Learning skills and academic performance in children and adolescents with absence epilepsy

MiR‐181b inhibits P38/JNK signaling pathway to attenuate autophagy and apoptosis in juvenile rats with kainic acid‐induced epilepsy via targeting TLR4

“…To further explore the interaction between miR‐181b and TLR4, as well as its underlying mechanism in epilepsy, we gave an injection of miR‐181b agomir or TAK‐242 (TLR4 inhibitor) to KA‐induced epileptic juvenile rats, and our findings demonstrated that the spatial memory abilities of rats, as a kind of advanced neural activity of brain, which was an important element of both cognition and intelligence structure, whereas many epileptic patients have severe cognitive impairment, were significantly improved . Besides, miR‐181b and TAK‐242 in this work could significantly inhibit the cell apoptosis in hippocampus tissue of KA‐induced epileptic rats, with down‐regulation of Bax and cleaved caspases‐3 expressions but upregulation of Bcl‐2.…”

“…,37 Besides, miR-181b and TAK-242 in this work could significantly inhibit the cell apoptosis in hippocampus tissue of KA-induced epileptic rats, with down-regulation of Bax and cleaved caspases-3 expressions but upregulation of Bcl-2. As we know, SE seizure may result in morphological changes of hippocampal neurons, such as cellular swelling, rupture, karyopyknosis or karyolysis, apoptosis, and autophagic corpuscle formation 38.…”

Impact of a multicomponent physical activity intervention on cognitive performance: The MOVI‐KIDS study

“…Assessed using the Battery of General and Differential Aptitudes for schoolchildren aged 6‐8 years (BADyG E1). This battery has shown an excellent reliability (Cronbach's α = 0.92 to general intelligence), and strong predictive validity between general intelligence and scores in Language and Mathematics ( r = 0.609; P = 0.001; r = 0.687; P = 0.001, respectively) and is the most commonly used battery in schools and research studies in Spain . This tool consisted of 162 items grouped in different tests that allow assessing some specific cognitive dimensions: logical reasoning (ability to establish analogy relations between concepts, flexibility to perform numerical‐verbal problems, and inductive reasoning), the verbal factor (ability to discover relationships between concepts and verbal comprehension), the numerical factor (ability to solve numerical problems safely and quickly), and the spatial factor (ability to make spatial turns with geometric figures and their inductive reasoning); and global computation of general intelligence (calculated as the sum of the four specific dimensions).…”

Anxiety and school avoidance in an 8-year-old child with epilepsy

“…Even if able to go to school, many children are aware that they have disrupted attention for some reason that is unpredictable in nature and they may be on some level worried about missing important details either academically or socially. Children with epilepsy commonly have academic problems [1] , [2] , [3] , [4] , [5] , [6] and learning disabilities [7] , [8] . Even though absence seizures are brief in duration, the consequences of disrupted attention may have effects well beyond the time span of the active seizure.…”