Learning and memory: regional changes in N-methyl-D-aspartate receptors in the chick brain after imprinting.

McCabe, Brian J.; Horn, G.

doi:10.1073/pnas.85.8.2849

Cited by 285 publications

(107 citation statements)

References 34 publications

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“…In the cortex of mammals, the findings from electrophysiological (Cepeda et al, 1992;Pralong and Jones, 1993) and from ultrastructural (Smiley et al, 1992(Smiley et al, , 1994Smiley and GoldmanRakic, 1993) studies have also suggested a modulatory role for DA and D1 receptors on glutamatergic transmission. Recent microdialysis experiments in the MNH of domestic chicks revealed a modulatory influence of dopamine on the release of glutamate (Gruss et al, 1994), which has been shown to play a crucial role in neuronal plasticity in relation to filial imprinting (McCabe and Horn, 1988;McCabe et al, 1992;Wang et al, 1994;Bock et al, 1996Bock et al, , 1997. Furthermore, there is evidence that changes of dopaminergic mechanisms occur during juvenile learning, which may be relevant for the recall of learned information.…”

Section: Possible Involvement Of Dopaminergic Mechanisms In Juvenile mentioning

confidence: 95%

Localization of dopamine D1 receptors and dopaminoceptive neurons in the chick forebrain

et al. 1997

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The distributions of dopamine D1 receptors, dopaminoceptive neurons, and catecholaminergic fibers were investigated in the forebrain of the domestic chick by using D1 receptor autoradiography and immunohistochemical detection of D1 receptor protein (D1rp), the dopamine- and cAMP-regulated phosphoprotein DARPP-32, and tyrosine hydroxylase (TH). Particular attention was paid to two forebrain regions, the mediorostral neostriatum/ hyperstriatum ventrale (MNH) and neostriatum dorsocaudale (Ndc), which have been shown to be crucially involved in filial imprinting. In general, there was a good, but not complete, correlation between the immunohistochemical pattern of DARPP-32 positive perikarya and the distribution of D1 receptors. Both, DARPP-32 positive neurons as well as D1 receptors were highly enriched in the striatal part of the basal ganglia including the lobus parolfactorius (LPO) and paleostriatum augmentatum. High to moderate densities were observed in the outer rind of the pallium. Low to moderate densities were found in the belt regions of primary sensory areas, whereas densities in the respective core regions were generally low. Labeling in the MNH and Ndc was heterogeneous. Whereas the neostriatal part of MNH displayed both, moderate DARPP-32 immunostaining and moderate D1 receptor densities, the hyperstriatal part showed also moderate D1 receptor densities but was only weakly labeled by DARPP-32. The rostral part of the Ndc was among the most intensely DARPP-32 labeled areas of the pallium, its caudal part revealed only moderate DARPP-32 immunostaining. By using D1 receptor autoradiography, a homogeneous labeling throughout the rostrocaudal extension of the Ndc was found. Double-labeling experiments with antibodies to DARPP-32 and TH revealed that TH positive fibers in the MNH, Ndc, and LPO were often closely related to DARPP-32 positive perikarya. At the ultrastructural level, both immunoreaction for D1rp and DARPP-32 in the MNH and Ndc were primarily found to be associated with postsynaptic elements. Whereas D1rp immunoreactivity was enriched at postsynaptic densities or in their vicinity, reaction product for DARPP-32 was present throughout the perikaryal cytoplasm, dendrites, and dendritic spines. These results indicate that DARPP-32 as well as D1 receptors in the avian forebrain reveal a distribution that is substantially similar to that of mammals.

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Section: Possible Involvement Of Dopaminergic Mechanisms In Juvenile mentioning

confidence: 95%

Localization of dopamine D1 receptors and dopaminoceptive neurons in the chick forebrain

et al. 1997

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“…In comparison to the wild rock dove, domesticated pigeons exhibit this plasticity of the ventral hyperstriatum [Ebinger and Löhmer, 1984], and the same is true for homing pigeons, whose ventral hyperstriatum is larger than that in non-homing breeds [Rehkämper et al, 1988]. McCabe and Horn [1988] have drawn attention to the ventral hyperstriatum with respect to learning and associated cognitive behavior. Thus, one might hypothesize that the relatively large brain in crested chickens positively influences their learning capacity.…”

Section: Brain Part Sizementioning

confidence: 99%

Allometric Comparison of the Brain and Brain Structures in the White Crested Polish Chicken with Uncrested Domestic Chicken Breeds

Frahm

Rehkämper²

1998

Brain Behav Evol

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The feather crest on the head of the White Crested Polish Chicken covers a bony protuberance, a skull modification typical of crested chickens. The telencephalon is displaced into this protuberance, giving the brain the shape of an hour-glass. Allometric comparison (i.e., consideration of the influence of body weight on brain size) shows that the brain is relatively larger in crested chickens. This enlargement is partly due to enlarged ventricles, which are observed in some individuals. Among the brain structures measured, the tegmentum, cerebellum, tectum, paleostriatum, hippocampus, septum and olfactory bulb are not significantly larger in White Crested Polish chickens in comparison to those structures in seven uncrested chicken breeds; the optic tract, diencephalon, telencephalon, accessory hyperstriatum, dorsal and ventral hyperstriatum, and neostriatum, however, are significantly enlarged in this breed.

