Lean body mass and creatine kinase are associated with reduced inflammation in obesity

Bekkelund, Svein Ivar; Jorde, Rolf

doi:10.1111/eci.12802

Cited by 25 publications

(21 citation statements)

References 35 publications

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“…This result parallels the finding in a previous clinical study comparing CK and CRP in obese individuals [ 1 ]. In that study, which motivated the present one, CK and lean body mass were negatively associated with CRP indicating an inhibitory effect on obesity-related inflammation by CK and/or by other muscular metabolites [ 1 ]. The present study therefore supports an inverse relationship between CK and CRP by its presence in the general population, but an influence of obesity is not confirmed from these data.…”

Section: Discussionsupporting

confidence: 91%

“…Creatine kinase (CK), an enzyme promoting cellular energy metabolism mainly in skeletal muscles, has been associated with inflammation. Mechanisms to explain this are not established, but obesity is a possible link [ 1 ]. Plasma levels of inflammatory biomarkers predict obesity [ 2 – 4 ], and obesity-related inflammation is associated with increased risk of cardiovascular diseases (CVD) and CVD-mortality [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Accordingly, a higher CK-response was observed after performing eccentric exercise in elderly obese subjects with increased level of interleukin 6 [ 15 ]. Furthermore, CK along with lean mass were inversely and independently associated with C-reactive protein (CRP) in a sample of 454 overweight and obese individuals, supporting an anti-inflammatory role for CK [ 1 ]. Studies about how CK activity at rest associates with inflammation should also include non-obese populations.…”

Section: Introductionmentioning

confidence: 99%

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Creatine kinase is associated with reduced inflammation in a general population: The Tromsø study

Bekkelund

Johnsen

2018

PLoS ONE

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BackgroundCreatine kinase (CK) has been associated with reduced inflammation in obesity while inflammation is associated with obesity-related cardiovascular diseases. We investigated the relationship between CK and high sensitive C-reactive protein (hs-CRP) in a general population.MethodsCK and hs-CRP were measured in the population-based Tromsø study that included entire birth cohorts and random samples of citizens between 30–87 years of age. The analyses were performed sex-stratified in 5969 men and 6827 women.ResultsCK correlated negatively with hs-CRP in men (r = -0.08, P <0.001) and women (r = -0.06, P <0.001). In univariable regression analyses, CK associated negatively with hs-CRP in men (ß = -0.14, 95% CI -0.19 to -0.10, P <0.001) and women (ß = -0.13, 95% CI -0.18 to -0.08, P <0.001). Mean CK declined from the 2. to the 4. quartiles of hs-CRP in both genders (P <0.001 for trends). There were positive correlations between CK and body mass index (BMI) in men (r = 0.10, P <0.001) and women (r = 0.07, P <0.001). Multiple regression analyses showed a 0.13 unit decrease in hs-CRP (mg/dl) per unit CK increase in men (95% CI -0.35 to -0.20) and 0.29 mg/dl in women (95% CI -0.36 to -0.21) when adjusted for age, BMI, lipids, s-glucose, s-creatinine, transaminases and coronary heart disease.ConclusionCK were inversely and independently associated with hs-CRP in a general population. These data provide evidence that CK might have anti-inflammatory properties, but the mechanism and clinical implications are unclarified.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Creatine kinase is associated with reduced inflammation in a general population: The Tromsø study

Bekkelund

Johnsen

2018

PLoS ONE

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“…Additionally, previous studies show that plasma CK levels are associated with decreased inflammation in obesity, whereas higher inflammation is associated with higher obesity-related cardiovascular disease (CVD) [5][6][7]. Another study reported that plasma CK levels were inversely and independently associated with C-reactive protein in 454 overweight and obese individuals, supporting the anti-inflammatory effects of plasma CK levels [8]. Thus, plasma CK may have beneficial and detrimental effects on prognosis in the general population.…”

Section: Introductionmentioning

confidence: 93%

Plasma creatine kinase and all-cause mortality in patients on peritoneal dialysis: a multi-center retrospective study

