Lead toxicity on non-specific immune mechanisms of freshwater fish Channa punctatus

Paul, Nilantika; Chakraborty, Samujjwal; Sengupta, Mahuya

doi:10.1016/j.aquatox.2014.03.017

Cited by 77 publications

(45 citation statements)

References 48 publications

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“…The toxic effects usually associated with heavy metals exposure are carcinogenicity, immune-suppression and impaired reproduction [1,21,22] and the present experimental data, histological observations are providing evidences that the growth rate along with fecundity and GSI of IJASR|VOL 02|ISSUE 01|2016 www.ssjournals.com…”

Section: Histologysupporting

confidence: 59%

“…The effects of different toxicants on the aquatic fauna, particularly fish have received attention of many investigators [2,4,11,17,15,23,[28][29][30] as among animal species, fish are the inhabitants that cannot escape from the detrimental effects of these pollutants [8,22]. The toxicants like heavy metals after entering into aquatic environment accumulate in the tissues and organs of aquatic organisms.…”

Section: Introductionmentioning

confidence: 99%

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Lead induced histological alterations in ovarian tissue of freshwater teleost Mastacembelus pancalus (Hamilton)

Biswas¹,

Ghosh²

2016

Int J of Adv in Sci Res

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The Indian freshwater eel, Mastacembelus pancalus (Ham) was chronically exposed to lead nitrate for 30 days exposed at a dose of LC 20 value 18.5 mg/l (in respect to 925ppm 96-h LC 50 value). Results show reduced fecundity and GSI and deteriorated ootoxic conditions. Oolytic alteration includes lesion of oocytes, which resulted in dearth of any interfollicular spaces. Distorted appearance of oocytes was a major alteration observed. The effects of chronic exposure on growth and reproduction parameters were investigated in M. pancalus. The study demonstrated that lead can cause reproductive alteration in fishes. Present study insured that the gain in body weight and gonadal development along with egg laying capacity that is the fecundity and histological alteration of ovary of Mastacembelus pancalus is noticeably changed after 30 days exposure of lead. Lead exposure and growth rate, GSI were showed inverse relation. There were significant reduction on growth GSI, fecundity and histological attributes of the tissues of ovary due to chronic lead exposure. Exposure to lead can therefore, reduce fecundity of fish thereby can limit the numerical size of the succeeding generation.

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Section: Histologysupporting

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Lead induced histological alterations in ovarian tissue of freshwater teleost Mastacembelus pancalus (Hamilton)

Biswas¹,

Ghosh²

2016

Int J of Adv in Sci Res

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“…Therefore, oxidative stress and/or antagonism of Cadependent pathway have been proposed to be accountable for the lead-induced modulation of immune cells functions (Theron et al, 2012). Exposure to moderate level of Pb (9.43 mg/L) exhibited a reduction in TNF-α level in Channa punctatus (Paul et al, 2014). Exposure to moderate level of Pb (9.43 mg/L) exhibited a reduction in TNF-α level in Channa punctatus (Paul et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…2014), invariably persist in the environment (Paul, Chakraborty, & Sengupta, 2014) and poses a threat not only to the survival and health of aquatic organisms, but also to the fisheries and aquaculture industry and also to the consumer's health (through the food chain) (Sfakianakis, Renieri, Kentouri, & Tsatsakis, 2015).…”

mentioning

confidence: 99%

“…The consequences of lead exposure, in human and aquatic animals, have been demonstrated in a number of research papers, reviews and books, whom all are stated that lead exposure is associated with various adverse effects in many organ systems (Authman et al, 2015;Mishra, 2009;Mishra, Rani, Yadav, & Naik, 2010;Mitra et al, 2017;Sfakianakis et al, 2015). The immune system has been recognized to be one of the sensitive targets of lead toxicity, not only in human (Mishra, 2009;Mitra et al, 2017) but also in fish (Paul et al, 2014;Shah & Altindağ, 2005). Lead toxicity could induce modulation in the immune system of animals and human by effect on humoral B cells, T cells, natural killer cells, cytokine profile, chemotaxis, phagocytosis and nitric oxide production (Singh et al, 2003).…”

mentioning

confidence: 99%

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Immunomodulation by Coriandrum sativum seeds (Coriander) and its ameliorative effect on lead‐induced immunotoxicity in Nile tilapia ( Oreochromis niloticus L.)

2019

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The current study was carried out to evaluate the effects of dietary supplementation of Coriandrum sativum seed powder (CP) and extract (CE) on some immune functions of Oreochromis niloticus, without or with exposure to the immunotoxicant metal lead (Pb). Fish (n = 300) were divided into ten groups, in triplicate. First group (Cont) was fed on the basal control diet. Second (CP20) and third (CP30) groups were fed on CP‐supplemented diets at 20 mg/kg and 30 mg/kg respectively, while fourth (CE20) and fifth (CE30) groups were fed on CE‐supplemented diets at 20 mg/kg and 30 mg/kg respectively. Fish of the sixth (Cont‐Pb), seventh (CP20‐Pb), eighth (CP30‐Pb), ninth (CE20‐Pb) and tenth (CE30‐Pb) groups were exposed to lead (Pb) at 20.2 mg/L and received same diets presented to groups; Cont, CP20, CP30, CE20 and CE30 respectively. The experiment lasted for 45 days. CP and CE dietary supplementation not only significantly enhanced the immune functions, serum lysozyme, nitric oxide, bactericidal activities and relative expression of interleukin‐1β (IL‐1β) of O. niloticus in a concentration‐dependent manner, but also ameliorated the lead‐induced immunosuppressive effects, especially in CE30 received groups. Additionally, lead‐induced fish mortality and levels of lead residues in fish musculature were significantly reduced in response to feeding on CP‐ and CE‐supplemented diets, especially in CE30. Therefore, it could be concluded that coriander dietary supplementation, especially the extract (CE) at 30 mg/kg diet, could be used to enhance the immune response of O. niloticus and to counteract the immunotoxic effects of lead exposure.

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Lead and Aquatic Ecosystems, Biomarkers, and Implications for Humankind

Sarkar

Dey

Islam

et al. 2022

Biomarkers in Toxicology

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Lead toxicity on non-specific immune mechanisms of freshwater fish Channa punctatus

Cited by 77 publications

References 48 publications

Lead induced histological alterations in ovarian tissue of freshwater teleost Mastacembelus pancalus (Hamilton)

Lead induced histological alterations in ovarian tissue of freshwater teleost Mastacembelus pancalus (Hamilton)

Immunomodulation by Coriandrum sativum seeds (Coriander) and its ameliorative effect on lead‐induced immunotoxicity in Nile tilapia ( Oreochromis niloticus L.)

Lead and Aquatic Ecosystems, Biomarkers, and Implications for Humankind

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