Left atrial pressure, plasma osmolality, and ADH levels in the unanesthetized ewe

Zehr, JE; Johnson, J. A.; Moore, W W

doi:10.1152/ajplegacy.1969.217.6.1672

Cited by 42 publications

(11 citation statements)

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“…Control levels for plasma ADH in the jugular or arterial plasma of the sheep were somewhat higher than those reported for other animals (Zehr, Johnson & Moore, 1969). However, the values obtained from the sheep were not basal, probably because the sheep were slightly stressed by being lightly restrained on their backs and having undergone minor surgery.…”

Section: Discussioncontrasting

confidence: 54%

Radioimmunoassay for Plasma Antidiuretic Hormone

Johnston¹

1972

Journal of Endocrinology

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Antibodies to [8-lysine]-vasopressin (LVP) were produced in rabbits by a macrophage harvesting technique. Using these antibodies a radioimmunoassay for vasopressin was established using LVP as standard and for labelling with 125I. The antibody demonstrated complete cross-reactivity to [8-arginine]-and [8-ornithine]-vasopressin but concentrations of oxytocin 1000 times greater caused no displacement. A simple extraction procedure for antidiuretic hormone (ADH) in plasma is described. Employing this extraction procedure followed by radioimmunoassay, plasma levels of ADH were measured in sheep. The mean level of plasma ADH in nine sheep was found to be 5\m=.\28\m=+-\1\m=.\18in arterial blood and this rose to 21\m=.\04\m=+-\ 7\m=.\29 \ g=m\ u. / ml after haemorrhage of 10 to 20% of their blood volume.

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Section: Discussioncontrasting

confidence: 54%

Radioimmunoassay for Plasma Antidiuretic Hormone

Johnston¹

1972

Journal of Endocrinology

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“…It also reduced plasma osmolality this being an important regulator of body¯uid balance. Such changes are typically seen after ingestion of large amounts of water (Zehr et al 1969). Recently it has been observed, that i.c.v.…”

Section: Discussionmentioning

confidence: 99%

Metoprine-induced thirst and diuresis in Wistar rats

Lecklin

Eriksson²,

Leppäluoto³

et al. 1999

Acta Physiologica Scandinavica

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In the present study, the renal responses to metoprine, a histamine-N-methyltransferase inhibitor, were studied in conscious rats. Metoprine (10-20 mg kg(-1)) or vehicle were administered i.p. to male Wistar rats and the effects were followed for the subsequent 24 h. It was found that as early as 3 h after the drug administration metoprine 20 mg kg(-1) had increased water consumption and urine flow approximately 6-8-fold. The treatment decreased urine osmolality and increased free water clearance, but caused no change in plasma renin activity or plasma vasopressin concentration. In addition, a metoprine-induced elevation in the systolic blood pressure was observed during the first few hours of the experiment. During the nocturnal period of the study, glomerular filtration rate and the excretion of electrolytes did not increase in metoprine-treated rats as they did in control rats. A decrease in the release of atrial natriuretic peptide was also found. The present results show that inhibition of histamine catabolism by metoprine causes massive changes in renal functions. It seems to promote water excretion by the kidneys but, on the other hand, to reduce the excretion of electrolytes. Although the exact mechanisms, especially the role of increased blood pressure and nocturnal suppression of atrial natriuretic peptide, require further clarification, the present data suggest that renin-angiotensin system and vasopressin were not involved in these renal responses to metoprine.

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“…The experimental conditions precluded the role of posture or environ mental temperature [31]. Stimulation by a decrease in left atrial pressure due to hypovolemia [3][4][5] was unlikely because predialysis body weight was at least 1 % greater than DB W. Hypertonicity also does not explain the tendency for high plasma ADH values in some of these anephric patients. In fact, four patients had predialysis ADH values of 0.4-13.1 ¡xU/ml despite an [OsmC O rr]p below the 95% confidence limit (280.2 mOsm/1) for osmotic stimulation of ADH release in water-loaded normal subjects [32], a condition in which plasma ADH is immeasurable [33], Surgical stress can probably be excluded as a cause of the higher plasma ADH levels before dialysis, because of the time elapsed after nephrectomy [34].…”

Section: Discussionmentioning

confidence: 99%

“…The change in plasma ADH during dialysis was significantly correlated only with the change in plasma calcium (r = 0.47, p < 0.05). The data support the hypothesis that plasma calcium plays a role in the regulation of ADH release in man, independent of the renin-aldosterone system.The release of stored antidiuretic hormone (ADH) in the neurosecretory axons of the posterior pituitary gland is regulated by a number of physio logical stimuli which probably act via synaptic input of the hypothalamic centers involved in the synthesis of the hormone [1], These stimuli include changes in plasma osmolality [2], left atrial pressure [3][4][5] and systemic arterial pressure [6]. Recently, Bonjour and Malvin [7] have shown a role of the renin-angiotensin hormonal axis in ADH control.…”

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confidence: 99%

The Effect of Plasma Calcium on Plasma ADH Levels in Anephric Patients

Pastoriza-Munoz¹,

Easterling²,

Malvin³

1976

Nephron

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Ten anephric patients were studied before and during hemodialysis. The extracorporeal circuit was primed with 5% albumin in 0.9% sodium chloride. Ultrafiltration volume removed by the hemodialyzer was replaced continuously. Modifications of a standard chronic renal failure dialysate were used to minimize changes in plasma urea while varying plasma sodium and calcium in opposite directions. Plasma ionized calcium concentrations in two patients confirmed other studies demonstrating a correlation between plasma total calcium and ionized calcium under these conditions. Plasma ADH determined by bioassay did not correlate with plasma osmolality, plasma sodium concentration, plasma potassium concentration, blood pressure, or pulse rate. The change in plasma ADH during dialysis was significantly correlated only with the change in plasma calcium (r = 0.47, p < 0.05). The data support the hypothesis that plasma calcium plays a role in the regulation of ADH release in man, independent of the renin-aldosterone system.

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Left atrial pressure, plasma osmolality, and ADH levels in the unanesthetized ewe

Cited by 42 publications

References 0 publications

Radioimmunoassay for Plasma Antidiuretic Hormone

Radioimmunoassay for Plasma Antidiuretic Hormone

Metoprine-induced thirst and diuresis in Wistar rats

The Effect of Plasma Calcium on Plasma ADH Levels in Anephric Patients

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