Leaching potential of nonsteroidal anti‐inflammatory drugs in soils

Xu, Jian; Wu, Laosheng; Chen, Weiping; Chang, Andrew C.

doi:10.1002/etc.107

Cited by 32 publications

(16 citation statements)

References 37 publications

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“…Although the Langmuir model does not completely explain the phenomenon, it was observed that the soil with the highest value of maximum adsorption, 76.6, corresponded to soil B, which was also the soil with the highest value of organic matter content, 3.51%, whereas soil C, with the lowest value of maximum adsorption, 38.2, was the soil with the lowest clay content, 15.0%. These results are to be expected because both organic matter and clay content are usually directly related to adsorption of contaminants in soils (Xu et al 2010), although other studies have reported that clay content does not play a major role (Lin and Gan 2011). It can be seen from the Freundlich adsorption parameters that adsorption was low, as indicated by the Freundlich constant, K Fads , with values between 1.05 and 2.26, similar to reported data for adsorption of ibuprofen on sediments (Styszko et al 2010).…”

Section: Resultsmentioning

confidence: 73%

Mobility of ibuprofen, a persistent active drug, in soils irrigated with reclaimed water

González-Naranjo¹,

Boltes²,

Biel³

2013

PLANT SOIL ENVIRON

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Ibuprofen is not completely removed in wastewater treatment plants, and consequently, it may enter the soil through irrigation with reclaimed water. Subsequently, due to the reversible adsorption which takes place in the soil, this emerging pollutant can become bioavailable for plants. The adsorption reversibility of this anti-inflammatory compound on four agricultural soils was quantified with adsorption-desorption experiments. The adsorption was found to be almost linear, with a minimum n ads of 0.76 and a maximum of 1.08. In contrast, desorption was nonlinear, with a n des which ranged from 0.84 to 2.75. The hysteresis index values were low, ranging from 0.42 to 0.66; hence the process takes place reversibly. In addition, ibuprofen was found to be moderately fixed in the soils studied, with organic carbon distribution coefficient (K OC ) values which ranged between 139.75 and 238.17 L/kg. Therefore, we conclude that this pollutant could be bioavailable for soil microorganisms or plants exposed to it and may reach groundwater by leaching.

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Section: Resultsmentioning

confidence: 73%

Mobility of ibuprofen, a persistent active drug, in soils irrigated with reclaimed water

González-Naranjo¹,

Boltes²,

Biel³

2013

PLANT SOIL ENVIRON

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“…The soil used in this study was characterized by a low content of organic matter and a high content of the sand fraction, which might result in a lower adsorption of NSAIDs to soil components and a higher availability of drugs for soil microorganisms (Xu et al, 2010; González-Naranjo et al, 2013; Vasiliadou et al, 2013; Estevez et al, 2014; Graouer-Bacart et al, 2016). This effect was also observed in relation to other organic compounds such as pesticides (Karpouzas and Walker, 2000; Liang et al, 2011; Cycoń et al, 2014), polycyclic aromatic hydrocarbons (Sverdrup et al, 2002; Rivas et al, 2008; Chen and Yuan, 2011) and other pharmaceuticals (Topp et al, 2008b; Sabourin et al, 2009; Al-Rajab et al, 2015; Barra Caracciolo et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…Based on the water solubility and mobility of pharmaceutical compounds and soil properties, NSAIDs may be adsorbed to soil particles, leached into ground water or runoff into surface water. It has been reported that the leaching of IBF, DCF, NPX, and KTF is significant and is related to their pK a values as well as to the amount of clay and dissolved organic carbon (Xu et al, 2010; Estevez et al, 2014). Studies by Chefetz et al (2008) proved that both the content and physicochemical nature of soil organic matter (SOM) strongly influenced the sorption of DCF and NPX in SOM-rich soil layers.…”