Wen

Peng

Feng

et al. 2020

Preprint

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Background: Higher plasma creatine kinase (CK) values are associated with the failure of antihypertensive treatment. However, an association between CK and all-cause mortality in peritoneal dialysis (PD) patients has received little attention.Methods: In this retrospective multicenter study, 2224 incident PD patients with baseline CK values were enrolled from November 1, 2005, to February 28, 2017. All patients with oral statins were excluded and then were divided into four groups [Quartile 1 (<60 U/L), Quartile 2 (60-100 U/L), Quartile 3 (101-179 U/L), and Quartile 4 (>179 U/L)]. The primary endpoint was all-cause mortality. The association between plasma CK values and all-cause mortality was assessed with Cox regression and the Fine and Gray models.Results: Of eligible 1382 patients, 298 (21.6%) patients died during a median 35-month (interquartile range=19-54 months) follow-up period. Patients in Quartile 4 were older (P<0.001), more likely to be male (P<0.001), had a higher prevalence of diabetes (P=0.002), and a history of cardiovascular disease (P=0.005), and higher values of Charlson comorbidity index (P=0.031). All-cause mortality incidence had a significant difference among the four Quartiles (Quartile 1, 16.2%; Quartile 2, 22.2%; Quartile 3, 23.8%; Quartile 4, 24.1%; P=0.043). Quartile 4 had a higher all-cause mortality compared to other groups (Log Rank=10.55, P=0.015). After adjusting for confounding factors, the highest CK quartile had a hazard ratio (HR) for all-cause mortality of 1.72 [95% confidence interval (CI) 1.31-3.26, P=0.042]. With kidney transplantation or hemodialysis as a competing risk, the Quartile 4 had an HR for all-cause mortality of 1.64 (95%CI 1.25-3.48, P=0.046), after adjusting for confounding factors. Conclusions: Higher plasma CK levels at the commencement of PD may be a valuable biomarker for predicting the development of all-cause mortality in PD patients.

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“…On the other hand, plasma CK is associated with decreased inflammation in obesity, whereas higher inflammation is associated with higher obesity-related cardiovascular disease (CVD) [5][6][7]. Besides, CK and lean body mass were inversely and independently associated with C-reactive protein in 454 overweight and obese individuals, supporting the anti-inflammatory effects of plasma CK [8]. Thus, plasma CK may have beneficial and detrimental effects on prognosis in the general population.…”

Section: Introductionmentioning

confidence: 99%

Plasma creatine kinase and all-cause mortality in patients on peritoneal dialysis: a multi-center retrospective study

Wen

Peng

Feng

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Higher plasma creatine kinase (CK) values are associated with the failure of antihypertensive treatment. However, an association between CK and all-cause mortality in peritoneal dialysis (PD) patients has received little attention.Methods In this retrospective multicenter study, 1382 incident PD patients with baseline CK values were enrolled from November 1, 2005, to February 28, 2017. All patients with oral statins were excluded and then were divided into four groups according to quartile range [Quartile 1 (<60 U/L), Quartile 2 (60-100 U/L), Quartile 3 (101-179 U/L), and Quartile 4 (>179 U/L)]. The primary endpoint was all-cause mortality. The association between plasma CK values and all-cause mortality was assessed with Cox regression and the Fine and Gray models.Results Of 1382 patients 298 (21.6%) patients died during a median 35-month (interquartile range=19-54 months) follow-up period. Patients in Quartile 4 were older (P<0.001), likely to be male (P<0.001), had a higher prevalence of diabetes (P=0.002), and a history of cardiovascular disease (P=0.005), and higher values of Charlson comorbidity index (P=0.031). All-cause mortality incidence was a significant difference among the four Quartiles (Quartile 1, 16.2%; Quartile 2, 22.2%; Quartile 3, 23.8%; Quartile 4, 24.1%; P=0.043). Cumulative all-cause mortality in the Quartile 4 was significantly higher compared with other groups (Log Rank=10.55, P=0.015). After adjusting for confounding factors, the highest CK quartile had a hazard ratio (HR) for all-cause mortality of 1.75 [95% confidence interval (CI) 1.34-3.20, P=0.041]. With kidney transplantation or hemodialysis as a competing risk, the Quartile 4 had an HR for all-cause mortality of 1.66 (95%CI 1.30-3.41, P=0.044), after adjusting for confounding factors.Conclusions Higher plasma CK levels at the commencement of PD may be a valuable biomarker for predicting the development of all-cause mortality in PD patients.

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Lean body mass and creatine kinase are associated with reduced inflammation in obesity

Abstract: Inflammatory parameters were related to reduced lean mass and CK in an overweight and obese population. Hypothetically, lean mass has a favourable effect on obesity-related inflammation, and CK may play a role as an inhibitor of inflammation in obesity.

Cited by 25 publications

References 35 publications

Creatine kinase is associated with reduced inflammation in a general population: The Tromsø study

Creatine kinase is associated with reduced inflammation in a general population: The Tromsø study

Plasma creatine kinase and all-cause mortality in patients on peritoneal dialysis: a multi-center retrospective study

Plasma creatine kinase and all-cause mortality in patients on peritoneal dialysis: a multi-center retrospective study

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