Le profil épidémiologique et biologique du cancer du sein à Fès-Boulemane (Maroc)

Abbass, F.; Bennis, S.; Znati, Kaoutar; Akasbi, Y.; Amrani, J.K.; Mesbahi, Omar El; Amarti, A.

doi:10.26719/2011.17.12.930

Cited by 14 publications

(8 citation statements)

References 9 publications

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“…Histologically, there was a preponderance of infiltrating ductal carcinomas with 94%, followed by infiltrating lobular carcinoma with 3.7% and metaplastic carcinoma with 1.7%. These results are comparable to the Moroccan and Cameroonian series but with different proportions [4] [18].…”

Section: Discussionsupporting

confidence: 84%

Epidemiological and Clinical Profile of Breast Cancer at Bamako Radiotherapy Center

Kone¹,

Diakité²,

Diarra³

et al. 2019

JCT

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Breast cancer is a major public health problem because of its incidence and mortality. Purpose: To establish the epidemiological and clinical characteristics of breast cancer seen at the radiotherapy center at the Mali Hospital of Bamako. Patients and methods: It was a retrospective, descriptive study of data from patients seen for breast cancer at the Center of Radiotherapy of Mali Hospital between April 2014 and December 2016. The parameters studied were: age, sex, family history of breast cancer, menopausal status, parity, breast tumor location, histological type, histological grade, cancer classification stage. Results: 134 cases of breast cancer were collected, with a frequency of 15%. The sex ratio (H/F) of 0.007. The patient's mean age was 47 ± 11 years old. The most represented age groups were 33-47 years old with 45.5% and 48-62 years old with 39%. Three percent (3%) of patients had a family history of breast cancer. Fifty (50%) of the patients were menopausal. The main clinical signs found were : mammary nodules (98%), mastodynia (65%), nodes (67%). Invasive ductal carcinomas were found in 94% of patients, followed by infiltrating lobular carcinomas with 3.7% and metaplastic carcinomas with 1.7%. SBR Grades II and III were mostly found with 37% and 23%. The average tumor size was 87 mm ± 43. Stage III was predominantly represented with 72%, followed by Stage II with 24% and Stages I and IV with 2% each. Conclusion: Breast cancer is common and reaches both before and after 50 years; the diagnosis is usually late; hence it is the importance of raising awareness and screening before the age of 50 and popularizing some complementary tests to better understand the prognosis of this disease and promote more targeted and conservative treatments that will improve survival.

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Section: Discussionsupporting

confidence: 84%

Epidemiological and Clinical Profile of Breast Cancer at Bamako Radiotherapy Center

Kone¹,

Diakité²,

Diarra³

et al. 2019

JCT

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“…In this study, young women under 40 years represent 24.9% of all women with breast cancer. Previous studies in Morocco reported disparate results, ranging from 8 to 25.4 [ 3 , 8 , 9 , 15 ]. Worldwide, the prevalence of breast cancer in young women is variable.…”

Section: Discussionmentioning

confidence: 99%

Outcome of Breast Cancer in Moroccan Young Women Correlated to Clinic-Pathological Features, Risk Factors and Treatment: A Comparative Study of 716 Cases in a Single Institution

