Leaving previously implanted central venous catheters (ports) in place does not increase morbidity in patients undergoing autologous peripheral stem cell transplantation

Miceli, Marisa H.; Lei, Dong; Coria, P.; Vila, Andrea; Estrada, Sarah; Garcia-Damiano, M. C.; Martínez-Rolón, Juliana; Milone, Giuseppe; Dignani, María Cecilia

doi:10.1038/sj.bmt.1705018

Cited by 1 publication

(1 citation statement)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are some studies, mostly performed in children, studying complications of a single catheter used for both stem-cell apheresis and high-dose chemotherapy, but comparative studies are not available. [18][19][20][21][22][23] Most of these studies indicate that use of a single catheter is safe and effective, but sometimes as few as 31% of patients are able to complete the whole procedure with only one catheter. 18 In our study the catheter for dual purpose had to be removed before the end of the procedure because of infectious complications in 37.1% of patients.…”

Section: Discussionmentioning

confidence: 99%

Factors influencing catheter-related infections in the Dutch multicenter study on high-dose chemotherapy followed by peripheral SCT in high-risk breast cancer patients

Nieboer

Vries

Mulder

et al. 2008

Bone Marrow Transplant

View full text Add to dashboard Cite

Neutropenia following high-dose chemotherapy leads to a high incidence of infectious complications, of which central venous catheter-related infections predominate. Catheter-related infections and associated risk factors in 392 patients participating in a randomized adjuvant breast cancer trial and assigned to receive high-dose chemotherapy and peripheral stem-cell reinfusion were evaluated. Median catheter dwell time was 25 days (range 1-141). Catheter-related infections were seen in 28.3% of patients (11 infections per 1000 catheter-days). Coagulase-negative staphylococci were found in 104 of 186 positive blood cultures (56%). No systemic fungal infections occurred. Cox regression analysis showed that duration of neutropenia 410 days (P ¼ 0.04), using the catheter for both stem-cell apheresis and high-dose chemotherapy (P ¼ o0.01), and use of total parenteral nutrition (TPN, P ¼ 0.04) were predictive for catheter-related infections. In conclusion, a high incidence of catheter-related infections after high-dose chemotherapy was seen related to duration of neutropenia, use of the catheter for both stem-cell apheresis and high-dose chemotherapy, and use of TPN. Selective use and choice of catheters could lead to a substantial reduction of catheter-related infectious complications.

show abstract