Left atrial phasic function and heart rate variability in asymptomatic diabetic patients

Tadić, Marijana; Vukomanovic, Vladan; Cuspidi, Cesare; Suzić-Lazić, Jelena; Stanisavljević, Dejana; Celic, Vera

doi:10.1007/s00592-016-0962-x

Cited by 23 publications

(26 citation statements)

References 31 publications

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“…Eight studies did not report HbA1c in the T2DM patients [43,45,46,48,50,53,61,64] and nine studies did not specify for the controls [43,[45][46][47][48]50,53,61,64]. Blood glucose levels were reported in 14 studies [42,44,46,47,51,52,55,58,[60][61][62][63]65,66] with a mean blood glucose level of 147±16 mg/ dL in T2DM patients, ranging from 117 [47] to 168 [58,62], and 90±6 in controls, ranging from 75 [46] to 95 [55]. Blood insulin levels were reported in one study [44].…”

Section: Populationmentioning

confidence: 99%

“…Blood lipid levels. Total cholesterol was reported in nine studies [42,47,51,54,55,61,62,65,66]. HDL and LDL cholesterol in six studies [47,55,[60][61][62]65] and triglycerides in 12 studies [42,47,51,55,56,[58][59][60][61][62]65,66].…”

Section: Populationmentioning

confidence: 99%

“…All included studies measured HRV over 24 consecutive hours using a Holter-electrocardiogram. HRV measurement recording was ambulatory with normal daily activity in most of the studies [42][43][44][45][47][48][49][50][51]53,54,[56][57][58]60,62,[64][65][66], ambulatory in non-dialysed patients and during hospitalization for dialysed patients in two studies [46,52], and exclusively during hospitalization in one study [59]. Three studies did not report the conditions of the measurements [55,61,63].…”

Section: Hrv Measurements and Analysismentioning

confidence: 99%

“…Nearly all studies had a distinct Holter monitoring system: Del Mar Reynolds Medical [61], CardioSmart Institutional CS 550 software [58], Holter cardio Light digital [62], Zymed Medical Instruments [48], Mortara Instruments [53,57], TM 2421 & 2425 systems [56], Holter AD35 TOP [46], Marquette Electronics [43], Meditech Cardiotens [54,55], Fukuda System [44], Spiderview Holter [52], Cardioscan DMS300-4 Model [63], Holter Digital Recorder AsPEKT [42,51], ArguSys Holter Monitor [47], CardioDay GETEMED [59]. Schiller Microvit MT-101 [65,66], and A&D System [49]. Four studies did not report the monitoring system [45,50,60,64], Fifteen studies explicitly mentioned that they followed task force recommandations [42,44,45,47,48,[51][52][53][54][55][56]58,59,61,62].…”

Section: Hrv Measurements and Analysismentioning

confidence: 99%

“…We noted strong evidence that T2DM patients had significantly lower RR intervals (effect size = -0.61; 95%CI -1.21 to -0.01, P = 0.01; I 2 = 91.6%) (Fig 2) [45,46,48,52,54,57], lower SDNN (effect size = -0.65; 95%CI -0.83 to -0.47; P < 0.001; I 2 = 65.1%) (Fig 3) [42,45,47,48,[50][51][52][53]55,57,58,[60][61][62][63][64][65][66], lower RMSSD (effect size = -0.92; 95%CI -1.37 to -0.47); P < 0.001; I 2 = 94.0%) (Fig 4) [45,47,48,50,52,53,[56][57][58][60][61][62][63][64][65][66], lower pNN50 (effect size = -0.46; 95%CI -0.84 to -0.09; P = 0.001; I 2 = 85.5%) ( Fig 5) [42,48,[50][51]…”

Section: Meta-analyses Of Hrv Values In T2dmmentioning

confidence: 99%

See 4 more Smart Citations

Heart rate variability in type 2 diabetes mellitus: A systematic review and meta-analysis

