Le sac endolymphatique : ses fonctions au sein de l’oreille interne

Couloigner, V.; Teixeira, Marie; Sterkers, Olivier; Rask‐Andersen, Helge; Ferrary, Évelyne

doi:10.1051/medsci/2004203304

Cited by 38 publications

(14 citation statements)

References 37 publications

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“…The endolymphatic sac is thought to provide immunologic responses and maintain hydrostatic pressure and endolymph homeostasis for the inner ear (57). Loss of these functions may contribute to the etiopathophysiology of MD (57).…”

Section: Discussionmentioning

confidence: 99%

Endolymphatic Sac Surgery for Ménière’s Disease

Ak¹,

Lambert²,

Nguyen³

et al. 2014

Otology &Amp; Neurotology

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Endolymphatic sac surgery (sac decompression or mastoid shunt) is effective at controlling vertigo in the short term (>1 yr of follow-up) and long term (>24 mo) in at least 75% of patients with Ménière's disease who have failed medical therapy. Sac decompression and mastoid shunting techniques provide similar vertigo control rates. Mastoid shunting, with and without silastic, also provides similar vertigo control rates. Non-use of silastic, however, seems to maintain stable or improved hearing in more patients compared to silastic sheet placement. The data suggest that, once the sac is opened, placing silastic does not add benefit and may be deleterious.

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Section: Discussionmentioning

confidence: 99%

Endolymphatic Sac Surgery for Ménière’s Disease

Ak¹,

Lambert²,

Nguyen³

et al. 2014

Otology &Amp; Neurotology

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“…As to the mechanism underlying the development of EH, one possible factor is the release of chemical mediators, including histamine, serotonin, heparin, leukotriene, and so on, from mast cells in the endolymphatic sac. Because the endolymphatic sac is a key site not only in the inner ear immune defense (5,6) but also in the secretion and absorption of endolymph (18), chemical mediators released from mast cells might produce disturbances of the inner ear fluid homeostasis in the endolymphatic sac. Although H(1), H(2), and H(3) is only known as receptors of chemical mediators in the endolymphatic sac (19),the suppressive effect of LTRA on the development of EH indicates that leukotriene plays the most contributing role in the development of EH.…”

Section: Discussionmentioning

confidence: 99%

Type 1 Allergy-Induced Endolymphatic Hydrops and the Suppressive Effect of Leukotriene Receptor Antagonist

Takeda

Takeda²,

Egami³

et al. 2012

Otology &Amp; Neurotology

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“…Endolymphatic hydrops in the cochlea causes deafness, while endolymphatic hydrops in the vestibule causes vertigo (22, 31). Endolymph regulation is thus important for hearing and the sense of equilibrium (7,29). Although the ES is generally accepted to contain active ion transport systems and may absorb endolymph (11), no mechanisms of endolymph regulation by the ES have actually been established.…”

mentioning

confidence: 99%

Endolymphatic sac is involved in the regulation of hydrostatic pressure of cochlear endolymph

Inamoto

Miyashita

Akiyama

et al. 2009

American Journal of Physiology-Regulatory, Integrative and Comp

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To clarify the role of the endolymphatic sac (ES) in the regulation of endolymphatic pressure, the effects of isoproterenol, a ␤-adrenergic receptor agonist, and acetazolamide, a potent carbonic anhydrase inhibitor, both of which decrease ES direct current potential on cochlear hydrostatic pressure, were examined in guinea pigs. When isoproterenol was applied intravenously, hydrostatic pressures of cochlear endolymph and perilymph were significantly increased with no change in endocochlear potential or the hydrostatic pressure of cerebrospinal fluid. Acetazolamide produced no marked change in the hydrostatic pressure of cochlear endolymph. In ears with an obstructed ES, the action of isoproterenol on the hydrostatic pressure of cochlear endolymph and perilymph was suppressed. These results suggest that the ES may regulate the hydrostatic pressure of the endolymphatic system via the action of the agents such as catecholamines on the ES. direct current potential; isoproterenol; acetazolamide THE ENDOLYMPHATIC SAC (ES), which is a part of the inner ear, is believed to absorb endolymph, since surgical blockage of the ES and the endolymphatic duct causes accumulation of endolymph in the cochlea and vestibule, as so-called endolymphatic hydrops (11), a characteristic pathological finding in Meniere's disease. Endolymphatic hydrops in the cochlea causes deafness, while endolymphatic hydrops in the vestibule causes vertigo (22, 31). Endolymph regulation is thus important for hearing and the sense of equilibrium (7,29). Although the ES is generally accepted to contain active ion transport systems and may absorb endolymph (11), no mechanisms of endolymph regulation by the ES have actually been established.ES direct current potential (ESP) and endocochlear direct current potential (EP) are known to be present in the ES and the cochlea, respectively (3, 12, 15). ESP and EP are generated by active ion transports in the ES and cochlea, respectively (3, 15, 21). ESP and EP can thus be used as indices of function for the ES and cochlea, respectively (15, 21). Catecholamines reportedly depress ESP through ␤-adrenergic receptors (19). The finding that isoproterenol, a ␤-adrenergic receptor agonist, at a dose of 12.5 g/kg decreases ESP without changing EP (16), suggests that isoproterenol would suppress active ion transport in the ES without inhibiting active ion transport in the cochlea. Acetazolamide, a potent carbonic anhydrase inhibitor, reportedly depresses ESP more sensitively than EP (32, 33). The result that cotreatment with isoproterenol and acetazolamide at doses producing near-maximum reduction of ESP depresses almost all parts of the ESP, suggesting that isoproterenol and acetazolamide may depress ESP via different mechanisms and that ESP may be composed of isoproterenol-and acetazolamide-sensitive parts (17).The ES has been hypothesized to regulate endolymphatic hydrostatic pressure (4, 9). However, no reports have described hydrostatic pressure regulation by the ES, as direct measurement of endolymphatic hydrostatic ...

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Le sac endolymphatique : ses fonctions au sein de l’oreille interne

Cited by 38 publications

References 37 publications

Endolymphatic Sac Surgery for Ménière’s Disease

Endolymphatic Sac Surgery for Ménière’s Disease

Type 1 Allergy-Induced Endolymphatic Hydrops and the Suppressive Effect of Leukotriene Receptor Antagonist

Endolymphatic sac is involved in the regulation of hydrostatic pressure of cochlear endolymph

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