et al. 2016

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BackgroundBreast cancer in young women is quite uncommon and shows more aggressive characteristics with major disparities between worldwide populations. Prognosis and outcome of breast cancer in young patients are widely studied, but still no consensus is available.MethodsWe retrospectively included 716 cases of breast cancer women diagnosed in 2009 at the National Institute of Oncology of Rabat. Patients were divided into two groups according to their age: women aged ≤40 years (Group 1) and women aged >40 years (Group 2). Data were recorded from patients’ medical files and analyzed using SPSS 13.0 software (IBM).ResultsYoung patients represent 24.9% of all patients with breast cancer. The comparison between the two groups displayed significant differences regarding nulliparity (p = 0.001) and progesterone receptor negativity (p = 0.01). Moreover, more progression (Metastases/Relapse) was registered in young women as compared to older women with breast cancer (p = 0.03).The estimated median follow-up period was 31 months. The 5-years Event-Free Survival (EFS) of patients with local disease was 64.6% in young women and 71.5% in older women with breast cancer (p = 0.04). Multivariate analysis in young women showed that nulliparity (HR: 7.2; 95%CI: 1.16–44.54; p = 0.03), T3 tumors (HR: 17.39; 95%CI: 1.74–173.34; p = 0.01) and negative PgR status (HR: 19.85; 95%CI: 1.07–366.54; p = 0.04) can be considered as risk factors for poorer event free survival while hormone therapy was associated with better EFS (HR: 0.11; 95%CI: 0.00–0.75; p = 0.03). In Group 2, multivariate analysis showed that patients with inflammatory breast cancer, N+ status, absence of radiotherapy, absence of chemotherapy, and absence of hormone therapy are at increased risk of recurrence.ConclusionsIn Morocco, breast cancer is more frequent in young women as compared to western countries. Breast cancer in young women is more aggressive and is diagnosed late, leading to an intensive treatment. Moreover, the main factors associated with breast cancer development in young women would be hormonal and reproductive status. Analysis of other genetic biomarkers is needed to explain the high prevalence of breast cancer in young women to improve breast cancer management in Morocco.

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“…Dalenc F et al [30] in France also noted a very large majority of HR+ tumors. Abbass et al [31] noted in their series that 72% of tumors were positive for hormone receptors. Concerning overexpression of Her-2/neu protein, our study reports a rate of 35.85%.…”

Section: Discussionmentioning

confidence: 94%

Clinical and Histological Profile of Breast Cancer at University Clinics of Kinshasa, Democratic Republic of Congo

Malingisi¹,

Andy²,

Alex³

et al. 2022

OJOG

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Context: Breast cancer represents a significant public health problem concern the world, given its frequency (20% to 25% of female cancers) and diagnosis clinical stage with a particular frequency of locally advanced cancers and inflammatory forms. Objectives: To describe the socio-demographic, clinical and histological characteristics of breast cancer at the University Clinics of Kinshasa. Methods: A descriptive and retrospective study was completed at University Clinics of Kinshasa from 1 January 2003 to 30 July 2018, including 300 cases of breast cancer diagnosed and treated. Results: The mean age of women at diagnosis was 47.5 ± 10.8 years. Most of the patients were married, multipara with an average parity of 3.7 ± 2.5 and non-menopausal. Breast mass was the main reason for medical visit (47.5%) and the majority of patients consulted 12 months after the onset of the disease (36.3%) at stage 3 (56%) and node extension was observed in 61.3%. The average size of the breast mass was 8.02 ± 3.7 cm. The infiltrating ductal carcinoma was the most common histological type in 82.5% of cases; the majority of tumors were histo-pronostic II in 47.5% of cases. 83% of the tumors were hormonal-dependent. Only 35.9% of the tumors over-expressed the HER 2/Neu receptor. Conclusion: Most patients consulted more than 12 months after the onset of the disease and the diagnosis was made at advanced stages. The tumor was large at diagnosis. The left breast was the most affected. The majority of tumors are of high histopronostic grade and are hormonal-dependent.

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Le profil épidémiologique et biologique du cancer du sein à Fès-Boulemane (Maroc)

Cited by 14 publications

References 9 publications

Epidemiological and Clinical Profile of Breast Cancer at Bamako Radiotherapy Center

Epidemiological and Clinical Profile of Breast Cancer at Bamako Radiotherapy Center

Outcome of Breast Cancer in Moroccan Young Women Correlated to Clinic-Pathological Features, Risk Factors and Treatment: A Comparative Study of 716 Cases in a Single Institution

Clinical and Histological Profile of Breast Cancer at University Clinics of Kinshasa, Democratic Republic of Congo

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