Learning by counting blood platelets in population studies: survey and perspective a long way after Bizzozero

Izzi, Benedetta; Bonaccio, Marialaura; Gaetano, Giovanni de; Cerletti, Chiara

doi:10.1111/jth.14202

Cited by 16 publications

(13 citation statements)

References 69 publications

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“…It is known that platelet counts are determined by several factors and decline with age, and that women have higher platelet counts than men [ 16 , 51 , 59 , 60 , 61 , 62 , 63 , 64 ]. For every 10 years, Santimone et al reported a sex-adjusted decline of 10 × 10 9 /L [ 65 ].…”

Section: Discussionmentioning

confidence: 99%

Reference Intervals for Platelet Counts in the Elderly: Results from the Prospective SENIORLAB Study

Hermann

Risch

Grebhardt

et al. 2020

JCM

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Currently, age- and sex-independent reference limits (RLs) are frequently used to interpret platelet counts in seniors. We aimed to define and validate reference intervals (RIs) for platelet counts within the framework of the prospective SENIORLAB study. Subjectively healthy Swiss individuals aged 60 years and older were prospectively included and followed for morbidity and mortality. Participants who had circumstances known to affect platelet counts were excluded. The obtained RIs were validated with indirect statistical methods. Frequencies of abnormal platelet counts in a population-based setting, including 41.5% of the entire age-specific population of the Principality of Liechtenstein, were compared by using age- and sex-independent RIs and the RLs obtained in the present study. For males (n = 542), 95% RIs for platelet counts were defined as follows: 150–300 × 109/L (60–69 years); 130–300 × 109/L (70–79 years); and 120–300 × 109/L (80 years and above). For females (n = 661), the consolidated age-independent 95% RI was 165–355 × 109/L. These RI values were validated by indirect RI determination of 51,687 (30,392 female/21,295 male) patients of the same age. Age- and sex-independent RIs exhibited imbalanced frequencies of abnormal platelet counts between the two sexes, which were corrected by introducing age- and sex-specific RLs. In conclusion, females have higher platelet counts than males. Whereas the upper RL for males remains constant, the lower RL decreases with age. We propose to abandon the practice of employing sex- and age-independent RL for platelet counts in the elderly.

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Section: Discussionmentioning

confidence: 99%

Reference Intervals for Platelet Counts in the Elderly: Results from the Prospective SENIORLAB Study

Hermann

Risch

Grebhardt

et al. 2020

JCM

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“…Platelet indices are extensively used as diagnostic and prognostic markers in several human pathological conditions. In particular, platelet count (Plt) and mean platelet volume (MPV) are assessed in clinical and population studies, often combined, as markers of platelet function [1]. In addition to the measurement of MPV, optical hematocytometry counters and automated measurements of impedance have allowed definition of the platelet distribution width (PDW), which is a volume parameter, measured as the difference between the highest and the lowest platelet volume, at 20% relative height in the platelet-size distribution histogram [2].…”

Section: Introductionmentioning

confidence: 99%

Platelet Distribution Width Is Associated with P-Selectin Dependent Platelet Function: Results from the Moli-Family Cohort Study

Izzi

Gialluisi

Gianfagna

et al. 2021

Cells

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Defined as an index of platelet size heterogeneity, the platelet distribution width (PDW) is still a poorly characterized marker of platelet function in (sub)clinical disease. We presently validated PDW as a marker of P-selectin dependent platelet activation in the Moli-family cohort. Platelet-bound P-selectin and platelet/leukocyte mixed aggregates were measured by flow cytometry in freshly collected venous blood, both before and after in vitro platelet activation, and coagulation time was assessed in unstimulated and LPS- or TNFα-stimulated whole blood. Closure Times (CT) were measured in a Platelet Function Analyzer (PFA)-100. Multivariable linear mixed effect regression models (with age, sex and platelet count as fixed and family structure as random effect) revealed PDW to be negatively associated with platelet P-selectin, platelet/leukocyte aggregates and von Willebrand factor (VWF), and positively with PFA-100 CT, and LPS- and TNF-α-stimulated coagulation times. With the exception of VWF, all relationships were sex-independent. In contrast, no association was found between mean platelet volume (MPV) and these variables. PDW seems a simple, useful marker of ex vivo and in vitro P-selectin dependent platelet activation. Investigations of larger cohorts will define the usefulness of PDW as a risk predictor of thrombo-inflammatory conditions where activated platelets play a contributing role.

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“…In addition to adhering to a self-management regimen, current literature suggests there are many determinants of self-management adherence. Evidence suggests that social resources, such as support from family, friends, and formal/informal support groups, can improve self-management adherence across chronic conditions (Dwarswaard, Bakker, van Staa, & Boeije, 2016; McDonald, Slavin, Pitts, & Elliott, 2015; Taylor et al, 2014). Higher levels of social resources, specifically social capital, has shown to improve medication adherence and quality of life in PLWH (Webel, Sattar, Schreiner, & Phillips, 2016).…”

Section: Introductionmentioning

confidence: 99%

A descriptive, cross-sectional study examining treatment burden in people living with HIV

Schreiner

Perazzo

Currie

et al. 2019

Applied Nursing Research

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Aim: (1) describe the percentage of people living with HIV (PLWH) experiencing high levels of treatment burden who are at risk for self-management non-adherence, and (2) examine the relationship between known antecedent correlates (the number of chronic conditions, social capital, and age) of self-management and treatment burden while controlling for sample socio-demographics. Background: Chronic condition self-management is key to maintaining optimal health in the aging population of PLWH. Despite the efforts of providers, patients, and caregivers, self-management non-adherence is still a factor contributing to poor chronic condition self-management and subsequent poor health outcomes. Recent research has identified treatment burden as a risk factor of poor chronic disease self-management adherence. Method: Cross-sectional, secondary analysis of a sub-sample of 103 community dwelling, men and women diagnosed with HIV/AIDS derived from a larger parent study examining physical activity patterns in PLWH. Results: Participants reported an overall low level of treatment burden (M = 22.84; SD = 24.57), although 16% (n = 16) of the sample indicated experiencing high treatment burden. The number of chronic conditions (r = 0.25; p ≤ .01) and social capital (r = −0.19; p = .03) were significantly correlated with treatment burden. Multivariate analysis testing known antecedent correlates of treatment burden was statistically significant (p < .05), but only explained 8% of treatment burden’s variance. Conclusion: Findings have implications for nursing care of PLWH demonstrating a subset of PLWH experience high treatment burden related to chronic condition self-management. Findings also identify characteristics of PLWH who may be at high risk for treatment burden and subsequent self-management non-adherence.

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Learning by counting blood platelets in population studies: survey and perspective a long way after Bizzozero

Cited by 16 publications

References 69 publications

Reference Intervals for Platelet Counts in the Elderly: Results from the Prospective SENIORLAB Study

Reference Intervals for Platelet Counts in the Elderly: Results from the Prospective SENIORLAB Study

Platelet Distribution Width Is Associated with P-Selectin Dependent Platelet Function: Results from the Moli-Family Cohort Study

A descriptive, cross-sectional study examining treatment burden in people living with HIV

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