LEADS: an interactive research oriented ECG/VCG analysis system

Draisma, Harmen H.M.; Swenne, Cees A.; Vooren, Hedde van de; Maan, Arie C.; Huysduynen, Bart Hooft van; Wall, Ernst E. van der; Schalij, Martin J.

doi:10.1109/cic.2005.1588151

Cited by 53 publications

(41 citation statements)

References 4 publications

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“…25 Subsequently, the ECGs were analyzed with a dedicated computer program (LEADS, Leiden ECG Analysis and Decomposition Software). 26 Full details on the computation method and LEADS based values of vector characteristics in healthy subjects have been extensively described earlier. 27 In short, the software converts the standard ECG into a vectorcardiogram and computes the 3D orientation of the QRS-and T-axes.…”

Section: Ecg Analysismentioning

confidence: 99%

Predicting Ventricular Arrhythmias in Patients With Ischemic Heart Disease

Borleffs

Scherptong

Man

et al. 2009

Circ: Arrhythmia and Electrophysiology

139

122

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Background-In patients with primary prevention implantable cardioverter-defibrillators (ICDs), the incidence of life-threatening ventricular arrhythmias resulting in ICD therapy is relatively low, prompting for better risk stratification. The aim of this study was to assess the value of the QRS-T angle for prediction of ICD therapy and mortality in primary prevention patients with ischemic heart disease. Methods and Results-ICD patients (nϭ412, 361 men; age, 63Ϯ11 years) with ischemic heart disease and a left ventricular ejection fraction Յ40% were included. After device implantation, the occurrence of appropriate ICD therapy and mortality was noted. A survival analysis was performed comparing patients with a planar QRS-T angle Յ90°( nϭ124, 30%) with patients with a planar QRS-T angle Ͼ90°before device implantation. Furthermore, patients with a spatial QRS-T angle Յ100°(nϭ56, 14%) were compared with patients with a spatial QRS-T angle Ͼ100°, before implantation. For patients with a planar QRS-T angle Ͼ90°as compared with Յ90°, the adjusted hazard ratio for the occurrence of appropriate device therapy was 2.4 (95% CI, 1.1 to 5.2); a spatial QRS-T angle Ͼ100°was associated with an adjusted hazard ratio of 7.3 (95% CI, 1.0 to 53.8). Furthermore, a spatial QRS-T angle Յ100°exhibited a positive predictive value of 98% (95% CI, 95 to 100) for the prediction of an appropriate therapy-free follow-up. Conclusions-A wide QRS-T angle is a strong predictor of appropriate device therapy in primary prevention ICD recipients with ischemic heart disease. Furthermore, a spatial QRS-T angle Յ100°might be of value in the identification of patients in whom, although currently indicated, ICD treatment should be reconsidered. (Circ Arrhythmia Electrophysiol. 2009;2:548-554.)

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Section: Ecg Analysismentioning

confidence: 99%

Predicting Ventricular Arrhythmias in Patients With Ischemic Heart Disease

Borleffs

Scherptong

Man

et al. 2009

Circ: Arrhythmia and Electrophysiology

139

122

View full text Add to dashboard Cite

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“…The Kors matrix was used to calculate vector cardiograms (VCG) from the eight independent ECG leads (22). ECGs and VCGs were analyzed using the automatic MATLAB-based (The MathWorks, Natick, MA) program BEATS and the semiautomatic program LEADS (23,24).…”

Section: Established and Novel Measures Of Sympathetic Activationmentioning

confidence: 99%

Body fat, especially visceral fat, is associated with electrocardiographic measures of sympathetic activation

Hillebrand

Mutsert

Christen

et al. 2014

Obesity

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Objective: Obesity is associated with sympathetic activation, but the role of different fat depots is unclear. The association between body fat, specifically visceral fat, and electrocardiographic measures of sympathetic activation in a population with structurally normal hearts was investigated. Methods: In this cross-sectional baseline analysis of the Netherlands Epidemiology of Obesity study, body fat percentage was assessed with BIA and abdominal subcutaneous (SAT) and visceral adipose tissue (VAT) with magnetic resonance (MR) imaging. Mean heart rate (HR) and five other electrocardiographic measures of sympathetic activation were calculated. We performed multivariate linear regression analyses. Results: In 868 participants with a mean age(SD) of 55(6) years, BMI of 26(4) kg/m 2 , 47% men, body fat was associated with HR and two other measures of sympathetic activation. Per sex-specific SD total body fat, the difference in HR was 1.9 beats/min (95% CI: 1.0, 2.9; P < 0.001) and per SD waist circumference 2.1 beats/min (95% CI: 1.3, 2.9; P < 0.001). The difference in HR per SD VAT was 2.1 beats/min (95% CI: 1.3, 3.0; P < 0.001). Conclusions: Body fat, especially visceral fat, was associated with electrocardiographic measures of sympathetic activation. Our study implies that already before the onset of cardiovascular disease, excess (visceral) body fat is associated with sympathetic activation.

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“…The ECGs were processed by our Matlab program LEADS [6]. This program performs a vectorcardiographic ECG analysis based on a synthesized vectorcardiogram (VCG).…”

Section: Methodsmentioning

confidence: 99%