Left dorsolateral prefrontal transcranial magnetic stimulation (TMS): Sleep factor changes during treatment in patients with pharmacoresistant major depressive disorder

Rosenquist, Peter B.; Krystal, Andrew D.; Heart, Karen; Demitrack, Mark A.; McCall, W. Vaughn

doi:10.1016/j.psychres.2012.09.011

Cited by 29 publications

(13 citation statements)

References 50 publications

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“…This is opposed to an effect of the sleep initiation or wake/attention promoting systems as both the latency to N1, the MWT, and the PVT measures were not affected by TBS. In this sense, the null results for those measures in support of earlier studies on the effects of TMS on sleep and vigilance (Cohrs et al, 1998; Graf et al, 2001; Rosenquist et al, 2013). Although this study cannot determine the physiological mechanism of such an effect, it may not be unlike that of sodium oxybate at certain doses.…”

Section: Resultssupporting

confidence: 81%

“…Six weeks after TMS treatment, overall patients did not show any effect on subjective sleep measures. However, in a subgroup of patients that showed reliable improvement to their depression symptoms did also show a concurrent improvement to sleep parameters, although the authors argue that this is a reflection on the efficacy of treatment, and not on the influence of TMS on sleep directly (Rosenquist et al, 2013). …”

Section: Introductionmentioning

confidence: 99%

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The effects of theta-burst stimulation on sleep and vigilance in humans

Mensen

Gorban

Niklaus

et al. 2014

Front. Hum. Neurosci.

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Repetitive transcranial magnetic stimulation (TMS) has become a popular tool to modulate neuronal networks and associated brain functions in both clinical and basic research. Yet few studies have examined the potential effects of cortical stimulation on general levels of vigilance. In this exploratory study, we used theta-burst protocols, both continuous (cTBS) and intermittent (iTBS) patterns, to examine whether inhibition or excitation of the left dorso-lateral prefrontal cortex (dlPFC) was able to induce reliable and acute changes to vigilance measures, compared to the left dorso-lateral associative visual cortex (dlAVC) as a control site in line with previous work. Partially sleep restricted participants underwent four separate sessions in a single day, in a between subjects design for TBS stimulation type and within subjects for locaton, each consisting of maintenance of wakefulness test (MWT), a sleep latency test, and a psychomotor vigilance task (PVT). TBS significantly affected measures of sleep consolidation, namely latency to sleep stage 2 and sleep efficiency, but had no effects on sleep drive or psychomotor vigilance levels for either TBS type or location. Contrary to our initial hypothesis of the dlAVC as a control site, stimulation to this region resulted in the largest differential effects between stimulation types. Moreover, the effect of TBS was found to be consistent throughout the day. These data may provide the basis for further investigation into therapeutic applications of TBS in sleep disorders.

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Section: Resultssupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

The effects of theta-burst stimulation on sleep and vigilance in humans

Mensen

Gorban

Niklaus

et al. 2014

Front. Hum. Neurosci.

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“…However, when changes in the insomnia scores were contrasted between those with strong antidepressant response to ECT versus those with weaker antidepressant response to ECT, we found that the degree of change in insomnia scores was related to overall change in non-insomnia symptoms, suggesting that improvement in insomnia symptoms is part of the antidepressant effect of ECT. This finding is similar to what has been reported regarding the impact of rTMS and tDCS on insomnia symptoms in MDD, 16;29 suggesting that therapeutic brain stimulation for MDD exerts its effect differently from antidepressant medication.…”

Section: Discussionsupporting

confidence: 90%

“…15 rTMS is associated with reduction in insomnia symptoms, but the improvement in insomnia symptoms is linked with improvement in the overall MDD syndrome, that is, rTMS does not seem to have an anti-insomnia effect apart from its antidepressant effect. 16…”

Section: Introductionmentioning

confidence: 99%

Effects of a Course of Right Unilateral Ultrabrief Pulse Electroconvulsive Therapy Combined With Venlafaxine on Insomnia Symptoms in Elderly Depressed Patients

McCall

Lisanby

Rosenquist

et al. 2018

J. Clin. Psychiatry

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“…Second, the majority of studies were not shamcontrolled, likely explaining the significant placebo effect in some studies (Jiang et al 2019;Arias et al 2010;Zhang et al 2018). Only 5 studies employed sham stimulation in their control groups (Huang et al 2018;Arias et al 2010;Zhang et al 2018;Lin et al 2019;Rosenquist et al 2013).…”

Section: Limitations Of Recent Studiesmentioning

confidence: 99%

Transcranial magnetic stimulation therapeutic applications on sleep and insomnia: a review

Oroz

Kung

Croarkin

et al. 2021

Sleep Science Practice

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Repetitive transcranial magnetic stimulation (rTMS) is a neuromodulatory technique approved by the US Food and Drug Administration for use in treatment-resistant major depressive disorder. It works by generating localized magnetic fields that create depolarizing electrical currents in neurons a few centimeters below the scalp. This localized effect is believed to stimulate neural plasticity, activate compensatory processes, and influence cortical excitability. Additionally, rTMS has been used in a variety of clinical trials for neurological and psychiatric conditions such as anxiety, post-traumatic stress disorder and epilepsy. Beneficial effects in sleep parameters have been documented in these trials, as well as in major depressive disorder, and have led to an interest in using rTMS in the field of sleep medicine for specific disorders such as insomnia, hypersomnia, and restless legs syndrome. It is unknown whether rTMS has intrinsically beneficial properties when applied to primary sleep disorders, or if it only acts on sleep through mood disorders. This narrative review sought to examine available literature regarding the application of rTMS for sleep disorder to identify knowledge gaps and inform future study design. The literature in this area remains scarce, with few randomized clinical trials on rTMS and insomnia. Available studies have found mixed results, with some studies reporting subjective sleep improvement while objective improvement is less consistent. Due to the heterogeneity of results and the variations in rTMS protocols, no definitive conclusions have been reached, signaling the need for further research.

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Left dorsolateral prefrontal transcranial magnetic stimulation (TMS): Sleep factor changes during treatment in patients with pharmacoresistant major depressive disorder

Cited by 29 publications

References 50 publications

The effects of theta-burst stimulation on sleep and vigilance in humans

The effects of theta-burst stimulation on sleep and vigilance in humans

Effects of a Course of Right Unilateral Ultrabrief Pulse Electroconvulsive Therapy Combined With Venlafaxine on Insomnia Symptoms in Elderly Depressed Patients

Transcranial magnetic stimulation therapeutic applications on sleep and insomnia: a review

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