Leakage index on ultra-widefield fluorescence angiography in different regions of retina and its correlation with cystoid macular edema in central retinal vein occlusion eyes

Wang, Xiaoling; Sun, Gongpeng; Yi, Zuohuizi; Xu, Amin; He, Lu; Jiang, Jingwen; Zheng, Hongmei; Chen, Changzheng

doi:10.1007/s00417-021-05126-y

Cited by 8 publications

(5 citation statements)

References 24 publications

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“…Leakage index is another useful parameter that has been recently studied in ultra-widefield fluorescein angiography. It is defined as the ratio of the leakage area to the total area and has been significantly correlated with the severity of cystoid ME 96…”

Section: Clinical Diagnosis and Multimodal Imagingmentioning

confidence: 99%

“…It is defined as the ratio of the leakage area to the total area and has been significantly correlated with the severity of cystoid ME. 96 For BRVO, studies have used modified criteria considering a retinal nonperfusion of ≥ 5 disc-diameters (DD) as a guide for stratifying NV risk in ischemic BRVO. 97,98 In fact, 36% of eyes with an area of nonperfusion of at least 5 DD had NV.…”

Section: Fundus Fluorescein Angiographymentioning

confidence: 99%

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Update on Retinal Vein Occlusion

Romanò

Lamanna

Gabrielle

et al. 2023

Asia-Pacific Journal of Ophthalmology

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Retinal vein occlusion represents the second leading cause of retinal vascular disorders, with a uniform sex distribution worldwide. A thorough evaluation of cardiovascular risk factors is required to correct possible comorbidities. The diagnosis and management of retinal vein occlusion have changed tremendously in the last 30 years, but the assessment of retinal ischemia at baseline and during follow-up examinations remains crucial. New imaging techniques have shed light on the pathophysiology of the disease and laser treatment, once the only therapeutic option, is now only one of the possible approaches with antivascular endothelial growth factors and steroid injections being preferred in most cases. Nowadays long-term outcomes are better than those achievable 20 years ago and yet, many new therapeutic options are under development, including new intravitreal drugs and gene therapy. Despite this, some cases still develop sight-threatening complications deserving a more aggressive (sometimes surgical) approach. The purpose of this comprehensive review is to reappraise some old but still valid concepts and to integrate them with new research and clinical data. The work will provide an overview of the disease's pathophysiology, natural history, and clinical features along with a detailed discussion on the advantages of multimodal imaging and of the different treatment strategies with the aim of providing retina specialists with the most updated knowledge in the field.

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Section: Clinical Diagnosis and Multimodal Imagingmentioning

confidence: 99%

Section: Fundus Fluorescein Angiographymentioning

confidence: 99%

Update on Retinal Vein Occlusion

Romanò

Lamanna

Gabrielle

et al. 2023

Asia-Pacific Journal of Ophthalmology

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“…Wang et al quantified leakage in various retinal zones on UWF FA in eyes with CRVO, and showed that greater leakage indices were significantly associated with the presence of CME. Furthermore, increased central macular thickness was correlated with pan-retinal leakage, peri-macular leakage, near-peripheral leakage, and mid-peripheral leakage, with the strongest correlation for peri-macular leakage ( 33 ).…”

Section: Ultra-widefield Fluorescein Angiographymentioning

confidence: 99%

Clinical utility of ultra-widefield fluorescein angiography and optical coherence tomography angiography for retinal vein occlusions

et al. 2023

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Retinal vein occlusions (RVOs) are the second most common retinal vascular disease after diabetic retinopathy, and are a significant cause of visual impairment, especially in the elderly population. RVOs result in visual loss due to macular ischemia, cystoid macular edema (CME), and complications related to neovascularization. Vascular assessment in RVOs traditionally relies on standard fluorescein angiography (FA) for assessment of macular and retinal ischemia, which aids in prognostication and guides intervention. Standard FA has significant limitations—it is time-consuming, requires invasive dye administration, allows for limited assessment of the peripheral retina, and is usually evaluated semi-qualitatively, by ophthalmologists with tertiary expertise. More recently, the introduction of ultra-widefield FA (UWF FA) and optical coherence tomography angiography (OCTA) into clinical practice has changed the tools available for vascular evaluation in RVOs. UWF FA allows for evaluation of peripheral retinal perfusion, and OCTA is non-invasive, rapidly-acquired, and provides more information on capillary perfusion. Both modalities can be used to provide more quantitative parameters related to retinal perfusion. In this article, we review the clinical utility and impact of UWF FA and OCTA in the evaluation and management of patients with RVOs.

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“…The acquisition of UWFFA has been noted in previous studies. 17,18 Image processing and analysis were conducted by two trained image analysts (G.S. and X.W.)…”

Section: Image Acquisition and Image Processingmentioning

confidence: 99%

Relationship Between Retinal Hemorrhage on Green and Red Channels of Ultra-Widefield Fundus Images and Retinal Perfusion in Acute Branch Retinal Vein Occlusion

Sun,

Wang,

et al. 2023

Retina

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Purpose: To explore the relationship between retinal hemorrhage in the green and red channels on ultra-widefield fundus images (UWFIs) and the nonperfusion area (NPA) on ultra-widefield fundus fluorescein angiography in patients with acute branch retinal vein occlusion (BRVO). Methods: This was a retrospective cross-sectional study with 96 patients, including 46 with ischemic BRVO and 50 with nonischemic BRVO. Correlation analysis between green channel hemorrhage (GCH), red channel hemorrhage (RCH), and NPA was performed. Panretina was divided into posterior and peripheral areas. Results: Ischemic BRVO showed significantly higher GCH% and RCH% than nonischemic BRVO in the peripheral regions (both P < 0.001), while no significant differences were observed in the panretinal and posterior area (all P > 0.05). Significant correlations were found between NPA% in the panretinal and peripheral areas and the corresponding GCH% and RCH% (all P < 0.01). However, no significant correlation was observed between posterior NPA% and posterior GCH% or RCH% (both P > 0.05). Additionally, peripheral GCH% and RCH% were related to panretinal NPA% (r = 0.506, P < 0.001; r = 0.558, P < 0.001). Conclusion: Retinal hemorrhage on UWFI was significantly associated with NPA, providing insights for assessing retinal perfusion status in acute BRVO patients.

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Leakage index on ultra-widefield fluorescence angiography in different regions of retina and its correlation with cystoid macular edema in central retinal vein occlusion eyes

Cited by 8 publications

References 24 publications

Update on Retinal Vein Occlusion

Update on Retinal Vein Occlusion

Clinical utility of ultra-widefield fluorescein angiography and optical coherence tomography angiography for retinal vein occlusions

Relationship Between Retinal Hemorrhage on Green and Red Channels of Ultra-Widefield Fundus Images and Retinal Perfusion in Acute Branch Retinal Vein Occlusion

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