Lead poisoning with low blood lead levels

Torkington, P.; Bhalla, Khushboo

doi:10.1136/pgmj.50.582.240

Cited by 3 publications

(1 citation statement)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ll , 12 Chisolm et alP ,14 support the hypotheses that ALA in urine is a specific indicator of lead poisoning and that chelatable lead is clearly a valid indicator of internal dosage of 308 this metal and therefore an appropriate test to detect poisoning.…”

Section: Please Scroll Down For Articlementioning

confidence: 84%

Urinary δ-Aminolevulinic Acid as a Biological Indicator throughout Penicillamine Therapy in Lead Intoxication

Molina-Ballesteros¹,

Ma²,

Fj³

et al. 1978

Archives of Environmental Health: An International Journal

View full text Add to dashboard Cite

A group of 121 patients with occupational lead exposure was studied. Saturnism was confirmed in 42 of them. Patients were given D-penicillamine in doses of 0.75 and 1.5 g/day. Urinary delta-aminolevulinic acid was selected as a toxicity biological indicator; its concentrations were quantified daily during therapy. Urinary delta-aminolevulinic acid is considered a good biological indicator throughout penicillamine therapy and also in the detection of lead intoxication. Likewise, the chelating test is considered an excellent method to confirm the diagnosis of lead poisoning.

show abstract

Section: Please Scroll Down For Articlementioning

confidence: 84%

Urinary δ-Aminolevulinic Acid as a Biological Indicator throughout Penicillamine Therapy in Lead Intoxication

Molina-Ballesteros¹,

Ma²,

Fj³

et al. 1978

Archives of Environmental Health: An International Journal

View full text Add to dashboard Cite

show abstract

Interrelationships of glutathione reductase, 5‐aminolevulinic acid dehydratase, and free sulfhydryl groups in the erythrocytes of normal and lead‐exposed persons

Jk¹

1978

Journal of Toxicology and Environmental Health

View full text Add to dashboard Cite

Blood lead, erythrocyte glutathione reductase (GSSG-R), 5-aminolevulinic acid dehydratase (ALA-D), and free sulfhydryl (SH) groups were measured in normal subjects and in those with occupational exposure to lead. With increasing blood lead concentration the activity of GSSG-R rises and that of ALA-D decreases. There is also a fall in the level of free SH with rising blood lead concentrations. There is a high degree of correlation between these parameters, and it is suggested that the changes represent part of a biological control mechanism to compensate for the reduction of available sulfhydryl groups by lead ions.

show abstract

Measurement by ICP-MS of lead in plasma and whole blood of lead workers and controls.

et al. 1996

View full text Add to dashboard Cite

Objectives-To test a simple procedure for preparing samples for measurement of lead in blood plasma (P-Pb) and whole blood (B-Pb) by inductively coupled plasma mass spectrometry (ICP-MS), to measure P-Pb and B-Pb in lead workers and controls, and to evaluate any differences in the relation between B-Pb and PPb between people. Methods-P-Pb and B-Pb were measured by ICP-MS in 43 male lead smelter workers and seven controls without occupational exposure to lead. For analysis, plasma and whole blood were diluted 1 in 4 and 1 in 9, respectively, with a diluted ammonia solution containing Triton-X 100 and EDTA. The samples were handled under routine laboratory conditions, without clean room facilities. Results-P-Pb was measured with good precision (CV = 5%) even at concentrations present in the controls. Freeze storage of the samples had no effect on the results. The detection limit was 0*015 gye.The P-Pb was 0 15 (range 0.1-0.3) ug/l in controls and 1-2 (0.3-3.6) ug/l in lead workers, although the corresponding BPbs were 40 (24-59) ugll and 281 ug/l (1,ug Pb/l = 4'8 nmolIl). B-Pb was closely associated with P-Pb (r = 0.90).The association was evidently non-linear; the ratio B-Pb/P-Pb decreased with increasing P-Pb. Conclusions-By means of ICP-MS and a simple dilution procedure, P-Pb may be measured accurately and with good precision down to concentrations present in controls. Contamination of blood at sampling and analysis is no major problem. With increasing P-Pb, the percentage of lead in plasma increases. In studies of lead toxicity, P-Pb should be considered as a complement to current indicators of lead exposure and risk. (Occup Environ Med 1996;53:736-740)

show abstract

Lead poisoning with low blood lead levels

Cited by 3 publications

References 6 publications

Urinary δ-Aminolevulinic Acid as a Biological Indicator throughout Penicillamine Therapy in Lead Intoxication

Urinary δ-Aminolevulinic Acid as a Biological Indicator throughout Penicillamine Therapy in Lead Intoxication

Interrelationships of glutathione reductase, 5‐aminolevulinic acid dehydratase, and free sulfhydryl groups in the erythrocytes of normal and lead‐exposed persons

Measurement by ICP-MS of lead in plasma and whole blood of lead workers and controls.

Contact Info

Product

Resources

About