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“…with learning) and changes in this binding could not be attributed solely to light exposure, locomotor activity during training or related side-effects of the training procedure (McCabe & Horn, 1988). The results of the present study suggest that the learning-related increase in NMDA receptor binding in the left IMHV is related to memory rather than to acquisition.…”

Section: P Proceedings Of the Physiological Societymentioning

confidence: 52%

“…In domestic chicks a restricted region of the forebrain, the intermediate and medial part of the hyperstriatum ventrale (IMHV), is crucial for imprinting, and may be a site of information storage (see Horn, 1985). Exposure to an imprinting stimulus leads to (i) an increase in the mean length of postsynaptic density profiles of axospinous synapses (Horn et al 1985) and (ii) an increase in NMDA receptor binding (McCabe & Horn, 1988), both changes occurring in the left but not the right IMHV. The changes in NMDAsensitive binding were measured approximately 8 h after training.…”

Section: P Proceedings Of the Physiological Societymentioning

confidence: 99%

“…Chicks were either trained or dark-reared as previously described (McCabe & Horn, 1988) and killed up to 8-5 h after training. The left and right IMHVs were removed and frozen, membranes prepared and NMDA-sensitive binding of L-[3H]glutamate measured without knowledge of the chicks' experimental history or the side of the brain from which the tissue was taken.…”

Section: P Proceedings Of the Physiological Societymentioning

confidence: 99%

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Proceedings of the Physiological Society, 15‐16 December 1989, King's College London Meeting: Communications

1990

The Journal of Physiology

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It has been known for some time that it is possible to generate smooth eye movements in response to the discontinuous target motion which is produced when a moving target is briefly illuminated at intermittent intervals (Morgan & Turnbull, 1978). In an attempt to establish the mechanism of eye-movement control involved in this type of response we have examined the effects of varying the inter-pulse interval (PI) and pulse duration (PD) on the magnitude of the induced eye velocity for a number of different motion stimuli.Subjects were seated in front of a semicircular screen (radius 2 m) and viewed a moving visual target projected via a motor-driven mirror. Eye movements were recorded by an infra-red limbus tracking technique. An electromechanical shutter was used to control the duration of target exposure. Eight subjects took part in the experiments, which were conducted with the approval of the local ethical committee. In two initial experiments the target motion was a pseudo-random waveform composed of two sinusoids of frequency 0411 and 0 19 Hz, each with a peak velocity of 18 deg/s. When PI was held constant at 640 ms the ratio of the slow component eye velocity to target velocity (gain) progressively decreased from a mean of 0-80 when PD was 120 ms to a value of 0 50 when PD was 20 ms. When the pulse duration was less than 20 ms there was no apparent motion of the target within each exposure period and no further decline of eye velocity gain, indicating that the response was almost certainly evoked by the sequential changes in target position rather than by instantaneous target velocity. To examine the effect of inter-pulse interval on this response, PD was held constant at 10 ms whilst PI was varied. There was then a progressive decline in eye-velocity gain from 0-91 to 0-25 as PI was increased from 40 to 960 ms. In a third experiment the target motion was composed of a series of shortduration (320 ms) constant velocity (16 deg/s) ramps separated by blank intervals of 0-5-2 s. During the ramp motion the target was exposed for a duration of 10 ms at pulse intervals of 40, 80, 160 or 320 ms (i.e. 9, 5, 3 or 2 pulses/ramp). In response to each series of pulses eye velocity reached a peak which increased from 4-9 to 18-6 deg/s as PI decreased from 320 to 40 ms. In the interval between ramps eye velocity decayed with a time constant of 0-5-2 s, so that when this interval was decreased from 2 to 0 5 s, mean eye velocity increased as a result of the summation of these transient responses.The results indicate that each change of target position forms a sufficient stimulus to elicit a low-velocity (usually < 4 deg/s) smooth eye movement, although this may be augmented if the pulse duration is more than 20 ms. Because of the relatively slow decay of the transient oculomotor response to each pulse, eye velocity can be built up as a result of temporal summation to reach much higher levels as the interval between pulses is decreased below 1 s.

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Learning and memory: regional changes in N-methyl-D-aspartate receptors in the chick brain after imprinting.

Cited by 285 publications

References 34 publications

Localization of dopamine D1 receptors and dopaminoceptive neurons in the chick forebrain

Localization of dopamine D1 receptors and dopaminoceptive neurons in the chick forebrain

Allometric Comparison of the Brain and Brain Structures in the White Crested Polish Chicken with Uncrested Domestic Chicken Breeds

Proceedings of the Physiological Society, 15‐16 December 1989, King's College London Meeting: Communications

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