Leaves of Cleome amblyocarpa Barr. And Murb. And Cleome arabica L.: Assessment of nutritional composition and chemical profile (LC-ESI-MS/MS), anti-inflammatory and analgesic effects of their extracts

Khlifi, Aida; Pecio, Łukasz; Lobo, Joana C.; Melo, Diana; Ayache, Siwar Ben; Flamini, Guido; Oliveira, M.B.P.P.; Oleszek, Wiesław; Achour, Lotfi

doi:10.1016/j.jep.2020.113739

Cited by 12 publications

(7 citation statements)

References 39 publications

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“…The fresh plant extract of Cleome amblyocarpa was prepared following the method described earlier by Khlifi et al (2021) with slight modifications. Figure (1A) shows wild fresh plant material collected from Al-Arish region, North Sinai, Egypt, and was identified as Cleome amblyocarpa according to (Aparadh et al, 2012 andRassouli et al, 2014).…”

Section: Collection and Preparation Of Cleome Amblyocarpa Extractmentioning

confidence: 99%

“…It is widely growing in desert sandy habitats of Sinai, Egypt, and many parts of North Africa (Kamel et al, 2010). This herb possesses different biological activities, containing anti-inflammatory, anti-COVID-19, genotoxicity, antidiabetic, antioxidant, and antimicrobial effects (Takhi et al, 2011;Edziri et al, 2013;Zaki et al, 2020;Khlifi et al, 2021 andSeglab et al, 2021;).…”

Section: Introductionmentioning

confidence: 99%

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Effect of Green Biosynthesized Silver Nanoparticles Using Cleome amblyocarpa on Controlling Chickpea Wilt

Elsharawy

Ibrahim

Mossa

2023

Egyptian Journal of Phytopathology

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The antifungal activity of green synthesized silver nanoparticles (AgNPs) from Cleome amblyocarpa was investigated against the phytopathogenic fungus Fusarium oxysporum (MW485609) the cause of chickpea wilt. Experimental results showed that the growth of F. oxysporum started to reach 50 % inhibition at 80 𝜇g/mL of AgNPs and also with 150 𝜇g/mL plant extract. The highest reduction % on the mycelial growth was 60.4 ± 0.00 and 67.4±1.16mm with plant extract and green synthesized nanoparticles, respectively. Data also revealed that the most effective concentration of green AgNPs solution was, 200 µl/mL, which showed 5.18 % and 9.79 % early and late wilt incidence. On the other hand, early and late wilt incidence recorded 11.24 % and 16 % due to plant extract. Meanwhile, plant survival rates were 85.03 % and 72.76 %, respectively, whereas the untreated control plants recorded only 4.85 % survivals. Images proved that the green synthesized silver nanoparticles affected the morphology of fungal hyphae grown on media supplemented with (AgNPs) solution and nanoparticles appeared in fungal cell walls compared with the effect of plant extract and with fungal hypha of control plates. Moreover, observations with TEM and SEM revealed that synthesized nanoparticles damaged fungal hyphae, causing the deformation of cell membranes and inhibition of the normal budding process. The solution of AgNPs illustrates good stability at -19.8 mV at an area of 100 %, a width of 6.75 mV. The size of AgNPs ranged from 6.06 to 40.9 nm; Mean = 20.088 nm, Dev (rms) = 7.2 nm. This research demonstrates that (AgNPs) can be employed as a safe and environmentally acceptable alternative in controlling pathogenic fungi, and limits dependence on fungicides and avoids the development of fungicide-resistant phytopathogenic generations. The green synthesis of nanoparticles with the help of C. amblyocarpa was considered a practicable and environmentally friendly way.

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Section: Collection and Preparation Of Cleome Amblyocarpa Extractmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Green Biosynthesized Silver Nanoparticles Using Cleome amblyocarpa on Controlling Chickpea Wilt

Elsharawy

Ibrahim

Mossa

2023

Egyptian Journal of Phytopathology

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“…The prevalence of T2DM is alarmingly rising worldwide with increased mortality. [1][2][3] The development of T2DM is influenced by both genetic and environmental factors and certain ecological factors, like calorie consumption, food composition, atmospheric air pollution, and lack of physical activity, play a prominent role in the disease's ongoing rise in prevalence. [4][5][6] T2DM is also associated with many problems, such as retinopathy, foot lesions, renal disease, atherosclerosis, coronary artery disease, and atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Profiling and Assessment of Antidiabetic Activity of Curcuma Angustifolia Rhizome Methanolic Extract: An In Vitro and In Silico Analysis

