Learned and cognitive controls of food intake

Benoit, Stephen C.; Davis, Jon F.; Davidson, Terry L.

doi:10.1016/j.brainres.2010.06.009

Cited by 65 publications

(55 citation statements)

References 60 publications

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“…The hippocampus is also involved in the cognitive regulation of feeding behavior such as remembering when one last ate, conditioned associations with food, remembering the interoceptive sensory cues and how to act on them etc. (23). …”

Section: Neural Responses To Proteinmentioning

confidence: 99%

The Macronutrients, Appetite, and Energy Intake

et al. 2016

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Each of the macronutrients, carbohydrate, protein and fat, has a unique set of properties that influence health, but all are a source of energy. The optimal balance of their contribution to the diet has been a long-standing matter of debate. Over the past half century, there has been a progression of thinking regarding the mechanisms by which each may contribute to energy balance. At the beginning of this time period, the emphasis was on metabolic signals that initiated eating events (i.e., determined eating frequency). This was followed by an orientation to gut endocrine signals that purportedly modulate the size of eating events (i.e., determined portion size). Most recently, research attention has been directed to the brain where the reward signals elicited by the macronutrients are viewed as potentially problematic (i.e., contribute to disordered eating). At this point the predictive power of the macronutrients for energy intake remains limited.

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Section: Neural Responses To Proteinmentioning

confidence: 99%

The Macronutrients, Appetite, and Energy Intake

et al. 2016

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“…Glial proteins were upregulated in the hippocampus, but not in the cerebellum, suggesting that the effects could be related to metabolic control, as the hippocampus is involved in food-seeking and food-memory behaviors (54,77), with leptin targeting this brain area and modulating these effects (77). Moreover, HFD modifies glutamate uptake and metabolism in the hippocampus (78).…”

Section: Figurementioning

confidence: 99%

Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes

Fuente-Martín¹,

García‐Cáceres²,

Granado³

et al. 2012

J. Clin. Invest.

174

186

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Glial cells perform critical functions that alter the metabolism and activity of neurons, and there is increasing interest in their role in appetite and energy balance. Leptin, a key regulator of appetite and metabolism, has previously been reported to influence glial structural proteins and morphology. Here, we demonstrate that metabolic status and leptin also modify astrocyte-specific glutamate and glucose transporters, indicating that metabolic signals influence synaptic efficacy and glucose uptake and, ultimately, neuronal function. We found that basal and glucose-stimulated electrical activity of hypothalamic proopiomelanocortin (POMC) neurons in mice were altered in the offspring of mothers fed a high-fat diet. In adulthood, increased body weight and fasting also altered the expression of glucose and glutamate transporters. These results demonstrate that whole-organism metabolism alters hypothalamic glial cell activity and suggest that these cells play an important role in the pathology of obesity.

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“…Neural processing in the hippocampus links contextual information with previous experience to guide behavior appropriately (17; 79; 91). This can influence feeding behavior not only based on external contextual cues (e.g., optimal foraging locations, feeding inhibition in predator environment), but also by integrating internal contextual cues with previous experience related to obtaining and/or consuming food.…”

Section: Central Glp-1 Regulation Of Blood Glucose and Energy Bamentioning

confidence: 99%

Incretins and Amylin: Neuroendocrine Communication Between the Gut, Pancreas, and Brain in Control of Food Intake and Blood Glucose

et al. 2014

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Arguably the most fundamental physiological systems for all eukaryotic life are those governing energy balance. Without sufficient energy, an individual is unable to survive and reproduce. Thus, an ever-growing appreciation is that mammalian physiology developed a redundant set of neuroendocrine signals that regulate energy intake and expenditure, which maintains sufficient circulating energy, predominantly in the form of glucose, to ensure that energy needs are met throughout the body. This orchestrated control requires cross-talk between the gastrointestinal tract which senses the incoming meal, the pancreas which produces glycemic counterregulatory hormones, and the brain which controls autonomic and behavioral processes regulating energy balance. Therefore, this review highlights the physiological, pharmacological, and pathophysiological effects of the incretin hormones glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP), as well as the pancreatic hormone amylin, on energy balance and glycemic control.

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Learned and cognitive controls of food intake

Cited by 65 publications

References 60 publications

The Macronutrients, Appetite, and Energy Intake

The Macronutrients, Appetite, and Energy Intake

Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes

Incretins and Amylin: Neuroendocrine Communication Between the Gut, Pancreas, and Brain in Control of Food Intake and Blood Glucose

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