPLC/PDA/ESI-MS n , as the main phenolic acid of the Cy infusion, and it demonstrated to be, at least in part, responsible by that effect. Additionally, it was verified for the first time, that Cy and PFs inhibited the proteasome activity, a complex that controls NF-țB activation, having CGA a strong contribution. Conclusions:The results evidenced, for the first time, the anti-inflammatory properties of Cymbopogon citratus through proteasome inhibition and, consequently NF-țB pathway and cytokine expression. Additionally, Cy polyphenols, in particular chlorogenic acid, were highlighted as bio-active compounds.

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“…However, in most cases, the studies focus on identifying and/or quantification of terpenes (TAKETA et al, 2000 and2004), saponins (GNOATTO et al, 2005;PIRES et al, 1997;REGINATTO et al, 1999), polyphenols (BRAVO et al, 2007), methylxanthines (FILIP et al, 1998and 2010, REGINATTO et al, 1999 and flavonoids (TARRAGO et al, 2005, FILIP et al, 2010. In a previous study, Pires et al (1997) observed differences in the chemical composition of two species of Ilex (dumosa and paraguariensis), especially related to the concentration of saponins.…”

Section: Introductionmentioning

confidence: 99%

Analysis of volatile compounds of Ilex paraguariensis A. St. - Hil. and its main adulterating species Ilex theizans Mart. ex Reissek and Ilex dumosa Reissek

et al. 2011

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The adulteration of the product Ilex paraguariensis with other Ilex species is a mAjor problem for maté tea producers. In this work, three species of Ilex were evaluated for their volatile composition by headspace solid phase microextraction coupled to gas chromatography and mass spectrum detector (HS-SPME/GC-MS). The adulterating species I. dumnosa and I. theizans Mart. ex Reissek presented a different profile of volatile organic compounds when compared to I. paraguariensis. Aldehydes methyl-butanal, pentanal, hexanal, heptanal and nonanal were detected only in the adulterating species. This result suggests that such compounds are potential chemical markers for identification of adulteration and quality analysis of products based on Ilex paraguariensis.Index terms: Food analysis, food composition. RESUMOA adulteração do produto Ilex paraguariensis com outras espécies de Ilex é um dos principais problemas dos produtores de erva-mate. Neste trabalho, três espécies de Ilex foram avaliadas quanto à sua composição volátil por microextração em fase sólida acoplada à cromatografia gasosa e detector de espectro de massas (HS-SPME/GC-MS). As espécies adulterantes I. dumnosa e I. theizans Mart. ex Reissek apresentaram um perfil diferente de compostos orgânicos voláteis, quando comparadas com a I. paraguariensis. Os aldeídos metil-butanal, pentanal, hexanal, heptanal e nonanal foram detectados apenas nas espécies adulterantes. Esse resultado sugere que esses compostos químicos são marcadores potenciais para a identificação de adulteração e análise da qualidade dos produtos à base de Ilex paraguariensis.

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LC/MS characterization of phenolic constituents of mate (Ilex paraguariensis, St. Hil.) and its antioxidant activity compared to commonly consumed beverages

Cited by 286 publications

References 62 publications

Qualitative and quantitative analysis of polyphenolic compounds in Ilex Sp.

Qualitative and quantitative analysis of polyphenolic compounds in Ilex Sp.

Anti-inflammatory activity of Cymbopogon citratus leaves infusion via proteasome and nuclear factor-κB pathway inhibition: Contribution of chlorogenic acid

Analysis of volatile compounds of Ilex paraguariensis A. St. - Hil. and its main adulterating species Ilex theizans Mart. ex Reissek and Ilex dumosa Reissek

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