Left Atrium Size and the Risk of Cardiovascular Death in Middle-aged Men

Laukkanen, Jari A.; Kurl, Sudhir; Eränen, Jaakko; Huttunen, Matti; Salonen, Jukka T.

doi:10.1001/archinte.165.15.1788

Cited by 145 publications

(80 citation statements)

References 30 publications

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“…This information was collected from the coronary intervention registry. Echocardiographic studies were performed with the Advanced Technologies and Laboratories International, Inc (ATL) Ultramark IV device for 905 randomly selected men 14 15. Left ventricular function was assessed with fractional shortening for 897 men.…”

Section: Methodsmentioning

confidence: 99%

Cardiorespiratory fitness and exercise-induced ST segment depression in assessing the risk of sudden cardiac death in men

Hagnäs

Lakka

Kurl

et al. 2016

Heart

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Section: Methodsmentioning

confidence: 99%

Cardiorespiratory fitness and exercise-induced ST segment depression in assessing the risk of sudden cardiac death in men

Hagnäs

Lakka

Kurl

et al. 2016

Heart

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“…Left ventricular (LV) end diastolic and end systolic internal shortaxis dimensions were among the measures collected. 18 All the echocardiographic assessments were performed and interpreted by one cardiologist. Echocardiography was not available for the all men included in the prospective KIHD study, which was focused on exercise testing.…”

Section: Echocardiographymentioning

confidence: 99%

Peak oxygen pulse during exercise as a predictor for coronary heart disease and all cause death

Laukkanen

Kurl²,

Salonen³

et al. 2006

Heart

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Objective: To investigate the prognostic value of peak oxygen pulse, which is the amount of oxygen consumed per heart beat during exercise, and to compare the prognostic value of peak oxygen pulse and maximum oxygen uptake (V O 2max ) with respect to coronary heart disease (CHD) and overall death. Design: Prospective population-based study based on 1596 men without CHD or the use of b blockers at baseline. Results: The risk of CHD was 2.45 (95% CI 1.10 to 5.45) times higher in men with low peak oxygen pulse (, 13.5 ml/beat) than in those with high peak oxygen pulse (. 17.8 ml/beat) after adjustment for age, alcohol consumption, smoking, body mass index, blood pressure, serum lipids, diabetes, family history of CHD and ischaemic ST changes during exercise. During an average follow up of 14 years, 267 men died, 67 of them due to CHD. The respective risk for overall death was 1.79 (95% CI 1.21 to 2.65). The continuous variable V O 2max was a stronger risk predictor than peak oxygen pulse for CHD and overall death. Conclusions: Assessment of oxygen pulse provides no complementary information to V O 2max about cardiorespiratory fitness and prognosis for CHD. The analysis of respiratory gas exchange including the assessment of oxygen pulse during exercise does, however, provide an additional means for defining prognosis for patients with CHD.

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“…Failure to correct the hidden volume expansion may at least partially explain the persistence or development of LVH. This finding is supported by studies on daily HD [142], a treatment modality that greatly facilitates volume control. In patients on nocturnal HD, there is a notable reduction in the LVMI and in LV function [143].…”

Section: Peritoneal Dialysis: Animal Model and Patientsmentioning

confidence: 53%

Pathogenesis and Treatment of Chronic Kidney Disease: A Review of Our Recent Basic and Clinical Data

Tomino

2014

Kidney Blood Press Res

439

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Chronic kidney disease (CKD) is a worldwide public health problem that affects millions of people from all racial and ethnic groups. At end of 2013, over 300,000 Japanese patients had maintenance dialysis therapy (JSDT). In Japan, the major causes of end stage kidney disease (ESKD) are chronic glomerulonephritis (particularly IgA nephropathy), type 2 diabetic nephropathy, and hypertensive nephrosclerosis. Hypertension is a major factor driving the progression of CKD to ESKD. Since many features of the pathogenesis of IgA nephropathy are still obscure, specific treatment is not yet available. However, efforts by investigators around the world have gradually clarified different aspects of the pathogenesis and treatment of IgA nephropathy. Today, around half of all diabetic patients in Japan receive medical treatment. Type 2 diabetic nephropathy is one of the major long-term microvascular complications occurring in nearly 40% of Japanese diabetic patients. The pathogenesis of diabetic nephropathy involves both genetic and environmental factors. However, the candidate genes related to the initiation and progression of the disorder are still obscure in patients with diabetic nephropathy. Regarding environmental factors, the toxicity of persistent hyperglycemia, reactive oxygen species, systemic and/or glomerular hypertension, dyslipidemia and complement are considered to play an important role. The first part of this review covers the pathogenesis of IgA nephropathy and type 2 diabetic nephropathy, and combines the clinicopathological findings in patients with our research on the ddY and KKA-y mouse models (spontaneous animal models for IgA nephropathy and diabetic nephropathy, respectively). In Japan, the major renal replacement therapies (RRT) are peritoneal dialysis (PD) and hemodialysis (HD). The second part of this review focuses on PD and HD. Based on our research findings from patients and as well as from animal models, we discuss strategies for the management of patients on PD and HD. i 2015 S. Karger AG, Basel

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Left Atrium Size and the Risk of Cardiovascular Death in Middle-aged Men

Abstract: This prospective population-based study shows that echocardiographically defined LA diameter was directly related to the risk of cardiovascular death. The association of LA enlargement to cardiovascular death appears to be partially related to LV hypertrophy.

Cited by 145 publications

References 30 publications

Cardiorespiratory fitness and exercise-induced ST segment depression in assessing the risk of sudden cardiac death in men

Cardiorespiratory fitness and exercise-induced ST segment depression in assessing the risk of sudden cardiac death in men

Peak oxygen pulse during exercise as a predictor for coronary heart disease and all cause death

Pathogenesis and Treatment of Chronic Kidney Disease: A Review of Our Recent Basic and Clinical Data

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