Le néphroblastome de l'adulte. À propos de trois cas

Tumor de Wilms del adulto

“…Comparativamente, el adulto con tumor de Wilms, tiene de forma significativa mucho peor pronóstico que el niño para cualquier estadio o histología 3 , habiendo estudios que reflejan sólo un 20% de pacientes libres de enfermedad a los tres años del tratamiento frente al 80% en la infancia 11 . Así mismo, el pronóstico es peor que el del carcinoma de células renales 12 . La extensión tumoral se produce por vía hemática y linfática, de modo que hasta un 25% de los adultos presentan metástasis en el momento del diagnóstico, sobre todo pulmonares, y cerca de un 30% tienen afectación ganglionar regional 3 .…”

Adult nephroblastoma

“…Wilms tumor (WT) or nephroblastoma, is one of the most frequent malignant renal tumor in children [1], it is extremely rare in adults, its incidence is 8 per million in children [2], whereas its incidence is lower than 0.2 per million per year in adults, There is no difference between histological features of nephroblastoma in children and in adults, Treatment guidelines for pediatric nephroblastoma are well established but are less clear for adults [1][2][3][4], in view of the rare occurrence of this tumor in adults it is extremely difficult to carry out randomized clinical trials and therapeutic guidelines have not been defined yet.…”

“…The prognosis for adult was reported to be worse than that for children [1,2] because Adult nephroblastoma has more aggressive behavior and shows worse therapeutic response [2]. In children the overall survival is 90% for stage I and 70% for stage IV, this decrease with 76 % for stage I and with 11% for stage IV in adult [4].…”