Le rôle du registre national REIN en France dans la veille sanitaire des patients en insuffisance rénale chronique terminale infectés par le SARS-CoV-2 : organisation et premières données

Lapalu, Sophie; Izaaryene, Ghizlane; Honoré, Nadia; Couchoud, Cécile; Rein, registre

doi:10.1016/j.nephro.2020.11.005

Cited by 7 publications

(3 citation statements)

References 14 publications

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“…Our study confirms the impact observed on the prevalence of COVID-19 in kidney transplant recipients (KTR) or chronic hemodialysis patients (34.6% vs 7.8%) [12]. The frequency of SARS-CoV-2 infection was approximately 1.8% of KTR patients and 4.9% of dialysis patients in the REIN cohort [13], while this incidence was 1.9% in the study of Ismail [14].Some studies have shown that most KTR with COVID-19 worldwide are men with an average age of over 50 years [15,16]. The average age of our patients was 34.1 ± 11.6 years (31.8% were aged≥ 50 years), of which 29 patients (69.5%) were men.…”

Section: Discussionsupporting

confidence: 86%

COVID-19 Infection in Kidney Transplant Recipients: Single-Center Study

M.,

N.,

et al. 2023

African Journal of Biology and Medical Research

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Introduction : Renal transplant recipients receiving chronic immunosuppression have been considered a population at high risk for infections, complications and death related to COVID-19 infection. Results: The average age of the patients was 37.3 ± 12.1 years, with a male predominance (65.9%). At least one comorbidity was observed in 41% of patients; obese (27.3%), diabetics (20.5%), cardiovascular diseases (6.8%), and cancers (2.2%). 90.1% of patients were hospitalized, of which 10% were admitted to the intensive care unit. Of the hospitalized patients, 10% died. Antimetabolites were reduced in 91% and stopped in 9% of patients. Calcineurin inhibitors were discontinued in 11.3% of patients. Hydroxychloroquine was administered in 23 patients (52.3%), antivirals in one patient (2.3%) and antibiotics in 56.8% of cases. Conclusion: Close monitoring of kidney transplant recipients is required during a pandemic due to a high mortality rate. The management of kidney transplant recipients has been difficult for clinicians and strategies are not based on high quality evidence.

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Section: Discussionsupporting

confidence: 86%

COVID-19 Infection in Kidney Transplant Recipients: Single-Center Study

M.,

N.,

et al. 2023

African Journal of Biology and Medical Research

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“…With the help of the REIN clinical research assistants, the nephrologists reported infection by SARS-CoV-2 in the registry in the presence of suspicious clinical symptoms, characteristic signs on CT chest scan or a positive RT-PCR result for SARS-CoV-2 on a nasopharyngeal swab. A form reporting their initial condition and outcome was filled in for each patient [ 9 , 10 ].…”

Section: Methodsmentioning

confidence: 99%

Long‐lasting clinical symptoms 6 months after COVID-19 infection in the French national cohort of patients on dialysis

Belkacemi¹,

Baouche

Gomis

et al. 2022

J Nephrol

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Background Systematic reviews have shown a high prevalence of long-term persistent sequelae after COVID-19. The aim of this study was to describe the prevalence and risk factors associated with long‐lasting clinical symptoms (LLCS) in survivors on chronic dialysis at 6 months after the onset of acute COVID-19 infection in the pre-vaccination period. Methods This national cohort study included all French patients on dialysis who had SARS-Cov-2 infection between March and December 2020 and who were alive and still on dialysis 6 months after infection. A form was filled in at 6 months concerning the presence of the following persistent symptoms: extreme fatigue, headache, muscle or weight loss of > 5%, respiratory sequelae, tachycardia, chest pain, joint or muscle pain, persistent anosmia or ageusia, diarrhea, sensory disorders, neuro-cognitive disorders, post-traumatic stress syndrome, depression, and anxiety. Results Complete survey results were available for 1217 patients (25.2% of those included); 216 (17.7%) had some LLCS. Probability of 6-month LLCS was higher in patients who were hospitalized in a medical or intensive care unit: OR 1.64 (95% CI 1.16–2.33) and 5.03 (2.94–8.61), respectively. Younger patients had a lower probability of LLCS. Each year on dialysis, as well as diabetes, overweight or obesity were associated with a higher probability of LLCS by 1.03 (1.01–1.06), 1.53 (1.08–2.17), 1.96 (1.10–3.52) and 2.35 (1.30–4.26), respectively. Conclusions This national study shows that at least one in six patients on dialysis who have COVID-19 will have LLCS. Systematic screening in dialysis patients would allow us to identify those who need more careful prevention and long-term care and to address them towards a rehabilitation pathway.

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“…Finally, the REIN registry, backed by its expertise and national network, was able to set up epidemiological monitoring of chronic dialysis and/or transplant patients affected by SARS-CoV-2 very quickly ( 95 ). A weekly newsletter has been set up (still on-going), sent to all nephrologists, using information transmitted by all the REIN research assistant working with the nephrologists in the regions.…”

Section: Prospects For Renal Registries and Researchmentioning

confidence: 99%

What does the French REIN registry tell us about Stage 4-5 CKD care in older adults?

Moranne

Hamroun²,

Couchoud³

2023

Front. Nephrol.

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The aim of this paper is to illustrate all the clinical epidemiology searches made within the French network REIN to improve CKD stage 4-5 care in older adults. We summarize various studies describing clinical practice, care organization, prognosis and health economics evaluation in order to develop personalized care plans and decision-making tools. In France, for 20 years now, various databases have been mobilized including the national REIN registry which includes all patients receiving dialysis or transplantation. REIN data are indirectly linked to the French administrative healthcare database. They are also pooled with data from the PSPA cohort, a multicenter prospective cohort study of patients aged 75 or over with advanced CKD, monitored for 5 years, and the CKD-REIN clinical-based prospective cohort which included 3033 patients with CKD stage 3-4 from 2013 to 2016. During our various research work, we identified heterogeneous trajectories specific to this growing older population, raising ethical, organizational and economic issues. Renal registries will help clinicians, health providers and policy-makers if suitable decision- making tools are developed and validated.

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Le rôle du registre national REIN en France dans la veille sanitaire des patients en insuffisance rénale chronique terminale infectés par le SARS-CoV-2 : organisation et premières données

Cited by 7 publications

References 14 publications

COVID-19 Infection in Kidney Transplant Recipients: Single-Center Study

COVID-19 Infection in Kidney Transplant Recipients: Single-Center Study

Long‐lasting clinical symptoms 6 months after COVID-19 infection in the French national cohort of patients on dialysis

What does the French REIN registry tell us about Stage 4-5 CKD care in older adults?

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