Lectins and Blood Group Substances as “Tumor Markers”

Caselitz, J.

doi:10.1007/978-3-642-71356-9_11

Cited by 42 publications

(15 citation statements)

References 95 publications

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“…A high level of WGA, PNA and ConA binding, and a reduction in UEA binding, appears to correlate with high grade, invasive bladder cancers (Neal et al, 1987;Caselitz, 1987). However, the variation observed in the cell surface lectin binding profiles of the UCRU BL 17CL clones has not correlated with other characteristics of the clones studied in this report.…”

Section: Growth In Vivocontrasting

confidence: 59%

Clonal analysis of a bladder cancer cell line: an experimental model of tumour heterogeneity

Brown

Russell²,

Philips³

et al. 1990

Br J Cancer

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Summary The continuous cell line UCRU BL 17CL was derived from a human invasive bladder cancer and expresses elements of transitional, squamous and glandular differentiation. Nine clones of this line were established by limit dilution and have been extensively characterised. Only six of these clones grew subcutaneously in nude mice. Of these, three have exhibited local invasion, each in one of five implanted mice. Although all xenografts expressed transitional, squamous and glandular elements, different histological subtypes predominated within each clone. Only clones which grew in nude mice formed colonies in semi-solid medium, and each responded differently to the influence of medium that had been conditioned by the growth of UCRU BL 17CL, suggesting the possible secretion of a growth factor by these cells. The DNA content and lectin binding profiles of the clones also reflected the heterogeneity of the line. UCRU BL 17CL and the nine clones provide a unique model for the study of tumour heterogeneity, progression and differentiation, and the potential autocrine regulation of growth of bladder cancer.In human bladder cancer, and in many other cancer types,

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Section: Growth In Vivocontrasting

confidence: 59%

Clonal analysis of a bladder cancer cell line: an experimental model of tumour heterogeneity

Brown

Russell²,

Philips³

et al. 1990

Br J Cancer

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“…The structural complexity in carbohydrate structures, which reflects the large amount of information available for their interactions, makes these carbohydrate antigens ideal markers for various cellular processes (Gabius, 1988;Mandel et al, 1988;Glinsky, 1992). The most widely studied surface glycoproteins are blood group antigens, and the expression of these antigens shows profound alterations during various disease states, especially in malignancy (Caselitz, 1987;Dabelsteen et al, 1988Dabelsteen et al, , 1992). An important and convenient class of probes for the analysis of alterations in the expression of carbohydrates is the family of lectins (Lis and Sharon, 1986;Caselitz, 1987;Alroy et al, 1988;Walker, 1989).…”

Section: Glycoconjugates and Pathologymentioning

confidence: 99%

“…The most widely studied surface glycoproteins are blood group antigens, and the expression of these antigens shows profound alterations during various disease states, especially in malignancy (Caselitz, 1987;Dabelsteen et al, 1988Dabelsteen et al, , 1992). An important and convenient class of probes for the analysis of alterations in the expression of carbohydrates is the family of lectins (Lis and Sharon, 1986;Caselitz, 1987;Alroy et al, 1988;Walker, 1989). Until recently, only lectins of plant origin have been used extensively to study the sugar expression patterns in various types of cells and tissues.…”

Section: Glycoconjugates and Pathologymentioning

confidence: 99%

“…Most of the studies in lectin biology have been on their agglutination, immunomodulatory and cytotoxic properties (Liener et al, 1986;Gabius and Gabius, 1993;Vijayakumar et al, 1994) and are mostly confined to cancer biology, because significant alterations in the composition of cellular glycoconjugates have been shown more often in malignant conditions than in other disease states . Reviews and monographs on the use of lectins in histopathology are available and are recommended reading to get wider perspectives on lectin histochemistry (Liener et al, 1986;Caselitz, 1987;Damjanov, 1987;Alroy et al, 1988;Danguy et al, 1988;Gabius, 1988;Sharon and Lis, 1989;Walker, 1989;Gabius and Gabius, 1991;Vierbuchen, 1991;Spicer and Schulte, 1992;Gabius and Gabius, 1993;Danguy et al, 1994;Vijayakumar et al, 1994). In the present chapter, it is intended to discuss only recent reports on lectin histochemistry.…”

Section: Exogenous Lectins In Histopathologymentioning

confidence: 99%

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Lectins and Neoglycoproteins in Histopathology

Kannan¹,

Mk²

1996

Glycosciences

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“…Pflanzliche Lektine finden Einsatz als histopathologischcs Instrument, mit dem Expression von durch die Lektinspezifi tät definierten Glykokonjugatstrukturcn in Tumoren nach gewiesen werden kann [1,15,16,19]. So hat sich das fukosespezifische Lektin UEA-1 als verläßlicher Marker für Tumore vaskulären Ursprungs bewährt [67].…”

Section: Ist Die Histopathologischc Lokalisation Von Zuckerrezeptorenunclassified

Endogene Lektine in Tumoren und ihre mögliche Bedeutung für Diagnose und Therapie von Krebserkrankungen

Gabius¹

1989

Oncol Res Treat

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Die Einbeziehung des Wissens um biologische Erkennungsprozesse in die Onkologie belegt den folgerichtigen Weg, Resultate der Grundlagenforschung nutzbringend in klinísche Verfahren zur Tumordiagnose und -therapie umzusetzen. Unter der begründeten Annahme, daß biologische Information auch in einem glykobiochemischen Code-system in den Zuckerketten zellulärer Glykokonjugate gespeichert werden kann, verdienen Zucker-Protein-Interaktionen besondere Aufmerksamkeit. Lektine bilden eine eigenständige Klasse zuckerbindender Proteine, abgegrenzt von zuckerspezifischen Enzymen und Antikörpern. Sie werden von Normalzellen, aber auch von Tumorzellen exprimíert. Ihr Expressionsmuster wird in histopathologischen Standardverfahren durch Einsatz markierter Träger, die definiert durch synthetische Anheftung der histochemisch entscheidenden Zuckerreste modifiziert sind, erfaßt. Die anhand des Einsatzes solcher Neoglykoproteine dokumentierten tumorassoziierten Unterschiede dienen als Leitlinien für anknüpfende biochemische Charakterisierung der individuellen Zuckerrezeptoren und für «lectin-mediated drug targeting». Erhöhte Selektívität der Aufnahme von Therapeutika, die an Neoglykoproteine gekoppelt sind, soil durch Nutzung des Lektinmusters erreicht werden. Neben diesem Beitrag der Tumorlektinologie zur möglichen Anwendung in der onkologischen Praxis läßt sich die Annahme der beachtenswerten Bedeutung von Zucker-Protein-Erkennung prinzipiell auch auf ein herausragendes wie komplexes Problem der Tumorforschung anwenden, die Metastasierung. Übergreifender Einsatz chemischer, biochemischer, zellbiologischer. histochemischer und onkologischer Methoden wird es ermöglichen, den Wert der Tumorlektinologie in der Onkologie kritisch einzuschätzen.

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Lectins and Blood Group Substances as “Tumor Markers”

Cited by 42 publications

References 95 publications

Clonal analysis of a bladder cancer cell line: an experimental model of tumour heterogeneity

Clonal analysis of a bladder cancer cell line: an experimental model of tumour heterogeneity

Lectins and Neoglycoproteins in Histopathology

Endogene Lektine in Tumoren und ihre mögliche Bedeutung für Diagnose und Therapie von Krebserkrankungen

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