Lead Disrupts Mitochondrial Morphology and Function through Induction of ER Stress in Model of Neurotoxicity

Su, Peng; Xue, Chong; Wang, Diya; Zhao, Fang; Shen, Xuefeng; Luo, Wenjing

doi:10.3390/ijms231911435

Cited by 5 publications

(2 citation statements)

References 43 publications

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“…These findings suggest that Pb produces different results on glucose metabolism dependent on conditions such as exposure dose, nutritional conditions, exposure duration, age and sex of animals, and animal species. The use of 200 mg L −1 Pb acetate in the present study resulted in blood Pb levels of approximately 10 μg dL −1 in rodents, which be used to mimic the threshold for the human blood Pb level 51‐53 . We did not measure Pb levels in the blood, which is a limitation of our work.…”

Section: Discussionmentioning

confidence: 96%

Lead exposure aggravates glucose metabolism disorders through gut microbiota dysbiosis and intestinal barrier damage in high‐fat diet‐fed mice

Wang,

Gao,

Huo

et al. 2023

J Sci Food Agric

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BACKGROUNDLead (Pb) is an ancient toxic metal and is still a major public health issue. Our previous study found that Pb exposure promotes metabolic disorders in obese mice, but the molecular mechanisms remain unclear. The present study explored the effects of Pb exposure on glucose homeostasis in mice fed a normal diet (ND) and high‐fat diet (HFD) from the perspective of gut microbiota.RESULTSPb exposure had little effect on glucose metabolism in ND mice, but exacerbated hyperglycemia and insulin resistance, and impaired glucose tolerance in HFD mice. Pb exposure impaired intestinal tight junctions and mucin expression in HFD mice, increasing intestinal permeability and inflammation. Moreover, Pb exposure altered the composition and structure of the gut microbiota and decreased short‐chain fatty acids (SCFAs) levels in HFD mice. Correlation analysis revealed that the gut microbiota and SCFAs were significantly correlated with the gut barrier and glucose homeostasis. Furthermore, the fecal microbiota transplantation from Pb‐exposed HFD mice resulted in glucose homeostasis imbalance, intestinal mucosal structural damage and inflammation in recipient mice. However, Pb did not exacerbate the metabolic toxicity in HFD mice under depleted gut microbiota.CONCLUSIONThe findings of the present study suggest that Pb induces impairment of glucose metabolism in HFD mice by perturbing the gut microbiota. Our study offers new perspectives on the mechanisms of metabolic toxicity of heavy metals and demonstrates that the gut microbiota may be a target of action for heavy metal exposure. © 2023 Society of Chemical Industry.

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Section: Discussionmentioning

confidence: 96%

Lead exposure aggravates glucose metabolism disorders through gut microbiota dysbiosis and intestinal barrier damage in high‐fat diet‐fed mice

Wang,

Gao,

Huo

et al. 2023

J Sci Food Agric

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“…So most importantly, a high index of suspicion is needed since there may be no symptoms or overt clinical signs in those with mild disease [4]. But they already have shifts at the biochemical and cellular level, which can later be realized into a clear clinical picture of lead intoxication [7], such as neurotoxicity, change in psychological and behavioural development etc. [2].…”

Section: гігієна і організація охорони здоров'яmentioning

confidence: 99%

Спіруліна В Оздоровленні Дітей З Підвищеним Рівнем Свинцю В Крові

Гнідой,

Гніда

2023

Науковий вісник Ужгородського університету Серія Медицина

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Spirulina in the rehabilitation of children with elevated blood lead concentrationIntroduction. According to literary data, almost one in three children in the world has a blood lead concentration (BLC) of more than 5μg/ dL. This value is the threshold for initiating clinical intervention according to WHO recommendations. At this BLC threshold (referred to as the 'public health intervention concentration') public health action is recommended in the USA, Australia, France, England. In Ukraine, there are no programs of this scale yet. Scientific work in this direction is rare.The aim of the study was to evaluate the effectiveness of spirulina in improving the metabolic status in Ukrainian children with elevated BLC.Materials and methods. 33 random children aged 7 to 15 years were examined. The lead content in venous blood was detected by atomic absorption spectrometry with electrothermal atomization. Indicators of morphological and biochemical blood tests were determined by generally accepted methods.Results. About 30% of the children had BLC ≥ 5μg/dL. They had a lower content of hemoglobin and red blood cells, activation of lipid peroxidation processes and a decrease in antioxidant protection reserves compared to children with lower BLCs. According to the WHO recommendations, the children with BLC ≥ 5μg/dL underwent nutritional intervention. As a nutritional supplement, spirulina was used according to the scheme: the first 10 days -0.5 g 2 times a day, then 1 g 2 times a day for another 20 days. As a result, BLC significantly decreased from 7.56±0.20 to 6.26±0.57 μg/dL, hemoglobin increased from 126.91±2.15 to 137.46±1.46g/L, blood red cells increased from 4.02±0.07 to 4.39±0.05 T/L. The content of diene conjugants decreased from 20.46±1.71 to 13.82±1.27 μmol/L, and the number of sulfhydryl groups increased from 0.93±0.15 to 1.40±0.11μmol/L. The thiol-disulfide ratio increased 1.7 times.Conclusions. Spirulina contributes to the removal of lead from the body and helps to improve the metabolic status in children with elevated BLC. This allows us to recommend this dietary supplement for the rehabilitation of children undergoing environmental lead pressure.

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The enigma of mitochondrial epigenetic alterations in air pollution-induced neurodegenerative diseases

Acharyya,

Kumar,

Chouksey

et al. 2024

NeuroToxicology

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Lead Disrupts Mitochondrial Morphology and Function through Induction of ER Stress in Model of Neurotoxicity

Cited by 5 publications

References 43 publications

Lead exposure aggravates glucose metabolism disorders through gut microbiota dysbiosis and intestinal barrier damage in high‐fat diet‐fed mice

Lead exposure aggravates glucose metabolism disorders through gut microbiota dysbiosis and intestinal barrier damage in high‐fat diet‐fed mice

Спіруліна В Оздоровленні Дітей З Підвищеним Рівнем Свинцю В Крові

The enigma of mitochondrial epigenetic alterations in air pollution-induced neurodegenerative diseases

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