Benichou

Pereira

Mermillod

et al. 2018

Annales d'Endocrinologie

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BackgroundCardiac autonomic neuropathy in type 2 dibetes mellitus (T2DM) patients is frequent and associated with high cardiovascular mortality. Heart rate variability (HRV) is the gold standard to measure cardiac autonomic neuropathy. We aimed to conduct a systematic review and meta-analysis to evaluate the impact of T2DM on HRV parameters. OPEN ACCESS Citation: Benichou T, Pereira B, Mermillod M, Tauveron I, Pfabigan D, Maqdasy S, et al. (2018) Heart rate variability in type 2 diabetes mellitus: A systematic review and meta-analysis. PLoS ONE 13(4): e0195166. https://doi.org/10.-2.13 to -0.91), lower LF (-1.08; -1.46 to -0.69]), and lower HF (-0.79; -1.09 to -0.50). LF/HF did not differ between groups. Levels of blood glucose and HbA1c were associated with several HRV parameters, as well as Time from diagnosis of T2DM ConclusionsT2DM was associated with an overall decrease in the HRV of T2DM patients. Both sympathetic and parasympathetic activity were decreased, which can be explained by the deleterious effects of altered glucose metabolism on HRV, leading to cardiac autonomic neuropathy.

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Section: Populationmentioning

confidence: 99%

Section: Populationmentioning

confidence: 99%

Section: Hrv Measurements and Analysismentioning

confidence: 99%

Section: Hrv Measurements and Analysismentioning

confidence: 99%

Section: Meta-analyses Of Hrv Values In T2dmmentioning

confidence: 99%

See 3 more Smart Citations

Heart rate variability in type 2 diabetes mellitus: A systematic review and meta-analysis

Benichou

Pereira

Mermillod

et al. 2018

Annales d'Endocrinologie

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Left atrial function in diabetes: does it help?

Tadić

Cuspidi

2020

Acta Diabetol

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The impact of lifestyle intervention on left atrial function in type 2 diabetes: results from the DIASTOLIC study

Alfuhied

Gulsin

Athithan

et al. 2022

Int J Cardiovasc Imaging

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Aerobic exercise training and low energy diets have been shown to improve left ventricular remodelling and diastolic function in adults with type 2 diabetes (T2D), albeit with differential effects. The impact of these lifestyle interventions on left atrial (LA) function, however, has not previously been reported. The DIASTOLIC study was a prospective, randomised, open-label, blind endpoint trial, in which 90 people with obesity and T2D and no prevalent cardiovascular disease were randomised to a 12-week intervention of: (i) routine care, (ii) aerobic exercise training, or (iii) low energy (≈ 810 kcal/day) meal replacement plan (MRP). Cardiac magnetic resonance (CMR) imaging was performed pre- and post-intervention. Image analysis included LA volumes (LAV), emptying fraction (LAEF), and LA strain (LAS) corresponding to LA reservoir (LAS-r), conduit (LAS-cd), and booster pump (LAS-bp) function. 73 participants with T2D (mean age 50 ± 6 years, 62% male, body mass index (BMI) 36.1 ± 5.3 kg/m2) completed the trial and had analysable LA images. There was no significant change in CMR measured LA volumetric function (LAV/LAEF) in any group. The routine care group showed no significant change in BMI or LAS. In the MRP group, there were significant reductions in BMI (4.5 kg/m2) and a significant increase in LAS-r and LAS-bp (29.9 ± 7.0 to 32.3 ± 7.0%, p = 0.036 and 14.6 ± 5.3 to 17.2 ± 3.7%, p = 0.034). The exercise group showed a small reduction in BMI (0.49 kg/m2), with no significant change in LAS. Compared to routine care, weight loss via a 12-week MRP, led to improvements in LA filling and contractile function in adults with T2D and obesity. However, these within-group changes were not statistically significant on between-group comparison. ClinicalTrials.gov Identifier: NCT02590822.

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Left atrial phasic function and heart rate variability in asymptomatic diabetic patients

Cited by 23 publications

References 31 publications

Heart rate variability in type 2 diabetes mellitus: A systematic review and meta-analysis

Heart rate variability in type 2 diabetes mellitus: A systematic review and meta-analysis

Left atrial function in diabetes: does it help?

The impact of lifestyle intervention on left atrial function in type 2 diabetes: results from the DIASTOLIC study

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