Kavya,

Gayathri

2024

Chemistry & Biodiversity

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Curcuma angustifolia Roxb. is a plant with medicinal potential, traditionally used to treat different diseases. The present study was aimed to determine the antidiabetic activity of C. angustifolia rhizome in vitro and in silico. The methanolic extract of C. angustifolia rhizome was analysed by FTIR and GC‐MS to determine the phytochemicals present. The antidiabetic potential of the extract was evaluated by different assays in vitro. The extract inhibited both α‐amylase and α‐glucosidase enzymes and the glucose diffusion through the dialysis membrane in a concentration‐dependent manner with IC50 values of 530.39±0.09, 293.75±0.11, and 551.74±0.3 µg/ml respectively. The methanolic extract also improved yeast cell’s ability to take up glucose across plasma membranes and the adsorption of glucose. The findings were supported by molecular docking studies. The results showed that the methanol extract of C. angustifolia rhizome has significant antidiabetic activity and thus can be also studied to isolate the potential compound with antidiabetic activities.

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“…With the current changes in the lifestyle of developing countries, a group of serious diseases emerged due to excessive oxidative stress including neurodegenerative disorders, cancer, and metabolic and cardiovascular diseases. Many enzymes including AChE and BChE participate in the development and progression of these diseases [9]. Therefore, it is critical to seek out new and safe antioxidants, as well as plant-derived AChE and BChE inhibitors with better outcomes.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of In Vitro and In Silico Anti-Alzheimer Potential of Nonpolar Extracts and Essential Oil from Mentha piperita

Srief

Bani

Mokrani

et al. 2023

Foods

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The anticholinesterase and antioxidant activities with chemical composition and molecular docking of essential oil and nonpolar extracts of Mentha piperita were evaluated using enzymatic and chemical methods. Molecular docking tools were used to explain the interaction of the major chemical constituents with the enzymes. GC/MS analyses revealed that the main compounds in M. piperita essential oil were l-menthone (43.601%) followed by pulegone (21.610%), linolenic acid (25.628%), and l-menthone (10.957%), representing the major compounds of the petroleum ether extract. Imidazoquinoline (7.767%) and 17-N-acetyl-oroidine (5.363%) were the major constituents of the chloroform extract. Linolenic acid (19.397%) and l-menthone (6.336%) were the most abundant compounds in the hexane extract. The M. piperita essential oil and nonpolar extracts showed moderate antioxidant activity. The essential oil showed the most promising anticholinesterase activity with IC50 = 10.66 ± 0.12 µg/mL and IC50 = 16.33 ± 0.03 µg/mL against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), respectively, close to galantamine in AChE and more active in BChE, followed by the interesting activity in the petroleum ether extract with IC50 = 23.42 ± 3.06 µg/mL in AChE and IC50 = 62.00 ± 3.22 µg/mL in BChE. The docking experiments showed that among the seven major identified compounds, N-acetyl-17-oroidine showed the highest binding score (63.01 in AChE and 63.68 in BChE). This compound was found to bind the catalytic and peripheral sites, resulting in more potent inhibitory activity than galantamine, which only binds to the catalytic site. These findings suggested the possible use of M. piperita essential oil and nonpolar extracts as a potential source of alternative natural anti-Alzheimer compounds.

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Leaves of Cleome amblyocarpa Barr. And Murb. And Cleome arabica L.: Assessment of nutritional composition and chemical profile (LC-ESI-MS/MS), anti-inflammatory and analgesic effects of their extracts

Cited by 12 publications

References 39 publications

Effect of Green Biosynthesized Silver Nanoparticles Using Cleome amblyocarpa on Controlling Chickpea Wilt

Effect of Green Biosynthesized Silver Nanoparticles Using Cleome amblyocarpa on Controlling Chickpea Wilt

Phytochemical Profiling and Assessment of Antidiabetic Activity of Curcuma Angustifolia Rhizome Methanolic Extract: An In Vitro and In Silico Analysis

Evaluation of In Vitro and In Silico Anti-Alzheimer Potential of Nonpolar Extracts and Essential Oil from Mentha piperita

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