LED-based photoacoustic imaging for preoperative visualization of lymphatic vessels in patients with secondary limb lymphedema

Heumen, Saskia van; Riksen, Jonas J. M.; Singh, Mithun Kuniyil Ajith; Soest, Gijs van; Vasilic, Dalibor

doi:10.1016/j.pacs.2022.100446

Cited by 10 publications

(18 citation statements)

References 63 publications

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“…173 Alternatively, untargeted exogenous contrast may be administered, which highlight areas where the contrast agent pools, such as in dysfunctional lymphatic vessels. 168 PACAs offer a relative freedom in choosing the wavelengths that generate contrast, and major biological chromophore absorption bands can potentially be avoided. Many absorbing (nano)particles and dyes that are used as PACAs have originally been developed as fluorescent agents and thus have been designed to re-emit part of the absorbed energy as optical radiation.…”

Section: Contrast Agentsmentioning

confidence: 99%

“…179 The Acoustic X (Cyberdyne Inc., Tsukuba, Japan) is a handheld, pre-clinical PA/ultrasound system that is applied in various clinical research areas, such as the detection of joint inflammation, 180 port-wine stain imaging assessment, 181 and lymphatic vessel imaging. 168 It is an LEDbased system with a 128-element linear array transducer with a center frequency of 7 or 10 MHz. The illumination is provided with side-illuminating high-density, high-power LED strips at fixed wavelengths of 690, 750, 820, 850, and 940 nm (combinations 690/850, 750/850, and 820/940 nm).…”

Section: Commercial Systems Overviewmentioning

confidence: 99%

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Photoacoustic imaging on its way toward clinical utility: a tutorial review focusing on practical application in medicine

2023

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Photoacoustic imaging (PAI) enables the visualization of optical contrast with ultrasonic imaging. It is a field of intense research, with great promise for clinical application. Understanding the principles of PAI is important for engineering research and image interpretation.Aim: In this tutorial review, we lay out the imaging physics, instrumentation requirements, standardization, and some practical examples for (junior) researchers, who have an interest in developing PAI systems and applications for clinical translation or applying PAI in clinical research.Approach: We discuss PAI principles and implementation in a shared context, emphasizing technical solutions that are amenable to broad clinical deployment, considering factors such as robustness, mobility, and cost in addition to image quality and quantification.Results: Photoacoustics, capitalizing on endogenous contrast or administered contrast agents that are approved for human use, yields highly informative images in clinical settings, which can support diagnosis and interventions in the future.Conclusion: PAI offers unique image contrast that has been demonstrated in a broad set of clinical scenarios. The transition of PAI from a "nice-to-have" to a "need-to-have" modality will require dedicated clinical studies that evaluate therapeutic decision-making based on PAI and consideration of the actual value for patients and clinicians, compared with the associated cost.

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Section: Contrast Agentsmentioning

confidence: 99%

Section: Commercial Systems Overviewmentioning

confidence: 99%

Photoacoustic imaging on its way toward clinical utility: a tutorial review focusing on practical application in medicine

2023

Self Cite

View full text Add to dashboard Cite

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“…For all the phantom and human volunteer imaging experiments, we used the commercially available LED-based PA and US imaging system (AcousticX, CYBERDYNE INC, Japan) (Fig. 1a) [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] . AcousticX is the only plug-and-play PA and US imaging system commercially available in the market now.…”

Section: Led-based Pa and Us Imaging System (Acousticx)mentioning

confidence: 99%

“…9 We recently developed and commercialized an LED-based PA and US imaging system (AcousticX) and have already demonstrated its potential in multiple preclinical applications and early clinical pilot studies. [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] In AcousticX, clinical linear array US probes and high-power LED arrays are used in a handheld probe to perform real-time 2D US, PA, and oxygen saturation imaging. 10 In our previous work, we implemented automatic linear scanning of the AcousticX PA/US probe to generate 3D PA and US MIP images of the human vasculature.…”

Section: Introductionmentioning

confidence: 99%

Improving 3D imaging capability of LED-based photoacoustic imaging for high resolution human vascular imaging applications

Singh¹,

Sato²,

Ichihashi³

et al. 2023

Photons Plus Ultrasound: Imaging and Sensing 2023

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Visualizing blood vessel networks in 3D is helpful in many superficial vascular imaging applications. We previously reported the feasibility of LED-based photoacoustic imaging in visualizing human vasculature in 3D by linear translation of combined photoacoustic/ultrasound imaging probe. In this work, we improved this 3D imaging functionality by 1) automatic removal of skin PA signal in different 2D slices by ultrasound-based lineation , 2) encoding depth information with different colors and 3)improving the grayscale and hot color maps. All these new features were implemented in the system software and we validated these using phantom and human in vivo imaging experiments. Results demonstrate that the newly implemented features significantly improved the 3D imaging capability in our LED-based photoacoustic and ultrasound imaging system. We believe that the improved 3D imaging functionality in the system will be potentially useful for multiple preclinical and clinical applications in which the visualization of vasculature in 3D is a prerequisite.

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“…6 We recently developed and commercialized an LED-based PA and US imaging system (AcousticX) as an alternative to laser-based equipment and have already demonstrated its potential in multiple preclinical applications and early clinical pilot studies. [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] In this work, we used AcousticX to evaluate the potential of real-time two-wavelength LED-based PA imaging in estimating oxygen saturation (sO2) in vivo. We performed three live rat imaging experiments in which vascular sO2 was imaged continuously using AcousticX while the animal was breathing pure nitrogen gas to induce hypoxia.…”

Section: Introductionmentioning

confidence: 99%

Oxygen saturation imaging using dual-wavelength LED-based photoacoustics

Singh¹,

Sato²,

Tsunoi³

et al. 2023

Photons Plus Ultrasound: Imaging and Sensing 2023

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Since hypoxia is an early marker for cancer and several microvascular disorders, imaging oxygen saturation with high resolution has profound importance in multiple preclinical and clinical imaging studies. In this work, we demonstrate the potential of dual-wavelength (690/850 nm) LED-based photoacoustic imaging in high resolution real-time oxygen saturation imaging in vivo. We performed two live rat imaging experiments in which the oxygen saturation of the bloodvessels in the left hindlimb was imaged for 20 seconds while the animal was breathing pure nitrogen gas to induce hypoxia. For a comparison, we continuously monitored the oxygen level using a pulse oximeter connected to the forelimb. In another experiment, we performed imaging of oxygen saturation changes in the tail vein of the rat while hypoxia was induced over the period of 40 seconds. In this case also, pulse oximeter readings were recorded for a comparison. In all the experiments, photoacoustic-based oxygen saturation values measured over time followed the same trend as the reference values provided by the pulse oximeter. Also, our two wavelength LED-based photoacoustic imaging approach was found to be sensitive even for 3% change in oxygen saturation. Results give a direct confirmation about the potential of LED-based photoacoustic imaging in detection of oxygen saturation with high spatio-temporal resolution, making it an ideal tool for hypoxia detection in longitudinal preclinical and clinical imaging studies.

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LED-based photoacoustic imaging for preoperative visualization of lymphatic vessels in patients with secondary limb lymphedema

Cited by 10 publications

References 63 publications

Photoacoustic imaging on its way toward clinical utility: a tutorial review focusing on practical application in medicine

Photoacoustic imaging on its way toward clinical utility: a tutorial review focusing on practical application in medicine

Improving 3D imaging capability of LED-based photoacoustic imaging for high resolution human vascular imaging applications

Oxygen saturation imaging using dual-wavelength LED-based photoacoustics

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