Lecithinized Superoxide Dismutase Suppresses Free Radical Substrates During the Early Phase of Burn Care in Rats

Koizumi, Takeo; Goto, Hideaki; Tanaka, Hideharu; Yamaguchi, Yoshihiro; Shimazaki, Shuji

doi:10.1097/bcr.0b013e318198e764

Cited by 6 publications

(6 citation statements)

References 40 publications

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“…All the procedure was done by the same person to minimize the bias of differences in the force the person applies. The reliability of this method in the production of full thickness burns has previously been validated by Koizumi et al [ 24 ].…”

Section: Methodsmentioning

confidence: 99%

Pistacia atlanticaResin Has a Dose-Dependent Effect on Angiogenesis and Skin Burn Wound Healing in Rat

Haghdoost

Mahdavi

Zandifar

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Objectives. The aim of the present study was to evaluate the effect of Pistacia atlantica resin extract on the rat skin burn wound healing. Methods. Thirty-two Wistar rats were divided into four groups and treated by vehicle, 5%, 10%, and 20% concentration of Pistacia atlantica resin extract for 14 days (G1, G2, G3, and G4, resp.). The efficacy of treatment was assessed based on reduction of burn wound size and histological and molecular characteristics. Results. α-Pinene (46.57%) was the main content of essential oil of resin. There were no statistically significant differences between groups according to wound size analysis. The mean histological wound healing scores were not statistically different. Capillary counts of G2 and G3 were significantly higher than those of the G1 (P = 0.042 and 0.032, resp.). NO concentration in wound fluids on the 5th day of study was not significantly different between groups (P = 0.468). But bFGF concentration in G2 and G3 and PDGF concentration in G3 were significantly higher in comparison to G1 (P = 0.043, 0.017, and 0.019, resp.). Conclusion. Our results revealed that Pistacia atlantica resin extract has a concentration-dependent effect on the healing of burn wounds after 14 days of treatment by increasing the concentration of bFGF and PDGF and also through improving the angiogenesis.

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Section: Methodsmentioning

confidence: 99%

Pistacia atlanticaResin Has a Dose-Dependent Effect on Angiogenesis and Skin Burn Wound Healing in Rat

Haghdoost

Mahdavi

Zandifar

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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“…showed that severe burn damage cause promotion of free radicals which in turn result in vasodilatation and SOD can act as a protective factor against vasodilatation. 26 Here we proved that P. atlantica resin oil significantly compared with burn control group elevated SOD levels.…”

Section: Discussionmentioning

confidence: 51%

Effect of Pistacia Atlantica Resin Oil on Anti-Oxidant, Hydroxyprolin and VEGF Changes in Experimentally-Induced Skin Burn in Rat

Shahouzehi

Sepehri

Sadeghiyan

et al. 2018

wjps

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BACKGROUNDSevere burn damage and its consequences are life threatening which can complicate patients’ health. Medicinal and traditional plants are considered as safe, natural and inexpensive source of treatment for wide variety of diseases. This study assessed beneficial effect of Pistacia atlantica oil on rats burn wound healing and its potential effects on malondialdehyde (MDA), vasculoendothelial growth factor (VEGF), hydroxyprolin and antioxidant status in wound area.METHODSThirty male rats weighing 200±10 g were randomly divided into three groups (n=10) as follows. Group 1 underwent just burn injury, Group 2 underwent burn injury and received 150 mg/kg/day P. atlantica oil topically, and Group 3 underwent burn injury and received 150 mg/kg/day sulfadiazine cream topically. At the end of the study (day 14), wounded areas were measured and then skin in the burn damage were dissected and anti-oxidative parameter, MDA, VEGF and hydroxyprolin were evaluated. RESULTS P. Atlantica oil significantly increased antioxidant defense, VEGF, hydroxyprolin and reduced MDA levels. It could remarkably reduce wound size compared to burn control group. P. Atlantica oil showed more beneficial effects than sulfadiazine.CONCLUSION P. atlantica resin oil could be considered as a new therapeutic agent for treatment of injuries.

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“…MDA is oneterminal metabolite of unsaturated fatty acids peroxidized by attacks from free radicals and is considered to be an index of the level of OFR, thiobarbituric acid method is one of the commonly used methods for the detection of MDA 3. SOD is an important reducing agent and antioxidant involved in maintaining the cellular oxidation reduction balance, which can also scavenge free radicals produced by oxidative stress, and may be useful as an antioxidant and as a cytoprotective agent 18. Combined detection of MDA and SOD can detect OFR injury more effectively 19,20.…”

Section: Discussionmentioning

confidence: 99%

<p>Protective effects of tiopronin against oxidative stress in severely burned patients</p>

Qin

Chen

et al. 2019

DDDT

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Objective Tiopronin is an antioxidant. This study investigated the protective effect of tiopronin on oxidative stress in patients with severe burns. Method Patients aged between 16 and 65 years old with >30% body surface area burns admitted to our burn unit from July 2011 to September 2016 were randomly divided into 3 groups: group A treated with tiopronin (15 mg/kg. 24 hrs), group B with vitamin C (792 mg/kg. 24 hrs), the other group with standard treatment (group C). All 3 groups also received standard treatment. Blood superoxide dismutase (SOD), malondialdehyde (MDA), and the biochemical indexes of liver, kidney, and heart were determined before treatment and 24 and 48 hrs after treatment. Samples from 8 normal healthy adult volunteers were also measured. The resuscitation fluid volume requirement for the first 24 hrs was calculated for 3 groups. Results The serum levels of MDA and the biochemical indexes in severely burned patients were higher than those in healthy volunteers ( P <0.01). The serum SOD level of burn patients was lower ( P <0.01). After treatment, the levels of SOD increased, the levels of MDA decreased, and the biochemical indexes of heart, liver, and kidney improved; these changes were more obvious in group A and group B compared to group C ( P <0.05), and these changes were more obvious in group A compared to group B ( P <0.05) at 48 hrs after treatment. There is less resuscitation fluid volume requirement to maintain adequate stable hemodynamic and urine output in the first 24 hrs in group A and group B compared to group C ( P <0.05). Conclusion Treatment with tiopronin could exert protective effects against burn-induced oxidative tissue damage and multiple-organ dysfunction, and also could reduce the volume of required fluid resuscitation in severely burned patients.

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Lecithinized Superoxide Dismutase Suppresses Free Radical Substrates During the Early Phase of Burn Care in Rats

Cited by 6 publications

References 40 publications

Pistacia atlanticaResin Has a Dose-Dependent Effect on Angiogenesis and Skin Burn Wound Healing in Rat

Pistacia atlanticaResin Has a Dose-Dependent Effect on Angiogenesis and Skin Burn Wound Healing in Rat

Effect of Pistacia Atlantica Resin Oil on Anti-Oxidant, Hydroxyprolin and VEGF Changes in Experimentally-Induced Skin Burn in Rat

<p>Protective effects of tiopronin against oxidative stress in severely burned patients</p>

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