Left atrial, ventricular and atrio-ventricular strain in patients with subclinical heart dysfunction

Cameli, Matteo; Mandoli, Giulia Elena; Lisi, Edoardo; Ibrahim, Aladino; Incampo, Eufemia; Buccoliero, Gianluigi; Rizzo, Clara; Devito, Fiorella; Ciccone, Marco Matteo; Mondillo, Sergio

doi:10.1007/s10554-018-1461-7

Cited by 58 publications

(52 citation statements)

References 44 publications

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“…Specifically, the mean duration of diabetes in the longerterm T2DM group was approximately 11 years in Liu's study [30], whereas the duration in our study was relatively short at only approximately 8 years. In this study, we also found that the LA strain changed significantly, indicating that LA deformation-related impairment could appear even earlier than the LV strain in the early stages of DCM, a finding that is consistent with Cameli's study [31]. This finding revealed that LV strain did not represent the most accurate parameter for detecting early damage in those patients.…”

Section: Discussionsupporting

confidence: 83%

“…This finding revealed that LV strain did not represent the most accurate parameter for detecting early damage in those patients. A possible explanation may be related to anatomy: the LA is a very thin, singlelayer wall that is very sensitive to even subtle stimuli [31]. Therefore, LA strain, as an early parameter, may have been more sensitive than LV strain for the detection of early DCM in our study.…”

Section: Discussionmentioning

confidence: 82%

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Early detection of left atrial and bi-ventricular myocardial strain abnormalities by MRI feature tracking in normotensive or hypertensive T2DM patients with preserved LV function

Shao

Cao

Cui

et al. 2020

BMC Cardiovasc Disord

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Background: Previous studies have found that impaired global myocardial systolic strain is associated with cardiovascular events in T2DM patients. However, the effect of hypertension (HT) on left atrial (LA), right ventricular (RV) and left ventricular (LV) myocardial deformation in hypertensive T2DM patients has not been fully studied by cardiac magnetic resonance feature tracking (CMR-FT). Our aim was to assess LA, RV and LV strain in T2DM patients with T2DM-HT and without hypertension using CMR-FT and to determine the underlying relationships with clinical parameters. Methods: A total of 27 T2DM patients, 23 T2DM-HT patients and 31 controls were studied. LA, LV and RV strain was evaluated using CMR-FT. The clinical and biochemical parameters of the patients were collected. Results: The T2DM patients had reduced LA global circumferential strain (LAGCS), radial strain (LAGRS), longitudinal strain (LAGLS) and right ventricular longitudinal strain (RVGLS) compared with the controls (LAGCS: 27.2 ± 2.1% vs 33.5 ± 2.4%; LAGRS:

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 82%

Early detection of left atrial and bi-ventricular myocardial strain abnormalities by MRI feature tracking in normotensive or hypertensive T2DM patients with preserved LV function

Shao

Cao

Cui

et al. 2020

BMC Cardiovasc Disord

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“…SBP was chosen as such as a factor due to its known association to myocardial GLS in different patient groups [16] and the high prevalence of arterial hypertension worldwide. Another important aspect is that myocardial GLS decline in hypertensives reflects subclinical damage of LV structure and function due to early microscarring of the subendocardium, especially in the highly hypertrophied muscles [42]. Furthermore, increased afterload is known to prolong contraction and delay active relaxation [43] and reduce longitudinal strain and strain-rate [44].…”

Section: Myocardial Gls and Bpmentioning

confidence: 99%

Global myocardial longitudinal strain in a general population—associations with blood pressure and subclinical heart failure: The Tromsø Study

Stylidis

Leon

Røsner

et al. 2019

Int J Cardiovasc Imaging

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The early detection of subclinical myocardial dysfunction can contribute to the treatment and prevention of heart failure (HF). The aim of the study was to (i) describe myocardial global longitudinal strain (GLS) patterns in a large general population sample from Norway and their relation to established cardiovascular disease (CVD) risk factors; (ii) to determine its normal thresholds in healthy individuals and (iii) ascertain the relation of myocardial GLS to stage A subclinical heart failure (SAHF). Methods: Participants (n=1855) of the 7 th survey of the population-based Tromsø Study of Norway (2015-2016) with GLS measurements were studied. Linear and logistic regression models were used for assessment of the associations between CVD risk factors and GLS. Results: Mean GLS (SD) in healthy participants was-15.9 (2.7)% in men and-17.8 (3.1)% in women. Among healthy subjects, defined as those without known cardiovascular diseases and comorbidities, GLS declined with age. An increase of systolic blood pressure (SBP) of 10 mm Hg was associated with a 0.2% GLS reduction. Myocardial GLS in individuals with SAHF was 1.2% lower than in participants without SAHF (p<0.001). Conclusion: Mean myocardial GLS declines with age in both sexes, both in a general population and in the healthy subsample. SBP increase associated with GLS decline in women. Our findings indicate high sensitivity of GLS for early subclinical stages of HF.

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“…The transition from an asymptomatic to a symptomatic state is very hard to disclose but at the same time essential to define the best timing to operate. Even though global longitudinal strain (GLS) is altered before a decrease in LVEF or before LV dilatation, evidence suggests that an impairment of LAS might precede clear LV strain deterioration in different clinical settings, such as valvular heart disease and diastolic dysfunction …”

Section: Discussionmentioning

confidence: 99%

The role of the left atrial function in the surgical management of aortic and mitral valve disease

et al. 2019

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The right management of both mitral and aortic disease can be challenging, especially in asymptomatic patients. The current guidelines recommend valve repair or replacement when symptoms arise or when there is an evident left ventricular dysfunction. However, deciding the optimal surgical timing can be very difficult, since the line between the absence of symptoms and being minimally symptomatic, especially in the elderly, is blurred. Another relevant issue regards the second surgical criterion: operating on a patient with a reduced left ventricular ejection fraction or with a dilated left ventricle might jeopardize the possibility of a fully reverse remodeling of the heart after surgery. In this scenario, the left atrium might play an important role. In particular, left atrial deformation might be a very useful tool to detect early ultrastructural alterations, and help or support guiding a patient‐tailored treatment at an early stage, optimizing the outcome in the long term.

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Left atrial, ventricular and atrio-ventricular strain in patients with subclinical heart dysfunction

Cited by 58 publications

References 44 publications

Early detection of left atrial and bi-ventricular myocardial strain abnormalities by MRI feature tracking in normotensive or hypertensive T2DM patients with preserved LV function

Early detection of left atrial and bi-ventricular myocardial strain abnormalities by MRI feature tracking in normotensive or hypertensive T2DM patients with preserved LV function

Global myocardial longitudinal strain in a general population—associations with blood pressure and subclinical heart failure: The Tromsø Study

The role of the left atrial function in the surgical management of aortic and mitral valve disease

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