Lebermetastasen kolorektaler Karzinome

Abstract

Liver metastases are the most common cause of death in colorectal cancer patients. Nowadays, complete resection is considered to be the only curative treatment but only approximately 25% of patients are suitable candidates for surgery; therefore, many different interventional oncology techniques have been developed in recent years for the treatment of secondary liver metastases. The aim of interventional oncological procedures is either to provide a potentially curative treatment option for locally limited metastases with local ablative techniques, to enable nonresectable tumors to become accessible to surgical or local ablative techniques using transarterial procedures or to achieve improved survival in a palliative setting. These interventional therapies include transarterial approaches, such as chemoembolization and radioembolization as well as a multitude of different ablative techniques, such as radiofrequency and microwave ablation as well as irreversible electroporation (IRE). This article describes the indications for the various procedures and the clinical results of each of these techniques are reviewed based on the currently available literature.

Supramolecular Photothermal Nanomedicine Mediated Distant Tumor Inhibition via PD-1 and TIM-3 Blockage

“…In clinical practice, the clearance of the primary tumor can be realized through surgical removal, thermal-related ablation, and radiation (Chu and Dupuy, 2014;Lee et al, 2014;Chen et al, 2016a;Yang et al, 2017), while the metastatic site often escapes the locoregional destruction due to the limitation of tumor detection or accessibility. Unsolved metastasis is one of the major causes of tumor recurrence and treatment failure in cancer patients (Mahnken et al, 2013;Sag et al, 2016;Hoffmann, 2017). Compared to traditional surgical removal, ablation and radiation not only help the eradication of the primary tumor but also serve as effective ways to promote tumor-related immune responses, which is also known as the transformation from cold tumor to hot tumor (Finkelstein et al, 2011;Mehta et al, 2016;Tang et al, 2016).…”

Knockdown of miR-27a sensitizes colorectal cancer stem cells to TRAIL by promoting the formation of Apaf-1-caspase-9 complex

“…Colorectal cancer represents the third most common cancer around the world [ 1 ]. Because of the liver metastases in early stage, colorectal cancer is realized as the “leading killer”, which has become a serious threat to human life and health [ 2 , 3 ]. For treatment of colorectal cancer, chemotherapy is efficient initially.…”