Lecithin: Cholesterol Acyltransferase Activity,
HDL-Cholesterol and Apolipoprotein A in Serum of Patients
Undergoing Chronic Haemodialysis

Jung, Klaus; Neumann, Regina; Precht, K; Nugel, E; Scholz, D

doi:10.1159/000459263

Cited by 20 publications

(4 citation statements)

References 4 publications

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“…Our results are in conflict with those of Jung ct al. [11] who found no improvement in LCAT activity after hemodialysis. It remains to be seen if this discrepancy is due to differences in methodology, patient selection or treatment modality.…”

Section: Discussionmentioning

confidence: 96%

Lecithin: Cholesterol Acyltransferase Activity in Dialyzed and Undialyzed Chronic Uremic Patients

Bories

Subbaiah²,

Bagdade

1982

Nephron

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Lecithin cholesterol acyltransferase (LCAT) and lysolecithin acyltransferase (LAT) activities in plasma were significantly lower in undialyzed than in dialyzed uremic patients and controls. Both LCAT and LAT activities were normal in the maintenance dialysis group. The free/total cholesterol ratio was significantly increased in the undialyzed patients only. This ratio and LCAT were inversely related in the dialyzed group, unrelated in the undialyzed patients, and positively correlated in controls. Unlike non-uremic populations with hypertriglyceridemia in which LCAT is increased, no correlation was found between plasma triglyceride and LCAT in the uremic population studied. Our results show that both LCAT and LAT activities are reduced in undialyzed chronic uremic patients but are not significantly different from control levels in patients treated with chronic hemodialysis. These results indicate that the changes in LCAT activity contrast with those described in lipoprotein composition and metabolism which do not appear to be affected by chronic dialysis therapy.

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Section: Discussionmentioning

confidence: 96%

Lecithin: Cholesterol Acyltransferase Activity in Dialyzed and Undialyzed Chronic Uremic Patients

Bories

Subbaiah²,

Bagdade

1982

Nephron

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“…Since the HDL-cholesterol concentration is simultaneously decreased in these patients [4,6,11], there is an impaired HDL-LCAT sys tem in haemodialysed patients which could lead to cholesterol accumulation in cells as observed in human LCAT deficiency states. Therefore, it is of particular interest that our present study demonstrates a normal LCAT activity in renal transplant recipients.…”

Section: Discussionmentioning

confidence: 99%

“…All samples were run in duplicate and the activities are given as the means of these determina Serum cholesterol concentration rises in the majority of patients after kidney trans plantation [2], However, details on the dis turbed cholesterol metabolism in this patient group are largely unknown until now. Since the enzyme lecithinxholesterol acyltransfer ase (LCAT, EC 2.3.1.43) is of considerable importance in cholesterol metabolism [14], we measured, in addition to HDL-cholester ol, HDL-triglyceride and apolipoprotein A, the activity of this enzyme in patients with kidney transplants to pursue our studies on the behaviour of this enzyme in haemodialysed patients [11].…”

Section: Methodsmentioning

confidence: 99%

LecithiniCholesterol Acyltransferase Activity and HDL Composition in Serum of Patients with Kidney Transplants

Jung¹,

Neumann²,

Scholz³

et al. 1983

Enzyme

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In comparison with a control group, lecithinxholesterol acyltransferase activities and HDL-cholesterol concentrations in serum of patients with kidney transplants were unchanged, while apolipoprotein A and HDL-triglyceride concentrations were increased. This constellation shows that the cholesterol metabolism in patients with kidney transplants differs from that of patients undergoing chronic haemodialysis.

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“…One such enzyme is lecithin-cholesterol acyltransferase (LCAT), deficiency of which has been shown to occur in renal disease. [19][20][21][22][23][24] In the present study, we reassessed plasma lipids and lipoproteins, including both free cholesterol and CE as well as phospholipids, in patients with end-stage renal failure drawn from the multiracial population of the United Arab Emirates. The results suggest that a decreased concentration of CE relative to total cholesterol occurs commonly in renal failure and is associated with other lipid changes, while patients with high levels of cholesteryl esters show essentially normal levels of other lipids and lipoproteins.…”

mentioning

confidence: 99%

Levels of Cholesteryl Esters and Other Lipids in the Plasma of Patients with End-Stage Renal Failure

Gillett

Obineche

Lakhani

et al. 2001

Annals of Saudi Medicine

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Background:The importance of plasma lipid abnormalities in chronic renal failure (CRF) is well recognized, but surprisingly little attention has been given to the study of some plasma lipid fractions, including cholesteryl esters (CE) and phospholipids, which might be expected to be important factors in the pathogenesis of the disease. Materials and Methods: Fasting blood samples were taken from 25 control subjects and 53 CRF patients (29 predialysis and 24 on hemodialysis). Samples were analyzed for urea nitrogen, creatinine, triacylglycerols, total and individual phospholipids, total and free cholesterol, as well as cholesterol bound to very low-, low-and high-density lipoproteins (VLDL, LDL and HDL). Plasma CE was calculated and expressed as a percentage of total cholesterol. Results: Over half of the patients had CE levels more than two standard deviations below the control value. In this subgroup of low CE patients, total, LDL-and HDL-cholesterol levels were also significantly lower than for controls, while levels of phosphatidylcholine and lysophosphatidylcholine were decreased and increased, respectively. In patients with high CE, no significant lipid abnormalities were observed. Conclusion: In this study, CE was an excellent marker for lipid disturbances-if CE was high, then the other lipid fractions were normal, but if CE was low, most other lipid fractions were abnormal. The changes noted appear to be consequences of or related to deficiency of the plasma enzyme lecithin-cholesterol acyltransferase. Ann Saudi Med 2001;21(5-6):283-286.

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Lecithin: Cholesterol Acyltransferase Activity, HDL-Cholesterol and Apolipoprotein A in Serum of Patients Undergoing Chronic Haemodialysis

Cited by 20 publications

References 4 publications

Lecithin: Cholesterol Acyltransferase Activity in Dialyzed and Undialyzed Chronic Uremic Patients

Lecithin: Cholesterol Acyltransferase Activity in Dialyzed and Undialyzed Chronic Uremic Patients

LecithiniCholesterol Acyltransferase Activity and HDL Composition in Serum of Patients with Kidney Transplants

Levels of Cholesteryl Esters and Other Lipids in the Plasma of Patients with End-Stage Renal Failure

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