Section: Introductionmentioning

confidence: 99%

Variable Effects of Non-steroidal Anti-inflammatory Drugs (NSAIDs) on Selected Biochemical Processes Mediated by Soil Microorganisms

et al. 2016

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Non-steroidal anti-inflammatory drugs (NSAIDs) are the most frequently used group of pharmaceuticals. The high consumption and the uncontrolled disposal of unused drugs into municipal waste or their deposit in landfills can result in an increased concentration of these compounds in soils. Moreover, these drugs can affect the microbial activity. However, there is a lack of knowledge about these effects or it is very limited. Therefore, the objective of this study was to compare the impact of selected commercially available NSAIDs, i.e., diclofenac (DCF), naproxen (NPX), ibuprofen (IBF) and ketoprofen (KTP), applied at concentrations of 1 and 10 mg/kg soil, on the activity of soil microorganisms during the 90-day experiment. To ascertain this impact, substrate-induced respiration (SIR), soil enzyme activities, i.e., dehydrogenase (DHA), acid and alkaline phosphatases (PHOS-H and PHOS-OH) and urease (URE) as well as changes in the rates of nitrification and ammonification processes were determined. In addition, the number of culturable bacteria and fungi were enumerated. In general, the obtained data showed a significant stimulatory effect of NSAIDs on the microbial activity. Higher concentrations of NSAIDs caused a greater effect, which was observed for SIR, PHOS-H, PHOS-OH, URE, N-NO3- and N-NH4+, even during the whole incubation period. Moreover, the number of heterotrophic bacteria and fungi increased significantly during the experiment, which was probably a consequence of the evolution of specific microorganisms that were capable of degrading NSAIDs and used them as an additional source of carbon and energy. However, an inhibitory effect of NPX, IBF or KTP for SIR, DHA, on both phosphatases and culturable bacteria and fungi was observed at the beginning of the experiment. At lower concentrations of NSAIDs, in turn, the effects were negligible or transient. In conclusion, the application of NSAIDs altered the biochemical and microbial activity of soil what may cause the disturbance in soil functioning. It is reasonable to assume that some components of the NSAID formulations could stimulate soil microorganisms, thus resulting in an increase in biochemical activities of the soil.

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“…The behaviors of PPCPs in aquatic ecosystems are alarming (Onesios et al, 2009). The environmental fate and transport of the compounds in receiving soils need to be delineated (Xu et al, 2009b(Xu et al, , 2010.…”

Section: Introductionmentioning

confidence: 99%

Fates and transport of PPCPs in soil receiving reclaimed water irrigation

Chen

et al. 2013

Chemosphere

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h i g h l i g h t sBehaviors of 9 PPCPs in soil were evaluated by model validated with field data. Accumulation of PCPPs in the top 20 cm soil layer varied from <1 to about 140 ng g À1 . Extent that PPCPs were being transported downward by the drainage water was minor. Accumulation and leaching of PPCPs were highly dependent on the chemical nature. Normal reclaimed water irrigation did not appear to produce undue ecological risks. a r t i c l e i n f o t r a c tFates and transport of 9 commonly found PPCPs of the reclaimed water were simulated based on the HYDRUS-1D software that was validated with data generated from field experiments. Under the default scenario in which the model parameters and input data represented the typical conditions of turf grass irrigation in southern California, the adsorption, degradation, and volatilization of clofibric acid, ibuprofen, 4-tert-octylphenol, 4-n-nonylphenol, naproxen, triclosan, diclofenac sodium, bisphenol A and estrone in the receiving soils were tracked for 10 years. At the end, their accumulations in the 90 cm soil profile varied from less than 1 ng g À1 to about 140 ng g À1 and their concentrations in the drainage water in the 90 cm soil depth varied from nil to lg L À1 levels. The adsorption and microbial degradation processes interacted to contain the PPCPs entirely within surface 40 cm of the soil profiles. Leaching and volatilization were not significant processes governing the PPCPs in the soils. The extent of accumulations in the soils did not appear to produce undue ecological risks to the soil biota. PPCPs did not represent any potential environmental harm in reclaimed water irrigation.

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Leaching potential of nonsteroidal anti‐inflammatory drugs in soils

Cited by 32 publications

References 37 publications

Mobility of ibuprofen, a persistent active drug, in soils irrigated with reclaimed water

Mobility of ibuprofen, a persistent active drug, in soils irrigated with reclaimed water

Variable Effects of Non-steroidal Anti-inflammatory Drugs (NSAIDs) on Selected Biochemical Processes Mediated by Soil Microorganisms

Fates and transport of PPCPs in soil receiving reclaimed water irrigation

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