Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Plays an Important Role in Vascular Inflammation in Current Smokers

Serum sLOX-1 Levels Are Correlated with the Presence and Severity of Obstructive Sleep Apnea

“…Whether other mechanisms contribute to the increased LOX-1 expression is yet to be further investigated. Serum sLOX-1 levels are elevated in many inflammatory diseases (Hayashida et al, 2005;Lubrano et al, 2008;Yan et al, 2011;Takanabe-Mori et al, 2013). Its clinical importance is gradually increasing as a potential biomarker of various inflammatory diseases.…”

“…LOX-1 was mainly expressed by endothelial cells (ECs) and later found also to be inducibly expressed by vascular smooth muscle cells (VSMCs), macrophages, and platelets (Zhao et al, 2011). Recent studies have verified that LOX-1 activation is involved in the inflammatory process and inflammatory-related disorders (Hayashida et al, 2005;Lubrano et al, 2008;Yan et al, 2011;Takanabe-Mori et al, 2013).…”

Elevated Soluble Lectin-like oxidized LDL Receptor 1 (sLOX1) levels in sickle cell patients

“…Since sickle-cell patients were exposed to a chronic inflammatory disease, we evaluated hsCRP levels in sickle-cell patients and investigated whether there was a correlation between this inflammatory protein and sLOX1. Although hsCRP levels were significantly higher in sickle-cell patients compared to controls (table 1), but we found no positive correlation (Pearson correlation test = 0.62).This correlation was found in smokers [5], subjects suffering from Obstructive Sleep (OSA) [1]. A correlation between sLOX1 and hsCRP, troponin and CKmb was found in of patients with ACS.…”

“…To our knowledge, this study is the only one in our regions to have studied this receptor in sickle-cell anemia, but a preliminary study carried out in our laboratory had found higher levels of LDL oxidized in sickle-cell patients [19]. In addition to diabetes and cardiovascular diseases other pathological conditions have been associated with LOX 1, including obesity [20] smoking [5] and various cardio-pulmonary diseases [21][22][23] Another protein implicated in cardiovascular risk is the high-sensitivity C-reactive protein (hs CRP) and the results of our research have shown that it plays an important role in the release of the soluble form of LOX1 [24]. Since sickle-cell patients were exposed to a chronic inflammatory disease, we evaluated hsCRP levels in sickle-cell patients and investigated whether there was a correlation between this inflammatory protein and sLOX1.…”

“…In addition to its role in atherosclerosis, LOX-1 also acts in the inflammatory process. Indeed, recent studies have shown that LOX-1 is involved in the activation of inflammatory processes and inflammation-related disorders [1][2][3][4][5]. Like most surface receptors, LOX-1 can be released in soluble form by proteolytic cleavage and this soluble form (sLOX-1) could be a serum marker in the monitoring of oxidative and/or inflammatory diseases such as sickle-cell disease.…”